Targeting Myocardial Fibrosis—A Magic Pill in Cardiovascular Medicine?

Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

(2022) Patricia Sansilvestri Morel et al.   PLoS One

Serum Galectin-3 levels and all-cause and cardiovascular mortality in maintenance hemodialysis patients: a prospective cohort study

(2022) Shuxin Liu et al.   BMC Nephrology

Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial

(2021) Gavin A. Lewis et al.   NATURE MEDICINE

IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting αSMA

(2021) Sangmi Ock et al.   Cell Death & Disease

Lcz696 Alleviates Myocardial Fibrosis After Myocardial Infarction Through the sFRP-1/Wnt/β-Catenin Signaling Pathway

(2021) Jing Liu et al.   Frontiers in Pharmacology

Treatment of Hypertensive Heart Disease by Targeting Smad3 Signaling in Mice

(2020) Jinxiu Meng et al.   Molecular Therapy-Methods & Clinical Development

Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

(2020) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis

(2019) Ludwig T. Weckbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cardiac fibrosis: potential therapeutic targets

(2019) Shuin Park et al.   Translational Research

Effects of Sacubitril/Valsartan on Biomarkers of Extracellular Matrix Regulation in Patients With HFrEF

(2019) Michael R. Zile et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac fibrosis – A short review of causes and therapeutic strategies

(2019) Svenja Hinderer et al.   ADVANCED DRUG DELIVERY REVIEWS

Prediction of ventricular arrhythmias in patients with a spontaneous Brugada type 1 pattern: the key is in the electrocardiogram

(2019) Antoine Delinière et al.   EUROPACE

Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart

(2019) Shuaibo Huang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure

(2019) Daniel Pfau et al.   Scientific Reports

Association of Change in N-Terminal Pro–B-Type Natriuretic Peptide Following Initiation of Sacubitril-Valsartan Treatment With Cardiac Structure and Function in Patients With Heart Failure With Reduced Ejection Fraction

(2019) James L. Januzzi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction

(2019) Scott D. Solomon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction

(2019) Adam K. McDiarmid et al.   Journal of the American Heart Association

The reverse remodeling response to sacubitril/valsartan therapy in heart failure with reduced ejection fraction

(2018) Pieter Martens et al.   Cardiovascular Therapeutics

Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism

(2018) Sumia A. Bageghni et al.   FASEB JOURNAL

Data linking diabetes mellitus and atrial fibrillation–how strong is the evidence? From epidemiology and pathophysiology to therapeutic implications

(2018) Răzvan C. Șerban et al.   CANADIAN JOURNAL OF CARDIOLOGY

Cardiac myocyte β3-adrenergic receptors prevent myocardial fibrosis by modulating oxidant stress-dependent paracrine signaling

(2017) Nerea Hermida et al.   EUROPEAN HEART JOURNAL

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Induced Changes in the Fibroblast Secretome, Exosome, and Whole-Cell Proteome Using Cultured, Cardiac-Derived Cells Isolated from Neonatal Mice

(2017) Jake Cosme et al.   JOURNAL OF PROTEOME RESEARCH

High serum N-terminal propeptide of procollagen type III concentration is associated with liver diseases

(2017) Monika Gudowska et al.   Przeglad Gastroenterologiczny

Interleukin-10 Deficiency Impairs Reparative Properties of Bone Marrow-Derived Endothelial Progenitor Cell Exosomes

(2017) Yujia Yue et al.   TISSUE ENGINEERING PART A

Imaging of Myocardial Fibrosis in Patients with End-Stage Renal Disease: Current Limitations and Future Possibilities

(2017) M. P. M. Graham-Brown et al.   Biomed Research International

Phase I Clinical Trial of Autologous Stem Cell–Sheet Transplantation Therapy for Treating Cardiomyopathy

(2017) Shigeru Miyagawa et al.   Journal of the American Heart Association

Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure

(2017) Tong Liu et al.   Frontiers in Physiology

Opposing Actions of Fibroblast and Cardiomyocyte Smad3 Signaling in the Infarcted Myocardium

(2017) Ping Kong et al.   CIRCULATION

Speckle-Tracking Echocardiography

(2017) Sergio Mondillo et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction

(2016) Tomo Yoshizumi et al.   BIOMATERIALS

The Biological Basis for Cardiac Repair After Myocardial Infarction

(2016) Sumanth D. Prabhu et al.   CIRCULATION RESEARCH

Plasma Biomarkers Reflecting Profibrotic Processes in Heart Failure With a Preserved Ejection FractionCLINICAL PERSPECTIVE

(2016) Michael R. Zile et al.   Circulation-Heart Failure

Assessment of myocardial fibrosis with T1 mapping MRI

(2016) R.J. Everett et al.   CLINICAL RADIOLOGY

Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype

(2016) Michael Horckmans et al.   EUROPEAN HEART JOURNAL

A tentative interpretation of the TOPCAT trial based on randomized evidence from the brain natriuretic peptide stratum analysis

(2016) Nicolas Girerd et al.   EUROPEAN JOURNAL OF HEART FAILURE

PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice

(2016) Radiosa Gallini et al.   EXPERIMENTAL CELL RESEARCH

The fibrosis-cell death axis in heart failure

(2016) A. Piek et al.   HEART FAILURE REVIEWS

Effects of 12 weeks of atorvastatin therapy on myocardial fibrosis and circulating fibrosis biomarkers in statin-naïve patients with hypertension with atherosclerosis

(2016) Yi-Yao Chang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Laboratory Monitoring

(2016) Alina Scridon et al.   THERAPEUTIC DRUG MONITORING

Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative PotentialIn Vitro

(2016) Kristin M. French et al.   Stem Cells International

Spontaneous ventricular tachyarrhythmias in β2-adrenoceptor transgenic mice in relation to cardiac interstitial fibrosis

(2015) My-Nhan Nguyen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis

(2015) Guoqi Teng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction

(2015) José González-Santamaría et al.   CARDIOVASCULAR RESEARCH

MiR-125b is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis

(2015) Varun Nagpal et al.   CIRCULATION

Myocardial fibrosis and pro-fibrotic markers in end-stage heart failure patients during continuous-flow left ventricular assist device support

(2015) Sjoukje I. Lok et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Brain-Derived Neurotrophic Factor Regulates TRPC3/6 Channels and Protects Against Myocardial Infarction in Rodents

(2015) Pengzhou Hang et al.   International Journal of Biological Sciences

Circulating Biomarkers of Myocardial Fibrosis

(2015) Begoña López et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Path to an Angiotensin Receptor Antagonist-Neprilysin Inhibitor in the Treatment of Heart Failure

(2015) Eugene Braunwald   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Targeting matrix metalloproteinases in heart disease: Lessons from endogenous inhibitors

(2014) Francis G. Spinale et al.   BIOCHEMICAL PHARMACOLOGY

Micro-RNA 21Targets Dual Specific Phosphatase 8 to Promote Collagen Synthesis in High Glucose–Treated Primary Cardiac Fibroblasts

(2014) Shulei Liu et al.   CANADIAN JOURNAL OF CARDIOLOGY

Enhanced Bioactive Myocardial Transforming Growth Factor-β in Advanced Human Heart Failure

(2014) Shaukat Khan et al.   CIRCULATION JOURNAL

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

IL-1β suppresses TGF-β-mediated myofibroblast differentiation in cardiac fibroblasts

(2014) Hasse Brønnum et al.   GROWTH FACTORS

Direct implantation versus platelet-rich fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute myocardial infarction

(2014) Cheuk-Kwan Sun et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5

(2014) Kristin V.T. Engebretsen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

miR-29b as a Therapeutic Agent for Angiotensin II-induced Cardiac Fibrosis by Targeting TGF-β/Smad3 signaling

(2014) Yang Zhang et al.   MOLECULAR THERAPY

Correction: Connective Tissue Growth Factor Overexpression in Cardiomyocytes Promotes Cardiac Hypertrophy and Protection against Pressure Overload

(2014) Anna N. Panek et al.   PLoS One

Effects of Beta-Blockers on Heart Failure with Preserved Ejection Fraction: A Meta-Analysis

(2014) Feng Liu et al.   PLoS One

Local Hydrogel Release of Recombinant TIMP-3 Attenuates Adverse Left Ventricular Remodeling After Experimental Myocardial Infarction

(2014) S. R. Eckhouse et al.   Science Translational Medicine

In-Hospital Heart Rate Turbulence and Microvolt T-Wave Alternans Abnormalities for Prediction of Early Life-Threatening Ventricular Arrhythmia after Acute Myocardial Infarction

(2013) Mohamed Moussa Arisha et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts

(2013) Sheng Zhao et al.   Journal of Cardiology

Role of miR-145 in cardiac myofibroblast differentiation

(2013) Yao-Sheng Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling

(2013) Chiara Sassoli et al.   PLoS One

Effects of Direct Renin Inhibition on Myocardial Fibrosis and Cardiac Fibroblast Function

(2013) Hui Zhi et al.   PLoS One

Design of the RELAXin in Acute Heart Failure Study

(2012) Piotr Ponikowski et al.   AMERICAN HEART JOURNAL

Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation

(2012) Elena Dolmatova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload

(2012) Catalin F. Baicu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Reduced Endoglin Activity Limits Cardiac Fibrosis and Improves Survival in Heart Failure

(2012) Navin K. Kapur et al.   CIRCULATION

Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy

(2012) Elisa Giannetta et al.   CIRCULATION

Cardiomyocyte Mineralocorticoid Receptors Are Essential for Deoxycorticosterone/Salt-Mediated Inflammation and Cardiac Fibrosis

(2012) Amanda J. Rickard et al.   HYPERTENSION

Induction of Cardiac Fibrosis by β-Blocker in G Protein-independent and G Protein-coupled Receptor Kinase 5/β-Arrestin2-dependent Signaling Pathways

(2012) Michio Nakaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice

(2012) N Chin Lai et al.   LABORATORY INVESTIGATION

The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial

(2012) Scott D Solomon et al.   LANCET

ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy

(2012) Suko Adiarto et al.   LIFE SCIENCES

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

(2012) Karl T. Weber et al.   Nature Reviews Cardiology

Adverse Events of Pirfenidone for the Treatment of Pulmonary Fibrosis: A Meta-Analysis of Randomized Controlled Trials

(2012) Chunguo Jiang et al.   PLoS One

Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-  signaling

(2012) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cells ameliorate cardiac remodeling after myocardial infarction

(2011) Ting-Ting Tang et al.   BASIC RESEARCH IN CARDIOLOGY

Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts

(2011) Li Li et al.   CARDIOVASCULAR RESEARCH

The Development of Myocardial Fibrosis in Transgenic Mice With Targeted Overexpression of Tumor Necrosis Factor Requires Mast Cell–Fibroblast Interactions

(2011) Weili Zhang et al.   CIRCULATION

Long-Term Statin Therapy in Patients With Systolic Heart Failure and Normal Cholesterol: Effects on Elevated Serum Markers of Collagen Turnover, Inflammation, and B-Type Natriuretic Peptide

(2011) Esam Abulhul et al.   CLINICAL THERAPEUTICS

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload

(2011) Norimichi Koitabashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Human Bone Marrow-Derived CD133+ Cells Delivered to a Collagen Patch on Cryoinjured Rat Heart Promote Angiogenesis and Arteriogenesis

(2010) M. Pozzobon et al.   CELL TRANSPLANTATION

Equilibrium Contrast Cardiovascular Magnetic Resonance for the Measurement of Diffuse Myocardial Fibrosis

(2010) Andrew S. Flett et al.   CIRCULATION

Interleukin-17A Is Dispensable for Myocarditis but Essential for the Progression to Dilated Cardiomyopathy

(2010) G. Christian Baldeviano et al.   CIRCULATION RESEARCH

Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts

(2010) Jon-Jon Santiago et al.   DEVELOPMENTAL DYNAMICS

Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias

(2010) Duy T. Nguyen et al.   HEART RHYTHM

Direct Angiotensin II Type 2 Receptor Stimulation Acts Anti-Inflammatory Through Epoxyeicosatrienoic Acid and Inhibition of Nuclear Factor κB

(2010) Franziska Rompe et al.   HYPERTENSION

Why did high-dose rosuvastatin not improve cardiac remodeling in chronic heart failure? Mechanistic insights from the UNIVERSE study

(2010) Emma Ashton et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis

(2010) Pyoung Oh Yoon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy

(2010) Sandra B. Haudek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A Fibrin Patch-Based Enhanced Delivery of Human Embryonic Stem Cell-Derived Vascular Cell Transplantation in a Porcine Model of Postinfarction Left Ventricular Remodeling

(2010) Qiang Xiong et al.   STEM CELLS

Impaired Myocardium Regeneration With Skeletal Cell Sheets—A Preclinical Trial for Tissue-Engineered Regeneration Therapy

(2010) Shigeru Miyagawa et al.   TRANSPLANTATION

IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart

(2009) Indroneal Banerjee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelin-1 and Transforming Growth Factor-β1 Independently Induce Fibroblast Resistance to Apoptosis via AKT Activation

(2009) Priya Kulasekaran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fabrication and Characterization of Prosurvival Growth Factor Releasing, Anisotropic Scaffolds for Enhanced Mesenchymal Stem Cell Survival/Growth and Orientation

(2009) Feng Wang et al.   BIOMACROMOLECULES

Effect of Rosuvastatin on Cardiac Remodeling, Function, and Progression to Heart Failure in Hypertensive Heart With Established Left Ventricular Hypertrophy

(2009) Sung-A Chang et al.   HYPERTENSION

Cardiac mast cells cause atrial fibrillation through PDGF-A–mediated fibrosis in pressure-overloaded mouse hearts

(2009) Chien-hui Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

(2009) Jessie Gu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Role of α1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age

(2008) D. Walter Wray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarction

(2008) Stefan Frantz et al.   BASIC RESEARCH IN CARDIOLOGY

Inhibition of Interleukin-1 by Anakinra Improves Vascular and Left Ventricular Function in Patients With Rheumatoid Arthritis

(2008) Ignatios Ikonomidis et al.   CIRCULATION

miR-133 and miR-30 Regulate Connective Tissue Growth Factor

(2008) Rudy F. Duisters et al.   CIRCULATION RESEARCH

Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating

(2008) A. J. Engler et al.   JOURNAL OF CELL SCIENCE

Association Between Regional Ventricular Function and Myocardial Fibrosis in Hypertrophic Cardiomyopathy Assessed by Speckle Tracking Echocardiography and Delayed Hyperenhancement Magnetic Resonance Imaging

(2008) Zoran B. Popović et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

(2008) E. van Rooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis

(2007) M. Petersen et al.   KIDNEY INTERNATIONAL