Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder

MeCP2: The Genetic Driver of Rett Syndrome Epigenetics

(2021) Katrina V. Good et al.   Frontiers in Genetics

Zebrafish as an animal model for biomedical research

(2021) Tae-Young Choi et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The zebrafish issue: 25 years on

(2021) Mary C. Mullins et al.   DEVELOPMENT

Novel pre-clinical model for CDKL5 Deficiency Disorder

(2021) Rita J. Serrano et al.   Disease Models & Mechanisms

The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update

(2021) Xinyi Wang et al.   Frontiers in Pharmacology

CDKL5 Deficiency Disorder—A Complex Epileptic Encephalopathy

(2020) Martyna Jakimiec et al.   Brain Sciences

Zebrafish Models of Craniofacial Malformations: Interactions of Environmental Factors

(2020) S. T. Raterman et al.   Frontiers in Cell and Developmental Biology

Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

(2019) Magdalena Miranda et al.   Frontiers in Cellular Neuroscience

The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

(2018) Barbara D. Fontana et al.   EXPERIMENTAL NEUROLOGY

Neuropathological profile of the pentylenetetrazol (PTZ) kindling model

(2018) E. Samokhina et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women

(2018) David Cheishvili et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome

(2018) Marta Vitorino et al.   MOLECULAR BIOLOGY REPORTS

Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory

(2018) Kosuke Okuda et al.   PLoS One

Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder

(2018) Claudia Fuchs et al.   NEURAL PLASTICITY

Molecular and Synaptic Bases of CDKL5 Disorder

(2018) Yong-Chuan Zhu et al.   Developmental Neurobiology

Zebrafish Models of Neurodevelopmental Disorders: Past, Present, and Future

(2018) Catalina Sakai et al.   Frontiers in Molecular Neuroscience

Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors

(2017) Cian-Ling Jhang et al.   HUMAN MOLECULAR GENETICS

Zebrafish as a Model for Epilepsy-Induced Cognitive Dysfunction: A Pharmacological, Biochemical and Behavioral Approach

(2017) Uday P. Kundap et al.   Frontiers in Pharmacology

Expression analyses of splice variants of zebrafish cyclin-dependent kinase-like 5 and its substrate, amphiphysin 1

(2016) Syouichi Katayama et al.   GENE

CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization

(2016) Mohammad Sarfaraz Nawaz et al.   PLoS One

A Hybrid Electrical/Chemical Circuit in the Spinal Cord Generates a Transient Embryonic Motor Behavior

(2014) L. D. Knogler et al.   JOURNAL OF NEUROSCIENCE

Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder

(2014) Elena Amendola et al.   PLoS One

Identification of amphiphysin 1 as an endogenous substrate for CDKL5, a protein kinase associated with X-linked neurodevelopmental disorder

(2013) Mari Sekiguchi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MeCP2-mediated alterations of striatal features accompany psychomotor deficits in a mouse model of Rett syndrome

(2013) Fang-Chi Kao et al.   Brain Structure & Function

Recurrent mutations in theCDKL5gene: Genotype-phenotype relationships

(2012) Nadia Bahi-Buisson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The CDKL5 disorder is an independent clinical entity associated with early-onset encephalopathy

(2012) Stephanie Fehr et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

(2012) I.-T. J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The developing zebrafish (Danio rerio): A vertebrate model for high-throughput screening of chemical libraries

(2011) Charles A. Lessman   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Zebrafish embryos and larvae: A new generation of disease models and drug screens

(2011) Shaukat Ali et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression

(2010) Markus Zweier et al.   HUMAN MUTATION

CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling

(2010) Q. Chen et al.   JOURNAL OF NEUROSCIENCE

Novel mutations in the CDKL5 gene, predicted effects and associated phenotypes

(2009) S. Russo et al.   NEUROGENETICS

Key clinical features to identify girls with CDKL5 mutations

(2008) Nadia Bahi-Buisson et al.   BRAIN

CDKL5 Expression Is Modulated during Neuronal Development and Its Subcellular Distribution Is Tightly Regulated by the C-terminal Tail

(2008) Laura Rusconi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY