Leveraging Substrate Promiscuity of a Radical S-Adenosyl-L-methionine RiPP Maturase toward Intramolecular Peptide Cross-Linking Applications

Promiscuous Installation of d-Amino Acids in Gene-Encoded Peptides

(2021) Madlen Korneli et al.   ACS Synthetic Biology

Trends in peptide drug discovery

(2021) Markus Muttenthaler et al.   NATURE REVIEWS DRUG DISCOVERY

The Epipeptide Biosynthesis Locus epeXEPAB Is Widely Distributed in Firmicutes and Triggers Intrinsic Cell Envelope Stress

(2021) Philipp F. Popp et al.   Microbial Physiology

New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products

(2021) Julia K. Lewis et al.   BIOCHEMISTRY

Selection for constrained peptides that bind to a single target protein

(2021) Andrew M. King et al.   Nature Communications

Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides

(2019) Graham A. Hudson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruminococcin C, an anti-clostridial sactipeptide produced by a prominent member of the human microbiota Ruminococcus gnavus

(2019) Clemence Balty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis

(2019) Kenzie A. Clark et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconstitution and Substrate Specificity of the Thioether-Forming Radical S-Adenosylmethionine Enzyme in Freyrasin Biosynthesis

(2019) Timothy W. Precord et al.   ACS Chemical Biology

Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes

(2019) Hila Sberro et al.   CELL

ANNIVERSARY REVIEW: Octreotide, 40 years later

(2019) Steven W J Lamberts et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

A new antibiotic selectively kills Gram-negative pathogens

(2019) Yu Imai et al.   NATURE

Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase

(2018) Tsehai A. J. Grell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Introduction of D-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-L-Methionine Radical Epimerase

(2018) Anna L. Vagstad et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif

(2018) Leah B. Bushin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical Approach to Enzymatic β-Thioether Bond Formation

(2018) Alessio Caruso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides

(2017) Tyler L. Grove et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products

(2017) Brandon J. Burkhart et al.   ACS Central Science

Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)

(2017) Alhosna Benjdia et al.   Frontiers in Chemistry

Production of Sactipeptides in Escherichia coli: Probing the Substrate Promiscuity of Subtilosin A Biosynthesis

(2016) Paul M. Himes et al.   ACS Chemical Biology

Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-l-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link

(2016) Nathan A. Bruender et al.   BIOCHEMISTRY

Mycofactocin biosynthesis: modification of the peptide MftA by the radical S-adenosylmethionine protein MftC

(2016) Bulat Khaliullin et al.   FEBS LETTERS

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink

(2015) Kelsey R. Schramma et al.   Nature Chemistry

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

SPASM and Twitch Domains inS-Adenosylmethionine (SAM) Radical Enzymes

(2014) Tsehai A. J. Grell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural characterization of thioether-bridged bacteriocins

(2013) Christopher T Lohans et al.   JOURNAL OF ANTIBIOTICS

Pyruvate Formate-lyase and Its Activation by Pyruvate Formate-lyase Activating Enzyme

(2013) Adam V. Crain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two [4Fe-4S] Clusters Containing Radical SAM Enzyme SkfB Catalyze Thioether Bond Formation during the Maturation of the Sporulation Killing Factor

(2013) Leif Flühe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and function of auxiliary iron–sulfur clusters in radical SAM enzymes

(2012) Nicholas D. Lanz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

Biological Systems Discovery In Silico: Radical S-Adenosylmethionine Protein Families and Their Target Peptides for Posttranslational Modification

(2011) D. H. Haft et al.   JOURNAL OF BACTERIOLOGY

Iron-Sulfur (Fe-S) Cluster Assembly

(2010) Silke Wollers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile

(2010) M. C. Rea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrroloquinoline Quinone Biogenesis: Demonstration That PqqE fromKlebsiella pneumoniaeIs a RadicalS-Adenosyl-l-methionine Enzyme

(2009) Stephen R. Wecksler et al.   BIOCHEMISTRY