TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells

Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation

(2021) Helen Carrasco Hope et al.   JCI Insight

Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

(2021) Sarah S. Gabriel et al.   IMMUNITY

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

(2020) Julia M Marchingo et al.   eLife

Targeting the tumor microenvironment and T cell metabolism for effective cancer immunotherapy

(2019) Helen Carrasco Hope et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential Interleukin-2 Transcription Kinetics Render Mouse but Not Human T Cells Vulnerable to Splicing Inhibition Early after Activation

(2019) Debojit Bose et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4+ T cells

(2019) Sarah Dimeloe et al.   Science Signaling

Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism

(2018) Vanessa Zaiatz-Bittencourt et al.   JOURNAL OF IMMUNOLOGY

Single cell analysis of kynurenine and System L amino acid transport in T cells

(2018) Linda V. Sinclair et al.   Nature Communications

Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22

(2017) Rebecca J. Brownlie et al.   Nature Communications

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

(2017) Yeonwoo Park et al.   Cell Reports

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

(2016) Mahima Swamy et al.   NATURE IMMUNOLOGY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity

(2015) Guoliang Cui et al.   CELL

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

(2015) G. C. Preston et al.   EMBO JOURNAL

A Critical Role for Transcription Factor Smad4 in T Cell Function that Is Independent of Transforming Growth Factor β Receptor Signaling

(2015) Ai-Di Gu et al.   IMMUNITY

TCR signaling intensity controls CD8+ T cell responsiveness to TGF- 

(2015) V. Arumugam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

mTOR Links Environmental Signals to T Cell Fate Decisions

(2015) Nicole M. Chapman et al.   Frontiers in Immunology

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Silencing of the TGF-β1 Gene Increases the Immunogenicity of Cells From Human Ovarian Carcinoma

(2012) Huafeng Wei et al.   JOURNAL OF IMMUNOTHERAPY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells

(2009) R. J. Salmond et al.   JOURNAL OF IMMUNOLOGY