Article
Cell Biology
Ting-Yu Chen, Tzu-Chien Lin, Pao-Lin Kuo, Zi-Rong Chen, Hui-ling Cheng, Yu-Ying Chao, Jhih-Siang Syu, Fu- Lu, Chia-Yih Wang
Summary: SEPT7 plays a crucial role in maintaining proper cell proliferation and microtubule array formation by interacting with p150(glued) at the centrosome. Depletion of SEPT7 leads to mitotic defects, disorganized microtubule nucleation, and reduced cell migration, while overexpression of p150(glued) rescues the defective phenotypes. These findings highlight the importance of SEPT7 in regulating cell division and organization.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Mira Kuzmic, Gerard Castro Linares, Jindriska Leischner Fialova, Francois Iv, Daniele Salaun, Alex Llewellyn, Maxime Gomes, Mayssa Belhabib, Yuxiang Liu, Keisuke Asano, Magda Rodrigues, Daniel Isnardon, Taro Tachibana, Gijsje H. Koenderink, Ali Badache, Manos Mavrakis, Pascal Verdier-Pinard
Summary: This study identified the key molecular determinants and potential regulatory roles of septin-microtubule interaction, providing new insights into the mechanisms underlying septin-associated pathologies.
JOURNAL OF CELL SCIENCE
(2022)
Article
Biology
Maria-Bernadette Madel, Julia Halper, Lidia Ibanez, Lozano Claire, Matthieu Rouleau, Antoine Boutin, Adrien Mahler, Rodolphe Pontier-Bres, Thomas Ciucci, Majlinda Topi, Christophe Hue, Jerome Amiaud, Salvador Iborra, David Sancho, Dominique Heymann, Henri-Jean Garchon, Dorota Czerucka, Florence Apparailly, Isabelle Duroux-Richard, Abdelilah Wakkach, Claudine Blin-Wakkach
Summary: This study explores the specific traits of inflammatory and steady-state osteoclasts using transcriptomic profiling, differentiation assays, and in vivo analysis in mice. The authors identify and validate pattern-recognition receptors (PRR) Tlr2, Dectin-1, and Mincle as major regulators of inflammatory osteoclasts. They demonstrate that the administration of the yeast probiotic Saccharomyces boulardii CNCM I-745 (Sb) reduces bone loss in ovariectomized mice by regulating the inflammatory environment and inhibiting inflammatory osteoclastogenesis. The study also shows that Sb derivatives and agonists of Tlr2, Dectin-1, and Mincle specifically inhibit the differentiation of inflammatory osteoclasts in vitro. These findings have important implications for the development of therapeutic strategies for inflammatory bone loss.
Article
Cell Biology
Lingye Zhang, Anni Zhou, Shengtao Zhu, Li Min, Si Liu, Peng Li, Shutian Zhang
Summary: This review summarizes the biological functions and molecular mechanisms of ARHGAP26 in different tumors, proposes the potential clinical value of ARHGAP26 in cancer treatment, and discusses current issues that need to be addressed.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Diego A. Leonardo, Italo A. Cavini, Fernanda A. Sala, Deborah C. Mendonca, Higor V. D. Rosa, Patricia S. Kumagai, Edson Crusca Jr, Napoleao F. Valadares, Ivo A. Marques, Jose Brandao-Neto, Claudia E. Munte, Hans R. Kalbitzer, Nicolas Soler, Isabel Uson, Ingemar Andre, Ana P. U. Araujo, Humberto D'Muniz Pereira, Richard C. Garratt
Summary: Septins are composed of different paralogues that must be correctly assembled into functional filaments important for essential cellular events. Most septins possess C-terminal domains capable of forming coils, and the study reveals dimeric structures with both parallel and antiparallel arrangements. Both arrangements are energetically accessible, with antiparallel structures presenting a mixed coiled-coil interface.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Beatrice Benoit, Anita Baillet, Christian Pous
Summary: This review extensively covers the complex relationships between JNK and cytoskeleton elements, including mechanisms controlling JNK activation, known substrates, and the specific locations of upstream regulators. It also provides techniques and tools for further research on the interplay between different types of cytoskeleton filaments mediated by JNK.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Kathryn M. Appleton, Charuta C. Palsuledesai, Sean A. Misek, Maja Blake, Joseph Zagorski, Kathleen A. Gallo, Thomas S. Dexheimer, Richard R. Neubig
Summary: In NRAS mutant melanoma cells, activation of the Rho pathway is associated with high intrinsic resistance to the MEK inhibitor trametinib. Combining a Rho/MRTF pathway inhibitor with trametinib can synergistically reduce cell viability and induce apoptosis in resistant melanoma cells. Targeting both the Rho/MRTF pathway and MEK shows therapeutic potential in NRAS mutant melanomas.
Review
Cardiac & Cardiovascular Systems
Mengqi Li, Qingzheng Jiao, Wenqiang Xin, Shulin Niu, Mingming Liu, Yanxin Song, Zengguang Wang, Xinyu Yang, Degang Liang
Summary: Atherosclerosis is a major cause of cardiovascular disease, but its mechanism is not fully understood. Rho GEFs play a crucial role in atherosclerosis, but there is limited research on this topic. Studies have revealed the mechanisms of how Rho GEFs regulate atherosclerosis through experiments.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Laura Lucia Trebucq, Georgina Alexandra Cardama, Pablo Lorenzano Menna, Diego Andres Golombek, Juan Jose Chiesa, Luciano Marpegan
Summary: The study revealed circadian modulation in the efficacy of 1A-116, likely through RAC1 pathway rhythmicity, suggesting that a chronopharmacological approach is a feasible strategy to improve glioblastoma treatment.
Article
Cell Biology
Han-Yu Wang, Chun-Hsiang Lin, Yi-Ru Shen, Ting-Yu Chen, Chia-Yih Wang, Pao-Lin Kuo
Summary: The study reveals that PKA phosphorylates SEPT7, disrupting septin filament dynamics and ciliogenesis, leading to a novel understanding of the biological function of SEPT7 phosphorylation in cell growth and migration.
Article
Cell Biology
Darya Safavian, Moshe S. S. Kim, Hong Xie, Maha El-Zeiry, Oliva Palander, Lu Dai, Richard F. F. Collins, Carol Froese, Rachel Shannon, Koh-Ichi Nagata, William S. S. Trimble
Summary: Safavian et al. demonstrate that septins and ARHGEF18 regulate primary ciliogenesis by activating RhoA, exocyst complex, and recruiting transition zone components. SEPTIN9 regulates RhoA signaling at the base of cilia by activating ARHGEF18. Upregulating RhoA signaling at the cilium can rescue ciliary defects caused by SEPTIN9 depletion.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Lichan Yuan, Na Zhao, Junyi Wang, Yuying Liu, Li Meng, Shuyu Guo, Erik A. C. Wiemer, Qi Chen, Yelin Mao, Jingjing Ben, Junqing Ma
Summary: The study revealed that MVP acts as a negative regulator of osteoclastogenesis, inhibiting bone resorption and potentially serving as a therapeutic target for preventing bone loss.
Review
Biochemistry & Molecular Biology
Kana Asano-Matsuda, Sajida Ibrahim, Tomoko Takano, Jun Matsuda
Summary: The initial step of urine formation involves selective filtration of plasma in the glomerulus, where a filtration barrier made up of three layers (fenestrated endothelial cells, glomerular basement membrane, and podocytes) retains blood cells and large proteins while removing waste products. Rho GTPases serve as crucial molecular switches in regulating podocyte health and barrier function, with particular focus on subcellular compartments where signaling events occur.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander K. Salomon, Sai Aung Phyo, Naima Okami, Julie Heffler, Patrick Robison, Alexey I. Bogush, Benjamin L. Prosser
Summary: In heart failure, a post-translationally detyrosinated microtubule increase in abundance, leading to stiffening of the cardiomyocyte and impairment of its contractile function. This process promotes interactions between microtubules, desmin intermediate filaments, and the sarcomere, increasing cytoskeletal stiffness. Through experiments, it was found that desmin stabilizes growing microtubules at the sarcomere Z-disk level and rescues shrinking microtubules from depolymerization. Lowering detyrosination levels results in frequent depolymerization and less efficient growth of microtubules.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Review
Cell Biology
Anne Blangy
BIOLOGY OF THE CELL
(2017)
Article
Multidisciplinary Sciences
Yann Ferrandez, Wenhua Zhang, Francois Peurois, Lurlene Akendengue, Anne Blangy, Mahel Zeghouf, Jacqueline Cherfils
SCIENTIFIC REPORTS
(2017)
Article
Biology
Juliette van Dijk, Guillaume Bompard, Julien Cau, Shinji Kunishima, Gabriel Rabeharivelo, Julio Mateos-Langerak, Chantal Cazevieille, Patricia Cavelier, Brigitte Boizet-Bonhoure, Claude Delsert, Nathalie Morin
Article
Cell Biology
Justine Maurin, Anne Morel, Cedric Hassen-Khodja, Virginie Vives, Pierre Jurdic, Irma Machuca-Gayet, Anne Blangy
EUROPEAN JOURNAL OF CELL BIOLOGY
(2018)
Article
Cell Biology
Guillaume Bompard, Juliette van Dijk, Julien Cau, Yoann Lannay, Guillaume Marcellin, Aleksandra Lawera, Siem van der Laan, Krzysztof Rogowski
Article
Cell Biology
Chaker Slaymi, Emmanuel Vignal, Gaelle Cres, Pierre Roux, Anne Blangy, Peggy Raynaud, Philippe Fort
BIOLOGY OF THE CELL
(2019)
Article
Cell Biology
Sarah Guimbal, Anne Morel, David Guerit, Manon Chardon, Anne Blangy, Virginie Vives
BIOLOGY OF THE CELL
(2019)
Article
Cell Biology
Siem van der Laan, Maude F. Leveque, Guillaume Marcellin, Lubomir Vezenkov, Yoann Lannay, Geronimo Dubra, Guillaume Bompard, Sara Ovejero, Serge Urbach, Andrew Burgess, Muriel Amblard, Yvon Sterkers, Patrick Bastien, Krzysztof Rogowski
Article
Cell Biology
Olga Gubar, Pauline Croise, Sergii Kropyvko, Tetyana Gryaznova, Petra Toth, Anne Blangy, Nicolas Vitale, Alla Rynditch, Stephane Gasman, Stephane Ory
JOURNAL OF CELL SCIENCE
(2020)
Article
Cell Biology
Justine Maurin, Anne Blangy, Guillaume Bompard
EUROPEAN JOURNAL OF CELL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Juliette van Dijk, Guillaume Bompard, Gabriel Rabeharivelo, Julien Cau, Claude Delsert, Nathalie Morin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Justine Maurin, Anne Morel, David Guerit, Julien Cau, Serge Urbach, Anne Blangy, Guillaume Bompard
Summary: Osteoclasts are crucial for bone health, with TUBB6 playing a key role in organizing the cytoskeleton. TUBB6 not only controls microtubule and actin dynamics in osteoclasts, but also regulates other proteins like ARHGAP10, affecting cell activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Lucile Mounier, Anne Morel, Yann Ferrandez, Jukka Morko, Jukka Vaaraniemi, Marine Gilardone, Didier Roche, Jacqueline Cherfils, Anne Blangy
JOURNAL OF MEDICINAL CHEMISTRY
(2020)