The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update

Hesperidin Interacts With CREB-BDNF Signaling Pathway to Suppress Pentylenetetrazole-Induced Convulsions in Zebrafish

(2021) Pallavi Sharma et al.   Frontiers in Pharmacology

Kinetics of serum brain-derived neurotrophic factor (BDNF) concentration levels in epileptic patients after generalized tonic-clonic seizures

(2021) Łukasz A. Poniatowski et al.   EPILEPSY RESEARCH

Estrogen administration attenuates post‑stroke depression by enhancing CREB/BDNF/TrkB signaling in the rat hippocampus

(2021) Huigang Jiang et al.   Experimental and Therapeutic Medicine

Subicular Caspase‐1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy

(2021) Cenglin Xu et al.   ANNALS OF NEUROLOGY

The interplay of seizures-induced axonal sprouting and transcription-dependent Bdnf repositioning in the model of temporal lobe epilepsy

(2021) Anna Skupien-Jaroszek et al.   PLoS One

The role of REST/NRSF, TrkB and BDNF in neurobiological mechanisms of different susceptibility to seizure in a PTZ model of epilepsy

(2020) Natalia Chmielewska et al.   BRAIN RESEARCH BULLETIN

A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy

(2020) Bin Chen et al.   Nature Communications

Exercise, redox system and neurodegenerative diseases

(2020) Helong Quan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Brain-derived neurotrophic factor and mental disorders

(2020) Chin-Chuen Lin et al.   Biomedical Journal

Pharmaco‐genetic inhibition of pyramidal neurons retards hippocampal kindling‐induced epileptogenesis

(2020) Li‐Ying Chen et al.   CNS Neuroscience & Therapeutics

Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy

(2020) Sara Fernández-García et al.   Cell Death & Disease

The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line

(2020) Ahmet Sevki Taskiran et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy

(2020) Nan Yang et al.   Oxidative Medicine and Cellular Longevity

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy

(2019) Christine Doherty et al.   EPILEPSY & BEHAVIOR

FTY720 Improves Behavior, Increases Brain Derived Neurotrophic Factor and Reduces α-Synuclein Pathology in Parkinsonian GM2 +/− Mice

(2019) Guadalupe Vidal-Martinez et al.   NEUROSCIENCE

An update for epilepsy research and antiepileptic drug development: Toward precise circuit therapy

(2019) Yi Wang et al.   PHARMACOLOGY & THERAPEUTICS

Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy

(2019) Cenglin Xu et al.   ANNALS OF NEUROLOGY

Progesterone modulates post-traumatic epileptogenesis through regulation of BDNF-TrkB signaling and cell survival-related pathways in the rat hippocampus

(2019) Tahereh Ghadiri et al.   NEUROSCIENCE LETTERS

Targeting BDNF/TrkB pathways for preventing or suppressing epilepsy

(2019) Thiri W. Lin et al.   NEUROPHARMACOLOGY

Prophylactic effect of physical exercise on Aβ1–40-induced depressive-like behavior: Role of BDNF, mTOR signaling, cell proliferation and survival in the hippocampus

(2019) Julia M. Rosa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neuro-regeneration Therapeutic for Alzheimer’s Dementia: Perspectives on Neurotrophic Activity

(2019) Miao-Kun Sun et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Adult neurogenesis in epileptogenesis: An update for preclinical finding and potential clinical translation

(2019) Liying Chen et al.   Current Neuropharmacology

Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling

(2019) Kuan-Ming Chiu et al.   NEUROCHEMISTRY INTERNATIONAL

Brain-derived neurotrophic factor and epilepsy: a systematic review

(2018) Lorenzo Iughetti et al.   NEUROPEPTIDES

Increased Expression of Brain-Derived Neurotrophic Factor Transcripts I and VI, cAMP Response Element Binding, and Glucocorticoid Receptor in the Cortex of Patients with Temporal Lobe Epilepsy

(2017) G. A. Martínez-Levy et al.   MOLECULAR NEUROBIOLOGY

The role of BDNF in Alzheimer's disease

(2017) Heikki Tanila   NEUROBIOLOGY OF DISEASE

Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy

(2017) Yi Wang et al.   NEURON

Long-term memory deficits in temporal lobe epilepsy

(2017) E. Tramoni-Negre et al.   REVUE NEUROLOGIQUE

Interictal serum brain-derived neurotrophic factor level reflects white matter integrity, epilepsy severity, and cognitive dysfunction in chronic temporal lobe epilepsy

(2016) Nai-Ching Chen et al.   EPILEPSY & BEHAVIOR

The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity

(2016) Wei Wang et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats

(2016) Handan Soysal et al.   NEUROPEPTIDES

Role of BDNF Val66Met functional polymorphism in temporal lobe epilepsy

(2015) Ning Shen et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons

(2015) J. Gibon et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Rapid Local RhoA Synthesis Is Required for Hippocampal Synaptic Plasticity

(2015) V. Briz et al.   JOURNAL OF NEUROSCIENCE

Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study

(2015) Hidayati Mohd Sha’ari et al.   MOLECULAR NEUROBIOLOGY

Effect of actual long-term spaceflight on BDNF, TrkB, p75, BAX and BCL-XL genes expression in mouse brain regions

(2015) V.S. Naumenko et al.   NEUROSCIENCE

Antiseizure effects of TrkB kinase inhibition

(2014) Gumei Liu et al.   EPILEPSIA

ILAE Official Report: A practical clinical definition of epilepsy

(2014) Robert S. Fisher et al.   EPILEPSIA

Acute administration of the small-molecule p75NTRligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus

(2014) H.L. Grabenstatter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effects of olive leaf polyphenols on male mouse brain NGF, BDNF and their receptors TrkA, TrkB and p75

(2014) Valentina Carito et al.   NATURAL PRODUCT RESEARCH

Novel Higher-Order Epigenetic Regulation of the Bdnf Gene upon Seizures

(2013) A. Walczak et al.   JOURNAL OF NEUROSCIENCE

Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy

(2013) Gumei Liu et al.   NEURON

BDNF-induced local protein synthesis and synaptic plasticity

(2013) Graciano Leal et al.   NEUROPHARMACOLOGY

Changes in the sensitivity of GABAA current rundown to drug treatments in a model of temporal lobe epilepsy

(2013) Pierangelo Cifelli et al.   Frontiers in Cellular Neuroscience

Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures

(2010) Roberta Bovolenta et al.   Journal of Neuroinflammation

A simple role for BDNF in learning and memory?

(2010) Cunha   Frontiers in Molecular Neuroscience

Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease

(2009) Mark P. Mattson   Annals of the New York Academy of Sciences

Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model

(2009) Robert Kotloski et al.   HIPPOCAMPUS

Molecular and cellular basis of epileptogenesis in symptomatic epilepsy

(2008) Asla Pitkänen et al.   EPILEPSY & BEHAVIOR

The p.Val66Met polymorphism in the BDNF gene protects against early seizures in Rett syndrome

(2008) J. Nectoux et al.   NEUROLOGY

Peripherally-Derived BDNF Promotes Regeneration of Ascending Sensory Neurons after Spinal Cord Injury

(2008) Xing-Yun Song et al.   PLoS One