Perindopril sensitizes hepatocellular carcinoma to chemotherapy: A possible role of leptin / Wnt/ β-catenin axis with subsequent inhibition of liver cancer stem cells

Supersaturated LFCS type III self-emulsifying delivery systems of sorafenib tosylate with improved biopharmaceutical performance: QbD-enabled development and evaluation

(2020) Teenu Sharma et al.   Drug Delivery and Translational Research

Enalapril overcomes chemoresistance and potentiates antitumor efficacy of 5-FU in colorectal cancer by suppressing proliferation, angiogenesis, and NF-κB/STAT3-regulated proteins

(2020) Yushan Yang et al.   Cell Death & Disease

miR-124 regulates liver cancer stem cells expansion and sorafenib resistance

(2020) Yun Feng et al.   EXPERIMENTAL CELL RESEARCH

M2 macrophages mediate sorafenib resistance by secreting HGF in a feed-forward manner in hepatocellular carcinoma

(2019) Ningning Dong et al.   BRITISH JOURNAL OF CANCER

Comparative effects of enalapril versus perindopril on serum levels of leptin and adiponectin in hypertensive patients

(2019) Rehab Werida et al.   ACTA CARDIOLOGICA

Wnt/β-Catenin Signaling in Liver Cancers

(2019) Wenhui Wang et al.   Cancers

Therapeutic Targeting of Cancer Stem Cells via Modulation of the Renin-Angiotensin System

(2019) Imogen M. Roth et al.   Frontiers in Oncology

Leptin-Induced Angiogenesis of EA.Hy926 Endothelial Cells via the Akt and Wnt Signaling Pathways In Vitro and In Vivo

(2019) Fei Yu et al.   Frontiers in Pharmacology

Perindopril, fosinopril and losartan inhibited the progression of diethylnitrosamine-induced hepatocellular carcinoma in mice via the inactivation of nuclear transcription factor kappa-B

(2018) Sameh Saber et al.   TOXICOLOGY LETTERS

Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinoma

(2018) Harshul Pandit et al.   BMC CANCER

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents

(2017) Giovanni Luca Beretta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Wnt/beta-catenin pathway: modulating anticancer immune response

(2017) Sachin Gopalkrishna Pai et al.   Journal of Hematology & Oncology

Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90

(2017) Mariko Yoshida et al.   Scientific Reports

Leptin Induces Mitosis and Activates the Canonical Wnt/β-Catenin Signaling Pathway in Neurogenic Regions of Xenopus Tadpole Brain

(2017) Melissa Cui Bender et al.   Frontiers in Endocrinology

EF Hand Protein IBA2 Promotes Cell Proliferation in Breast Cancers via Transcriptional Control of Cyclin D1

(2016) Y. Zhang et al.   CANCER RESEARCH

Wnt/β-catenin signaling and renin–angiotensin system in chronic kidney disease

(2016) Lili Zhou et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Hepatoma cell-derived leptin downregulates the immunosuppressive function of regulatory T-cells to enhance the anti-tumor activity of CD8+ T-cells

(2016) Renxiong Wei et al.   IMMUNOLOGY AND CELL BIOLOGY

Leptin-Notch signaling axis is involved in pancreatic cancer progression

(2016) Adriana Harbuzariu et al.   Oncotarget

PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression

(2015) Tao Luo et al.   Autophagy

Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma

(2015) E. A. Kuczynski et al.   CANCER RESEARCH

Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade

(2015) Dong-Xian Guan et al.   HEPATOLOGY

ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma

(2015) Kaori Tanaka et al.   Oncotarget

Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice

(2013) Magda Nasr et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Co-Expression of XIAP and Cyclin D1 Complex Correlates with a Poor Prognosis in Patients with Hepatocellular Carcinoma

(2012) Yufang Che et al.   AMERICAN JOURNAL OF PATHOLOGY

Leptin-induced Epithelial-Mesenchymal Transition in Breast Cancer Cells Requires β-Catenin Activation via Akt/GSK3- and MTA1/Wnt1 Protein-dependent Pathways

(2012) Dan Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma

(2009) Benoit Terris et al.   JOURNAL OF HEPATOLOGY

Expression of Notch1, Jagged1 and β-catenin and their clinicopathological significance in hepatocellular carcinoma

(2009) M. Wang et al.   NEOPLASMA

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

(2008) Taro Yamashita et al.   GASTROENTEROLOGY

Selective reduction in body fat mass and plasma leptin induced by angiotensin-converting enzyme inhibition in rats

(2008) M L Mathai et al.   INTERNATIONAL JOURNAL OF OBESITY

Development of Oxidative Stress by Cytochrome P450 Induction in Rodents Is Selective for Barbiturates and Related to Loss of Pyridine Nucleotide-dependent Protective Systems

(2008) Miroslav Dostalek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aldehyde Dehydrogenase Discriminates the CD133 Liver Cancer Stem Cell Populations

(2008) S. Ma et al.   MOLECULAR CANCER RESEARCH