New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products

Trapping a cross-linked lysine–tryptophan radical in the catalytic cycle of the radical SAM enzyme SuiB

(2021) Aidin R. Balo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis

(2019) Kenzie A. Clark et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconstitution and Substrate Specificity of the Thioether-Forming Radical S-Adenosylmethionine Enzyme in Freyrasin Biosynthesis

(2019) Timothy W. Precord et al.   ACS Chemical Biology

Biosynthesis of the Bis-Prenylated Alkaloids Muscoride A and B

(2019) Antti Mattila et al.   ACS Chemical Biology

The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways

(2019) Rémi Zallot et al.   BIOCHEMISTRY

A Radical Clock Probe Uncouples H-atom Abstraction from Thi-oether Crosslink Formation by the Radical SAM Enzyme SkfB

(2018) Will Kincannon et al.   BIOCHEMISTRY

Mechanistic Investigations of PoyD, a Radical S-Adenosyl-l-methionine Enzyme Catalyzing Iterative and Directional Epimerizations in Polytheonamide A Biosynthesis

(2018) Aubérie Parent et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products

(2018) Kenichi Yokoyama et al.   NATURAL PRODUCT REPORTS

Natural noncanonical protein splicing yields products with diverse β-amino acid residues

(2018) Brandon I. Morinaka et al.   SCIENCE

Vibrational spectra calculation of squamous cell carcinoma in the amide band region

(2018) Daiana R. Bortoletto et al.   VIBRATIONAL SPECTROSCOPY

Radical Approach to Enzymatic β-Thioether Bond Formation

(2018) Alessio Caruso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Post-translational modification of ribosomally synthesized peptides by a radical SAM epimerase in Bacillus subtilis

(2017) Alhosna Benjdia et al.   Nature Chemistry

On the Role of Additional [4Fe-4S] Clusters with a Free Coordination Site in Radical-SAM Enzymes

(2017) Etienne Mulliez et al.   Frontiers in Chemistry

Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-l-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link

(2016) Nathan A. Bruender et al.   BIOCHEMISTRY

Demonstration That the RadicalS-Adenosylmethionine (SAM) Enzyme PqqE Catalyzesde NovoCarbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqD

(2016) Ian Barr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Removal of the 5-nitro-2-pyridine-sulfenyl protecting group from selenocysteine and cysteine by ascorbolysis

(2016) Emma J. Ste. Marie et al.   JOURNAL OF PEPTIDE SCIENCE

FTIR spectroscopy of cysteine as a ready-to-use method for the investigation of plasma-induced chemical modifications of macromolecules

(2016) Friederike Kogelheide et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink

(2015) Kelsey R. Schramma et al.   Nature Chemistry

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

SPASM and Twitch Domains inS-Adenosylmethionine (SAM) Radical Enzymes

(2014) Tsehai A. J. Grell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis

(2014) Kyle L Dunbar et al.   Nature Chemical Biology

Spectroscopic, Steady-State Kinetic, and Mechanistic Characterization of the Radical SAM Enzyme QueE, Which Catalyzes a Complex Cyclization Reaction in the Biosynthesis of 7-Deazapurines

(2012) Reid M. McCarty et al.   BIOCHEMISTRY

Emerging themes in radical SAM chemistry

(2012) Krista A Shisler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A

(2012) Leif Flühe et al.   Nature Chemical Biology

Ab Initio Calculations of Proline Vibrations With and Without Water: Consequences on the Infrared Spectra of Proline-Rich Proteins

(2011) Amélie Banc et al.   APPLIED SPECTROSCOPY

Biological Systems Discovery In Silico: Radical S-Adenosylmethionine Protein Families and Their Target Peptides for Posttranslational Modification

(2011) D. H. Haft et al.   JOURNAL OF BACTERIOLOGY

ENDOR Spectroscopy Shows That Guanine N1 Binds to [4Fe−4S] Cluster II of theS-Adenosylmethionine-Dependent Enzyme MoaA: Mechanistic Implications

(2009) Nicholas S. Lees et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Characterization of AtsB, a Radical SAM Formylglycine-Generating Enzyme That Contains Three [4Fe-4S] Clusters†

(2008) Tyler L. Grove et al.   BIOCHEMISTRY

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY