Tumor metabolic reprogramming in lung cancer progression (Review)

The hexosamine biosynthetic pathway and cancer: Current knowledge and future therapeutic strategies

(2021) Christine Lam et al.   CANCER LETTERS

Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model

(2021) Amanda Vannitamby et al.   Cancers

Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression

(2021) Shengchen Lin et al.   CANCER LETTERS

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

(2020) Jorge Simon et al.   Cell Metabolism

PFKP is highly expressed in lung cancer and regulates glucose metabolism

(2020) Jianfei Shen et al.   CELLULAR ONCOLOGY

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

(2019) Ayako Nagao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

(2019) Alessandro Carrer et al.   Cancer Discovery

Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells

(2019) Yilin Yu et al.   Cell Metabolism

Abandoning the Notion of Non-Small Cell Lung Cancer

(2019) Valeria Relli et al.   TRENDS IN MOLECULAR MEDICINE

Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis

(2019) Chunxia Xin et al.   MEDICAL SCIENCE MONITOR

A tumor agnostic therapeutic strategy for Hexokinase 1 Null/Hexokinase 2 positive cancers

(2019) Shili Xu et al.   CANCER RESEARCH

Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation

(2019) Jixiao Niu et al.   NATURE

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

(2019) Marteinn Thor Snaebjornsson et al.   Cell Metabolism

Phospholipids and cholesterol: Inducers of cancer multidrug resistance and therapeutic targets

(2019) Joanna Kopecka et al.   DRUG RESISTANCE UPDATES

FASN-TGF-β1-PD-L1 axis contributes to the development of resistance to NK cell cytotoxicity of cisplatin-resistant lung cancer cells

(2018) Mingjing Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

(2018) Mami Morita et al.   CANCER CELL

Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State

(2018) Anneleen Daemen et al.   Cell Metabolism

Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis

(2018) Tianyu Han et al.   CELL RESEARCH

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer

(2018) Azhar Ali et al.   EMBO Molecular Medicine

The impact of 27-hydroxycholesterol on endometrial cancer proliferation

(2018) Douglas A Gibson et al.   ENDOCRINE-RELATED CANCER

Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy

(2018) Xiao-Yan Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

High cholesterol in lipid rafts reduces the sensitivity to EGFR-TKI therapy in non-small cell lung cancer

(2018) Qiufang Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Liver X receptors in lipid signalling and membrane homeostasis

(2018) Bo Wang et al.   Nature Reviews Endocrinology

27-Hydroxycholesterol Inhibits Sterol Regulatory Element-Binding Protein 1 Activation and Hepatic Lipid Accumulation in Mice

(2018) Di Li et al.   Obesity

In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of 18F-(2S,4R)-4-Fluoroglutamine

(2018) Mark P. S. Dunphy et al.   RADIOLOGY

Glutaminase isoenzymes in the metabolic therapy of cancer

(2018) José M. Matés et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

(2018) Hongmei Zheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol

(2018) Shiro Hiramitsu et al.   Frontiers in Endocrinology

27-Hydroxycholesterol enhanced osteoclastogenesis in lung adenocarcinoma microenvironment

(2018) Lishan Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Amino acid synthesis deficiencies

(2017) T. J. de Koning   JOURNAL OF INHERITED METABOLIC DISEASE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fatty acid synthase – Modern tumor cell biology insights into a classical oncology target

(2017) Douglas Buckley et al.   PHARMACOLOGY & THERAPEUTICS

Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism

(2017) Balaraman Kalyanaraman   Redox Biology

Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth

(2017) Mariafrancesca Scalise et al.   Frontiers in Oncology

IDH mutations in cancer and progress toward development of targeted therapeutics

(2016) L. Dang et al.   ANNALS OF ONCOLOGY

Prognostic significance of serum LDH in small cell lung cancer: A systematic review with meta-analysis

(2016) Xiuxiu Zhang et al.   Cancer Biomarkers

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

(2016) Nagendra Sastry Yarla et al.   SEMINARS IN CANCER BIOLOGY

Correction to: ‘The Warburg Effect: How Does it Benefit Cancer Cells?’

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells

(2016) Jiajin Li et al.   Oncotarget

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

LXR ligands sensitize EGFR-TKI-resistant human lung cancer cells in vitro by inhibiting Akt activation

(2015) Ying Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

(2015) N. Jacque et al.   BLOOD

Molecular Pathways: Fatty Acid Synthase

(2015) S. F. Jones et al.   CLINICAL CANCER RESEARCH

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs

(2015) Michael Murray et al.   PHARMACOLOGY & THERAPEUTICS

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Plasma Metabolite Profiling and Chemometric Analyses of Lung Cancer along with Three Controls through Gas Chromatography-Mass Spectrometry

(2015) Syed Ghulam Musharraf et al.   Scientific Reports

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

Impact of Lung Cancer Screening Results on Smoking Cessation

(2014) Martin C. Tammemägi et al.   JNCI-Journal of the National Cancer Institute

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease

(2014) Behzad Yeganeh et al.   PHARMACOLOGY & THERAPEUTICS

Serine and glycine metabolism in cancer

(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Liver X Receptors Inhibit Proliferation of Human Colorectal Cancer Cells and Growth of Intestinal Tumors in Mice

(2013) Giuseppe Lo Sasso et al.   GASTROENTEROLOGY

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

(2013) C. Chen et al.   GENES & DEVELOPMENT

Glycolysis Inhibition Sensitizes Non-Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation

(2013) S. M. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

(2013) Ruiting Lin et al.   MOLECULAR CELL

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

MAX Inactivation in Small Cell Lung Cancer Disrupts MYC-SWI/SNF Programs and Is Synthetic Lethal with BRG1

(2013) O. A. Romero et al.   Cancer Discovery

Analysis of glutamine dependency in non-small cell lung cancer

(2012) A. Pieter J. van den Heuvel et al.   CANCER BIOLOGY & THERAPY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

Regulation of cholesterol biosynthesis and cancer signaling

(2012) Andrey Gorin et al.   CURRENT OPINION IN PHARMACOLOGY

Cancer: NF-κB regulates energy metabolism

(2012) Marta Moretti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

(2011) Y. Zhao et al.   CANCER RESEARCH

Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

(2010) Hua-shan Shi et al.   CANCER SCIENCE

Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model

(2010) Wenhao Guo et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

(2010) Ming Zhou et al.   Molecular Cancer

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE