HDAC4 promotes nasopharyngeal carcinoma progression and serves as a therapeutic target

TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple

(2020) Runa Zhang et al.   Oncogenesis

Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT

(2020) Hongyang Yi et al.   ONCOGENE

WFDC2 suppresses prostate cancer metastasis by modulating EGFR signaling inactivation

(2020) Yaoyi Xiong et al.   Cell Death & Disease

CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils

(2020) Zheying Mao et al.   Oncogenesis

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

(2018) Charmaine Lang et al.   Cell Stem Cell

Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy

(2018) Yepeng Luan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficacy of tasquinimod in men with metastatic castration-resistant prostate cancer

(2018) Ping Gong et al.   MEDICINE

The Changing Therapeutic Role of Chemo-radiotherapy for Loco-regionally Advanced Nasopharyngeal Carcinoma from Two/Three-Dimensional Radiotherapy to Intensity-Modulated Radiotherapy: A Network Meta-Analysis

(2017) Rui You et al.   Theranostics

Overexpressed HDAC4 is associated with poor survival and promotes tumor progression in esophageal carcinoma

(2016) Li-Si Zeng et al.   Aging-US

Nasopharyngeal carcinoma

(2016) Melvin L K Chua et al.   LANCET

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma

(2016) Nicola Amodio et al.   MOLECULAR CANCER THERAPEUTICS

LncRNA PANDAR regulates the G1/S transition of breast cancer cells by suppressing p16INK4A expression

(2016) Yi Sang et al.   Scientific Reports

Functional role of miR-10b in tamoxifen resistance of ER-positive breast cancer cells through down-regulation of HDAC4

(2015) Aamir Ahmad et al.   BMC CANCER

Down-regulation of prostate stem cell antigen (PSCA) by Slug promotes metastasis in nasopharyngeal carcinoma

(2015) Li Wang et al.   JOURNAL OF PATHOLOGY

Transcriptional repression by the HDAC4–RelB–p52 complex regulates multiple myeloma survival and growth

(2015) Subrahmanya D. Vallabhapurapu et al.   Nature Communications

TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma

(2015) Yi Sang et al.   Oncotarget

PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer

(2014) R. Yao et al.   CANCER RESEARCH

Class IIa HDACs - new insights into their functions in physiology and pathology

(2014) Maribel Parra   FEBS Journal

HDAC4: mechanism of regulation and biological functions

(2014) Zhengke Wang et al.   Epigenomics

Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment

(2012) J. T. Isaacs et al.   CANCER RESEARCH

CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma

(2012) Jian Hong et al.   JOURNAL OF CLINICAL INVESTIGATION

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition

(2011) Min-Zu Wu et al.   MOLECULAR CELL

Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers

(2008) Guoling Ren et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

(2008) Andrew J. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL