SIRT6 protects against palmitate-induced pancreatic β-cell dysfunction and apoptosis

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy

(2016) Jing Lu et al.   Translational Research

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage

(2016) Jiaxiang Shao et al.   Protein & Cell

Islet β-cell failure in type 2 diabetes – Within the network of toxic lipids

(2015) Justyna Janikiewicz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

(2015) Xiwen Xiong et al.   DIABETOLOGIA

The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells

(2015) Moran Choe et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Minireview: Autophagy in Pancreatic β-Cells and Its Implication in Diabetes

(2015) Hirotaka Watada et al.   MOLECULAR ENDOCRINOLOGY

Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?

(2014) Rohit B. Sharma et al.   Current Diabetes Reports

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of islet β cell autophagy in the pathogenesis of diabetes

(2014) Myung-Shik Lee   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence

(2013) N. Takasaka et al.   JOURNAL OF IMMUNOLOGY

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

(2011) Eriko Michishita et al.   CELL CYCLE

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

(2011) Bo Yang et al.   CELL CYCLE

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

(2010) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

The Emerging Genetic Architecture of Type 2 Diabetes

(2008) Alessandro Doria et al.   Cell Metabolism

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY