Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22

PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection

(2016) Christian J. Maine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

Transforming Growth Factor β-Mediated Suppression of Antitumor T Cells Requires FoxP1 Transcription Factor Expression

(2014) Tom L. Stephen et al.   IMMUNITY

TGF-  Inhibits IL-2 Production and Promotes Cell Cycle Arrest in TCR-Activated Effector/Memory T Cells in the Presence of Sustained TCR Signal Transduction

(2014) L. Das et al.   JOURNAL OF IMMUNOLOGY

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals

(2014) Robert J Salmond et al.   NATURE IMMUNOLOGY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease

(2013) Nunzio Bottini et al.   Annual Review of Immunology

The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells

(2013) J-S Delisle et al.   GENES AND IMMUNITY

Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer

(2013) C. G. Joseph et al.   SCIENCE

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

(2012) Inmoo Rhee et al.   NATURE IMMUNOLOGY

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

(2012) Nu Zhang et al.   NATURE IMMUNOLOGY

Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

(2012) R. J. Brownlie et al.   Science Signaling

Opposing Effects of TGF-β and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T Cells

(2009) Shomyseh Sanjabi et al.   IMMUNITY

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

TGFβ in Cancer

(2008) Joan Massagué   CELL