Positive and negative effects of cellular senescence during female reproductive aging and pregnancy

Placental membrane aging and HMGB1 signaling associated with human parturition

(2016) Ramkumar Menon et al.   Aging-US

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Differential senescence in feto-maternal tissues during mouse pregnancy

(2016) Elizabeth A. Bonney et al.   PLACENTA

Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells

(2016) Yan Meng et al.   Reproductive Sciences

Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise

(2016) Reza Soleimani et al.   Aging-US

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

(2016) Michael C. Velarde et al.   Aging-US

Progesterone inhibits in vitro fetal membrane weakening

(2015) Deepak Kumar et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Chorioamniotic membrane senescence: a signal for parturition?

(2015) Faranak Behnia et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The developmental origins of the mammalian ovarian reserve

(2015) Kathryn J. Grive et al.   DEVELOPMENT

NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization

(2015) Yixin Liao et al.   HUMAN REPRODUCTION

The Kruppel-like factors in female reproductive system pathologies

(2015) R. C. M. Simmen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes

(2015) Eryn H. Dutta et al.   MOLECULAR HUMAN REPRODUCTION

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells

(2015) Hua Zhang et al.   NATURE MEDICINE

Aging of intrauterine tissues in spontaneous preterm birth and preterm premature rupture of the membranes: A systematic review of the literature

(2015) J. Polettini et al.   PLACENTA

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells

(2015) Michael C. Velarde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats

(2015) Vijayakumar Govindaraj et al.   Systems Biology in Reproductive Medicine

DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

(2015) Josie K. Collins et al.   Nature Communications

Simvastatin suppresses breast cancer cell proliferation induced by senescent cells

(2015) Su Liu et al.   Scientific Reports

Telomere Fragment Induced Amnion Cell Senescence: A Contributor to Parturition?

(2015) Jossimara Polettini et al.   PLoS One

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma

(2015) Ryan T Pitman et al.   Oncotarget

Histological Evidence of Oxidative Stress and Premature Senescence in Preterm Premature Rupture of the Human Fetal Membranes Recapitulated in Vitro

(2014) Ramkumar Menon et al.   AMERICAN JOURNAL OF PATHOLOGY

Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes

(2014) Ramkumar Menon et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Different fates of oocytes with DNA double-strand breaksin vitroandin vivo

(2014) Fei Lin et al.   CELL CYCLE

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides

(2013) Neelu Puri et al.   CANCER LETTERS

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

The Role of Exchange Protein Directly Activated by Cyclic AMP 2-mediated Calreticulin Expression in the Decidualization of Human Endometrial Stromal Cells

(2013) Kazuya Kusama et al.   ENDOCRINOLOGY

Cell fusion induced by ERVWE1 or measles virus causes cellular senescence

(2013) A. Chuprin et al.   GENES & DEVELOPMENT

Evaluation of telomere length in cumulus cells as a potential biomarker of oocyte and embryo quality

(2013) E.-H. Cheng et al.   HUMAN REPRODUCTION

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

The menopause and aging, a comparative perspective

(2013) Caleb E. Finch   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Meiotic recombination in mammals: localization and regulation

(2013) Frédéric Baudat et al.   NATURE REVIEWS GENETICS

Age-Associated Metabolic and Morphologic Changes in Mitochondria of Individual Mouse and Hamster Oocytes

(2013) Fatma Simsek-Duran et al.   PLoS One

Senescence of Primary Amniotic Cells via Oxidative DNA Damage

(2013) Ramkumar Menon et al.   PLoS One

Central Role of Cellular Senescence in TSLP-Induced Airway Remodeling in Asthma

(2013) Jinxiang Wu et al.   PLoS One

Proteomic Biomarkers for Spontaneous Preterm Birth

(2013) Marian Kacerovsky et al.   Reproductive Sciences

Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans

(2013) S. Titus et al.   Science Translational Medicine

Uterine Deletion ofTrp53Compromises Antioxidant Responses in the Mouse Decidua

(2012) Kristin E. Burnum et al.   ENDOCRINOLOGY

Follicular Growth and Atresia in Mammalian Ovaries: Regulation by Survival and Death of Granulosa Cells

(2012) Fuko MATSUDA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women

(2012) Yvonne A R White et al.   NATURE MEDICINE

Short Fetal Leukocyte Telomere Length and Preterm Prelabor Rupture of the Membranes

(2012) Ramkumar Menon et al.   PLoS One

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Inhibition of Doxorubicin-Induced Senescence by PPARδ Activation Agonists in Cardiac Muscle Cells: Cooperation between PPARδ and Bcl6

(2012) Paola Altieri et al.   PLoS One

Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling

(2012) S. Rajagopalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Preterm Placental Calcification in High-Risk Pregnancy as a Predictor of Poor Uteroplacental Blood Flow and Adverse Pregnancy Outcome

(2012) Kuo-Hu Chen et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Pregnancy after Age 50: Defining Risks for Mother and Child

(2011) Daniel Kort et al.   AMERICAN JOURNAL OF PERINATOLOGY

The association of maternal age with placental weight: a population-based study of 536 954 pregnancies

(2011) C Haavaldsen et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Pulmonary Artery Smooth Muscle Cell Senescence Is a Pathogenic Mechanism for Pulmonary Hypertension in Chronic Lung Disease

(2011) Hibo Noureddine et al.   CIRCULATION RESEARCH

Mother's body size and placental size predict coronary heart disease in men

(2011) J. G. Eriksson et al.   EUROPEAN HEART JOURNAL

Mechanism of T-oligo-induced cell cycle arrest in Mia-Paca pancreatic cancer cells

(2011) Andrew M. Rankin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis

(2011) Vicki Flenady et al.   LANCET

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Amniotic Fluid Eicosanoids in Preterm and Term Births: Effects of Risk Factors for Spontaneous Preterm Labor

(2011) Ramkumar Menon et al.   OBSTETRICS AND GYNECOLOGY

T-Oligos Inhibit Growth and Induce Apoptosis in Human Ovarian Cancer Cells

(2011) Sibaji Sarkar et al.   OLIGONUCLEOTIDES

Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice

(2011) Y. Hirota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomarkers of Spontaneous Preterm Birth: An Overview of The Literature in the Last Four Decades

(2011) Ramkumar Menon et al.   Reproductive Sciences

Amnion-Derived Mesenchymal Stromal Cells Show Angiogenic Properties but Resist Differentiation into Mature Endothelial Cells

(2011) Julia König et al.   STEM CELLS AND DEVELOPMENT

Cosmetic outcomes of various skin closure methods following cesarean delivery: a randomized trial

(2010) Antonella Cromi et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Longitudinal Change in Reproductive Hormones and Depressive Symptoms Across the Menopausal Transition

(2010) Joyce T. Bromberger et al.   ARCHIVES OF GENERAL PSYCHIATRY

Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice

(2010) Yasushi Hirota et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Ovarian Reserve from Conception to the Menopause

(2010) W. Hamish B. Wallace et al.   PLoS One

Exploring the relationship between preterm placental calcification and adverse maternal and fetal outcome

(2010) K. H. Chen et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Osteopathic manipulative treatment of back pain and related symptoms during pregnancy: a randomized controlled trial

(2009) John C. Licciardone et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2

(2009) Paolo Spallarossa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

New Insights into the Role of Androgens in Wolffian Duct Stabilization in Male and Female Rodents

(2009) Michelle Welsh et al.   ENDOCRINOLOGY

Cellular senescence in usual type uterine leiomyoma

(2009) Jordan Laser et al.   FERTILITY AND STERILITY

Correlation of Telomere Length and Telomerase Activity with Occult Ovarian Insufficiency

(2009) Samantha Butts et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fetal Growth Restriction is Associated with Accelerated Telomere Shortening and Increased Expression of Cell Senescence Markers in the Placenta

(2009) P. Davy et al.   PLACENTA

Decreased adherence and spontaneous separation of fetal membrane layers – amnion and choriodecidua – a possible part of the normal weakening process

(2009) A. Strohl et al.   PLACENTA

Antioxidant Enzyme Expression, Lipid Peroxidation, and Protein Oxidation in Human Myometrium With Parturition

(2009) Raheela N. Khan et al.   Reproductive Sciences

Maternal age and risk of stillbirth: a systematic review

(2008) L. Huang et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Corticotrophin-Releasing Hormone in Lipopolysaccharide-Stimulated Term Fetal Membranes and Amniotic Fluid From Term and Preterm Birth in African Americans and Caucasians

(2008) Ramkumar Menon et al.   Reproductive Sciences

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

The Effect of Delaying Childbirth on Primary Cesarean Section Rates

(2008) Gordon C. S Smith et al.   PLOS MEDICINE

Bone Mineral Density Changes during the Menopause Transition in a Multiethnic Cohort of Women

(2007) Joel S. Finkelstein et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM