Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences

Recent Research Advances in Renin-Angiotensin-Aldosterone System Receptors

(2020) Kengo Azushima et al.   CURRENT HYPERTENSION REPORTS

Angiotensin-converting enzyme 2 influences pancreatic and renal function in diabetic mice

(2020) Heleia Roca-Ho et al.   LABORATORY INVESTIGATION

MiR-200b/c family inhibits renal fibrosis through modulating epithelial-to-mesenchymal transition via targeting fascin-1/CD44 axis

(2020) Hua Fu et al.   LIFE SCIENCES

Evaluation of oxidative stress levels in obesity and diabetes by the free oxygen radical test and free oxygen radical defence assays and correlations with anthropometric and laboratory parameters

(2020) Mihnea-Alexandru Găman et al.   World Journal of Diabetes

MicroRNA-132 attenuated cardiac fibrosis in myocardial infarction-induced heart failure rats

(2020) Guoyu Wang et al.   BIOSCIENCE REPORTS

The Impact of Low Advanced Glycation End Products Diet on Metabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2020) Mohammad Hasan Sohouli et al.   Advances in Nutrition

MicroRNA-34a Promotes Renal Fibrosis by Downregulation of Klotho in Tubular Epithelial Cells

(2019) Yong Liu et al.   MOLECULAR THERAPY

Digital pathology and artificial intelligence

(2019) Muhammad Khalid Khan Niazi et al.   LANCET ONCOLOGY

Deep Learning–Based Histopathologic Assessment of Kidney Tissue

(2019) Meyke Hermsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intrarenal microRNA signature related to the fibrosis process in chronic kidney disease: identification and functional validation of key miRNAs

(2019) Jianwen Yu et al.   BMC Nephrology

Shared and distinct mechanisms of fibrosis

(2019) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

Effects of vitamin D supplementation on advanced glycation end products signaling pathway in T2DM patients: a randomized, placebo-controlled, double blind clinical trial

(2019) Mahsa Omidian et al.   Diabetology & Metabolic Syndrome

Expression of Renin-Angiotensin System Components in the Taste Organ of Mice

(2019) Noriatsu Shigemura et al.   Nutrients

Pathology and natural history of organ fibrosis

(2019) Joaquim Majo et al.   CURRENT OPINION IN PHARMACOLOGY

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling

(2018) Joshua Mayourian et al.   CIRCULATION RESEARCH

miR-21 promotes cardiac fibroblast-to-myofibroblast transformation and myocardial fibrosis by targeting Jagged1

(2018) Xue-liang Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cellular and molecular mechanisms of kidney fibrosis

(2018) Sonja Djudjaj et al.   MOLECULAR ASPECTS OF MEDICINE

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

(2018) Ralf Weiskirchen et al.   MOLECULAR ASPECTS OF MEDICINE

Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

(2018) Aya Mousa et al.   NUTRITION REVIEWS

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

miR-30a attenuates cardiac fibrosis in rats with myocardial infarction by inhibiting CTGF

(2018) Liwen Chen et al.   Experimental and Therapeutic Medicine

miR-133b and miR-199b knockdown attenuate TGF-β1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy

(2018) Zhiqiang Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sex hormones and their influence on chronic kidney disease

(2018) José Manuel Valdivielso et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Vitamin D protects against diabetic nephropathy: Evidence-based effectiveness and mechanism

(2018) Xiaofang Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy

(2018) Maaike Waasdorp et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Diabetes and cardiorenal syndrome: Understanding the “Triple Threat”

(2017) Srikanta Banerjee et al.   Hellenic Journal of Cardiology

MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload–Induced Heart FailureNovelty and Significance

(2017) Robin Verjans et al.   HYPERTENSION

FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction

(2017) Edward R. Smith et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of miR-29b and miR-30c by vitamin D receptor activators contributes to attenuate uraemia-induced cardiac fibrosis

(2017) Sara Panizo et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Treatment combining aliskiren with paricalcitol is effective against progressive renal tubulointerstitial fibrosis via dual blockade of intrarenal renin

(2017) Sungjin Chung et al.   PLoS One

Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2)

(2017) Zheng Xu et al.   Scientific Reports

FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts

(2017) Edward R. Smith et al.   Scientific Reports

Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism

(2017) Ao Li et al.   Scientific Reports

Targeting non-coding RNA for the therapy of renal disease

(2016) Laura Denby et al.   CURRENT OPINION IN PHARMACOLOGY

MicroRNAs in heart failure: from biomarker to target for therapy

(2016) Eline L. Vegter et al.   EUROPEAN JOURNAL OF HEART FAILURE

CD301b+ Macrophages Are Essential for Effective Skin Wound Healing

(2016) Brett Shook et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Silencing of microRNA-132 reduces renal fibrosis by selectively inhibiting myofibroblast proliferation

(2016) Roel Bijkerk et al.   KIDNEY INTERNATIONAL

FGF23 promotes myocardial fibrosis in mice through activation of β-catenin

(2016) Huixin Hao et al.   Oncotarget

A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems

(2016) Jiaxi Xu et al.   Frontiers in Physiology

AGEs-RAGE System Down-Regulates Sirt1 Through the Ubiquitin-Proteasome Pathway to Promote FN and TGF-β1 Expression in Male Rat Glomerular Mesangial Cells

(2015) Kai-Peng Huang et al.   ENDOCRINOLOGY

MicroRNA Let-7i Negatively Regulates Cardiac Inflammation and FibrosisNovelty and Significance

(2015) Xia Wang et al.   HYPERTENSION

Calcitriol ameliorates renal damage in a pre-established proteinuria model

(2015) EDGAR MAQUIGUSSA et al.   Molecular Medicine Reports

Administration of exogenous 1,25(OH)2D3 normalizes overactivation of the central renin-angiotensin system in 1α(OH)ase knockout mice

(2015) Wei Zhang et al.   NEUROSCIENCE LETTERS

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential of vitamin D in treating diabetic cardiomyopathy

(2015) Ting-Wei Lee et al.   NUTRITION RESEARCH

MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4

(2014) Ying Huang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Secreted fibroblast-derived miR-34a induces tubular cell apoptosis in fibrotic kidney

(2014) Yang Zhou et al.   JOURNAL OF CELL SCIENCE

Regulation of Alternative Macrophage Activation by Galectin-3

(2014) A. C. MacKinnon et al.   JOURNAL OF IMMUNOLOGY

Physiology: hemodynamics, endothelial function, renin–angiotensin–aldosterone system, sympathetic nervous system

(2014) L. Gabriel Navar   Journal of the American Society of Hypertension

EGF Receptor Deletion in Podocytes Attenuates Diabetic Nephropathy

(2014) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Advanced Glycation End Products and Diabetic Complications

(2014) Varun Parkash Singh et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities

(2014) Michele Cavalera et al.   Translational Research

Sustained Activation of EGFR Triggers Renal Fibrogenesis after Acute Kidney Injury

(2013) Jinhua Tang et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA29

(2013) Kristin Dawson et al.   CIRCULATION

FGF23 and Klotho in chronic kidney disease

(2013) Hannes Olauson et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Cinacalcet ameliorates cardiac fibrosis in uremic hearts through suppression of endothelial-to-mesenchymal transition

(2013) Min Wu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The regulation and function of micrornas in kidney diseases

(2013) Qingqing Wei et al.   IUBMB LIFE

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS

(2013) Vaibhav B. Patel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Circulating miR-29a, Among Other Up-Regulated MicroRNAs, Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy

(2013) Roberta Roncarati et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Klotho to Treat Kidney Fibrosis

(2013) M. D. Sanchez-Nino et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGF R1

(2013) E. P. Brennan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNA-214 Antagonism Protects against Renal Fibrosis

(2013) L. Denby et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis

(2013) Lei Jiang et al.   KIDNEY INTERNATIONAL

Role of epidermal growth factor receptor in acute and chronic kidney injury

(2013) Jinhua Tang et al.   KIDNEY INTERNATIONAL

The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway

(2013) Rong Li et al.   KIDNEY INTERNATIONAL

Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b

(2013) Bo Wang et al.   KIDNEY INTERNATIONAL

Chronic kidney disease: global dimension and perspectives

(2013) Vivekanand Jha et al.   LANCET

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Vitamin D receptor activation, left ventricular hypertrophy and myocardial fibrosis

(2013) S. Panizo et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Increased Circulating miR-21 Levels Are Associated with Kidney Fibrosis

(2013) François Glowacki et al.   PLoS One

MiR-30-Regulated Autophagy Mediates Angiotensin II-Induced Myocardial Hypertrophy

(2013) Wei Pan et al.   PLoS One

Cardiac Fibroblast-Dependent Extracellular Matrix Accumulation Is Associated with Diastolic Stiffness in Type 2 Diabetes

(2013) Kirk R. Hutchinson et al.   PLoS One

Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease

(2012) Hector Tamez et al.   AMERICAN HEART JOURNAL

Angiotensin-(1–7) attenuates hypertension in exercise-trained renal hypertensive rats

(2012) Amin Shah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Circulating 25-Hydroxy-Vitamin D and Risk of Cardiovascular Disease

(2012) Lu Wang et al.  

Fibroblast growth factor 23 and the heart

(2012) Christian Faul   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Questioning the validity of a recent randomized trial on paricalcitol in patients with echocardiographic evidence of cardiac hypertrophy

(2012) Francesco Fedele et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Vitamin D Therapy and Cardiac Structure and Function in Patients With Chronic Kidney Disease

(2012) Ravi Thadhani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Vitamin D Up-regulates Glucose Transporter 4 (GLUT4) Translocation and Glucose Utilization Mediated by Cystathionine-γ-lyase (CSE) Activation and H2S Formation in 3T3L1 Adipocytes

(2012) Prasenjit Manna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic or Pharmacologic Blockade of EGFR Inhibits Renal Fibrosis

(2012) N. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Arterial stiffness and pulse pressure in CKD and ESRD

(2012) Marie Briet et al.   KIDNEY INTERNATIONAL

COSMOS: the dialysis scenario of CKD–MBD in Europe

(2012) José Luis Fernández-Martín et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury

(2012) Alison J. Kriegel et al.   PHYSIOLOGICAL GENOMICS

Angiotensin II Contributes to Renal Fibrosis Independently of Notch Pathway Activation

(2012) Carolina Lavoz et al.   PLoS One

Crosstalk Between the Renin–Angiotensin System and the Advance Glycation End Product Axis in the Heart: Role of the Cardiac Fibroblast

(2012) Katrina Go Yamazaki et al.   Journal of Cardiovascular Translational Research

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

(2011) Damian Medici et al.   BIOCHEMICAL JOURNAL

Angiotensin II Infusion–Induced Inflammation, Monocytic Fibroblast Precursor Infiltration, and Cardiac Fibrosis are Pressure Dependent

(2011) Guanming Qi et al.   Cardiovascular Toxicology

Regulation of endothelial cell plasticity by TGF-β

(2011) Laurens A. van Meeteren et al.   CELL AND TISSUE RESEARCH

The role of ADAM-mediated shedding in vascular biology

(2011) Daniela Dreymueller et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

FGF23 induces left ventricular hypertrophy

(2011) Christian Faul et al.   JOURNAL OF CLINICAL INVESTIGATION

Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome

(2011) Christian Widera et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphate May Promote CKD Progression and Attenuate Renoprotective Effect of ACE Inhibition

(2011) C. Zoccali et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TGF- /Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29

(2011) W. Qin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

EGFR Signaling Promotes TGF -Dependent Renal Fibrosis

(2011) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNA 802 Stimulates ROMK Channels by Suppressing Caveolin-1

(2011) D.-H. Lin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Suppression of microRNA-29 Expression by TGF- 1 Promotes Collagen Expression and Renal Fibrosis

(2011) B. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis

(2011) X. Zhong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians

(2011) Anand Vaidya et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Scraping fibrosis: Expressway to the core of fibrosis

(2011) Wajahat Z Mehal et al.   NATURE MEDICINE

Chronic Kidney Disease Associated With Environmental Toxins and Exposures

(2010) Peter Soderland et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Role of the Renin-Angiotensin System in Cardiovascular Disease

(2010) Jay N. Cohn   CARDIOVASCULAR DRUGS AND THERAPY

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor- 

(2010) B. Wang et al.   DIABETES

The cardiorenal syndrome in diabetes mellitus

(2010) Hussein H. Karnib et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor

(2010) K. C. Sourris et al.   DIABETOLOGIA

Parathyroid hormone accelerates decompensation following left ventricular hypertrophy

(2010) Hyeseon Cha et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans

(2010) John P. Forman et al.   HYPERTENSION

TGF-β-induced MiR-491-5p Expression Promotes Par-3 Degradation in Rat Proximal Tubular Epithelial Cells

(2010) Qin Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of WNK1 Expression by miR-192 and Aldosterone

(2010) E. Elvira-Matelot et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

miR-192 Mediates TGF- /Smad3-Driven Renal Fibrosis

(2010) A. C. K. Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Parathyroid hormone-potentiated connective tissue growth factor expression in human renal proximal tubular cells through activating the MAPK and NF- B signalling pathways

(2010) Y. Guo et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Controlled Release of Matrix Metalloproteinase-1 Plasmid DNA Prevents Left Ventricular Remodeling in Chronic Myocardial Infarction of Rats

(2009) Xue Lin et al.   CIRCULATION JOURNAL

Blockage of receptor for advanced glycation end products prevents development of cardiac dysfunction in db/db type 2 diabetic mice

(2009) Jan M. Nielsen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure

(2008) Vijay Divakaran et al.   CIRCULATION RESEARCH

miR-133 and miR-30 Regulate Connective Tissue Growth Factor

(2008) Rudy F. Duisters et al.   CIRCULATION RESEARCH

Cardiac Overexpression of Angiotensin Converting Enzyme 2 Protects the Heart From Ischemia-Induced Pathophysiology

(2008) Shant Der Sarkissian et al.   HYPERTENSION

Candesartan Ameliorates Cardiac Dysfunction Observed in Angiotensin-Converting Enzyme 2-Deficient Mice

(2008) Kazuto Nakamura et al.   HYPERTENSION RESEARCH

Paricalcitol Inhibits Renal Inflammation by Promoting Vitamin D Receptor-Mediated Sequestration of NF- B Signaling

(2008) X. Tan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Suppression of renin–angiotensin gene expression in the kidney by paricalcitol

(2008) Michael Freundlich et al.   KIDNEY INTERNATIONAL

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY