Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression

Fascin actin-bundling protein 1 in human cancer: Promising biomarker or therapeutic target?

(2021) Hongliang Liu et al.   Molecular Therapy-Oncolytics

The FDA-Approved Antiviral Raltegravir Inhibits Fascin1-Dependent Invasion of Colorectal Tumor Cells In Vitro and In Vivo

(2021) Begoña Alburquerque-González et al.   Cancers

Mechanical regulation of glycolysis via cytoskeleton architecture

(2020) Jin Suk Park et al.   NATURE

How does fascin promote cancer metastasis?

(2020) Shengchen Lin et al.   FEBS Journal

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

(2019) Stuart Francis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

(2019) Mohamed Elgendy et al.   CANCER CELL

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

(2019) Shengchen Lin et al.   Cell Reports

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

(2019) Shengchen Lin et al.   EMBO Molecular Medicine

Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization

(2018) Tanya Schild et al.   CANCER CELL

Fascin induces melanoma tumorigenesis and stemness through regulating the Hippo pathway

(2018) Jiaxin Kang et al.   Cell Communication and Signaling

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

(2018) Hervé Tiriac et al.   Cancer Discovery

Interplay between YAP/TAZ and Metabolism

(2018) Ja Hyun Koo et al.   Cell Metabolism

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

FluxFix: automatic isotopologue normalization for metabolic tracer analysis

(2016) Sophie Trefely et al.   BMC BIOINFORMATICS

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

(2016) Hai Hu et al.   CELL

Monoubiquitination Inhibits the Actin Bundling Activity of Fascin

(2016) Shengchen Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving fascin inhibitors to block tumor cell migration and metastasis

(2016) Shaoqin Han et al.   Molecular Oncology

Fascin Is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway

(2016) Rayanah Barnawi et al.   STEM CELLS

Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP/TEAD signaling

(2016) Zhigang Liang et al.   TUMOR BIOLOGY

Validation of Metabolic Alterations in Microscale Cell Culture Lysates Using Hydrophilic Interaction Liquid Chromatography (HILIC)-Tandem Mass Spectrometry-Based Metabolomics

(2016) Venugopal Gunda et al.   PLoS One

Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization

(2015) Fang-Ke Huang et al.   Nature Communications

Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathway

(2014) H Ghebeh et al.   BRITISH JOURNAL OF CANCER

Hypoxia-Inducible Factor-1 Promotes Pancreatic Ductal Adenocarcinoma Invasion and Metastasis by Activating Transcription of the Actin-Bundling Protein Fascin

(2014) X. Zhao et al.   CANCER RESEARCH

Fascin Plays a Role in Stress Fiber Organization and Focal Adhesion Disassembly

(2014) Nadia Elkhatib et al.   CURRENT BIOLOGY

Fascin Is Regulated by Slug, Promotes Progression of Pancreatic Cancer in Mice, and Is Associated With Patient Outcomes

(2014) Ang Li et al.   GASTROENTEROLOGY

STIM1- and Orai1-mediated Ca2+oscillation orchestrates invadopodium formation and melanoma invasion

(2014) Jianwei Sun et al.   JOURNAL OF CELL BIOLOGY

GATA3 Transcription Factor Abrogates Smad4 Transcription Factor-mediated Fascin Overexpression, Invadopodium Formation, and Breast Cancer Cell Invasion

(2013) Jianwei Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Molecular Mechanism of Fascin Function in Filopodial Formation

(2012) Shengyu Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

(2012) Min Yuan et al.   Nature Protocols

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Fascin Protein Is Critical for Transforming Growth Factor β Protein-induced Invasion and Filopodia Formation in Spindle-shaped Tumor Cells

(2011) Jianwei Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Migrastatin analogues target fascin to block tumour metastasis

(2010) Lin Chen et al.   NATURE

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

(2009) Michel DuPage et al.   Nature Protocols

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Fascin1 is dispensable for mouse development but is favorable for neonatal survival

(2009) Yoshihiko Yamakita et al.   CELL MOTILITY AND THE CYTOSKELETON