Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade

Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway

(2013) Howard A. Burris   CANCER CHEMOTHERAPY AND PHARMACOLOGY

All-trans retinoic acid potentiates the chemotherapeutic effect of cisplatin by inducing differentiation of tumor initiating cells in liver cancer

(2013) Yang Zhang et al.   JOURNAL OF HEPATOLOGY

MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance

(2013) Katarina Zmajkovicova et al.   MOLECULAR CELL

Clinical Implications of Cancer Stem Cell Biology in Hepatocellular Carcinoma

(2012) Junfang Ji et al.   SEMINARS IN ONCOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Tumor Initiating Cells in Esophageal Squamous Cell Carcinomas Express High Levels of CD44

(2011) Jiang-Sha Zhao et al.   PLoS One

Data mining using the Catalogue of Somatic Mutations in Cancer BioMart

(2011) R. Shepherd et al.   Database-The Journal of Biological Databases and Curation

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

(2010) Jessie Villanueva et al.   CANCER CELL

Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines

(2010) Osamu Kimura et al.   CANCER SCIENCE

Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model

(2010) Yu-Xiong Feng et al.   HEPATOLOGY

All Trans Retinoic Acid and Cancer

(2010) Siddikuzzaman et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Epithelial Cell Adhesion Molecule Regulation Is Associated with the Maintenance of the Undifferentiated Phenotype of Human Embryonic Stem Cells

(2010) Tung-Ying Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

(2010) S Whittaker et al.   ONCOGENE

Phase 2 open-label study of single-agent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population

(2008) Thomas Yau et al.   CANCER

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

(2008) Taro Yamashita et al.   GASTROENTEROLOGY

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

(2008) Ann-Lii Cheng et al.   LANCET ONCOLOGY

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

(2008) J. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE