Identification of histone deacetylase 8 as a novel therapeutic target for renal fibrosis

Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis

(2019) Chongxiang Xiong et al.   FASEB JOURNAL

Cellular Senescence in the Kidney

(2019) Marie-Helena Docherty et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of class I HDACs attenuates renal interstitial fibrosis in a murine model

(2019) Min Yang et al.   PHARMACOLOGICAL RESEARCH

Emerging role of Twist1 in fibrotic diseases

(2018) Xiaoxuan Ning et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HDAC8 inhibition ameliorates pulmonary fibrosis

(2018) Shigeki Saito et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy

(2018) Jing Pan et al.   BIOMEDICINE & PHARMACOTHERAPY

MiR-542-3p controls hepatic stellate cell activation and fibrosis via targeting BMP-7

(2018) Feihong Ji et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Klotho proteins in health and disease

(2018) Makoto Kuro-o   Nature Reviews Nephrology

Epigenetic targeting for acute kidney injury

(2018) Shougang Zhuang   NEPHROLOGY

New insights into the role and mechanism of Wnt/β-catenin signalling in kidney fibrosis

(2018) Yangyang Zuo et al.   NEPHROLOGY

Chronic kidney disease: KDIGO CKD–MBD guideline update: evolution in the face of uncertainty

(2017) Wei Chen et al.   Nature Reviews Nephrology

Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells

(2017) L Das et al.   Oncogenesis

Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice

(2017) Wenjun Lin et al.   Scientific Reports

Epithelial-mesenchymal transition in tissue repair and fibrosis

(2016) Rivka C. Stone et al.   CELL AND TISSUE RESEARCH

Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells

(2016) Sin Y. Choi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Beyond EMT: Epithelial STAT3 as a Central Regulator of Fibrogenesis

(2016) J. S. Duffield   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Stat3 Controls Tubulointerstitial Communication during CKD

(2016) F. Bienaime et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis

(2016) Yanli Yan et al.   KIDNEY INTERNATIONAL

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation

(2016) Agnieszka Loboda et al.   MEDIATORS OF INFLAMMATION

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Partial Epithelial-to-Mesenchymal Transition and Other New Mechanisms of Kidney Fibrosis

(2016) Sara Lovisa et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells

(2015) Jonathan Iaconelli et al.   ACS Chemical Biology

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

HDAC8: a multifaceted target for therapeutic interventions

(2015) Alokta Chakrabarti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Role of bone morphogenetic protein-7 in renal fibrosis

(2015) Rui Xi Li et al.   Frontiers in Physiology

Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance

(2014) Frank J. Kaiser et al.   HUMAN MOLECULAR GENETICS

Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury

(2014) G. Canaud et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Blocking the Class I Histone Deacetylase Ameliorates Renal Fibrosis and Inhibits Renal Fibroblast Activation via Modulating TGF-Beta and EGFR Signaling

(2013) Na Liu et al.   PLoS One

The role of the Janus kinase family/signal transducer and activator of transcription signaling pathway in fibrotic renal disease

(2012) Futoshi Matsui et al.   JOURNAL OF SURGICAL RESEARCH

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Histone Deacetylase 8 Is Required for Centrosome Cohesion and Influenza A Virus Entry

(2011) Yohei Yamauchi et al.   PLoS Pathogens

A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

(2010) Maoyin Pang et al.   KIDNEY INTERNATIONAL

CHD7 cooperates with PBAF to control multipotent neural crest formation

(2010) Ruchi Bajpai et al.   NATURE

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epigenetic Regulation of BMP7 in the Regenerative Response to Ischemia

(2008) T. Marumo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA