Hepatoma cell-derived leptin downregulates the immunosuppressive function of regulatory T-cells to enhance the anti-tumor activity of CD8+ T-cells

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Significant Roles of Regulatory T Cells and Myeloid Derived Suppressor Cells in Hepatitis B Virus Persistent Infection and Hepatitis B Virus-Related HCCs

(2015) Yasuteru Kondo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Tumor-associated antigen specific CD8+T cells in hepatocellular carcinoma – a promising target for immunotherapy

(2014) Nathalie Schmidt et al.   OncoImmunology

Co-culture of primary human tumor hepatocytes from patients with hepatocellular carcinoma with autologous peripheral blood mononuclear cells: study of their in vitro immunological interactions

(2013) Polyxeni P Doumba et al.   BMC GASTROENTEROLOGY

Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality

(2013) S. Kalathil et al.   CANCER RESEARCH

Hepatocellular Carcinoma from an Immunologic Perspective

(2013) T. F. Greten et al.   CLINICAL CANCER RESEARCH

Immunodominance and functional alterations of tumor-associated antigen-specific CD8+T-cell responses in hepatocellular carcinoma

(2013) Tobias Flecken et al.   HEPATOLOGY

Antitumor CD8+T cells in hepatocellular carcinoma: Present but exhausted

(2013) Ka-Kit Li et al.   HEPATOLOGY

Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model

(2013) Wenxiu Zhao et al.   LABORATORY INVESTIGATION

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer

(2012) Carlo Schneider et al.   GUT

Leptin revisited: its mechanism of action and potential for treating diabetes

(2012) Roberto Coppari et al.   NATURE REVIEWS DRUG DISCOVERY

The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages

(2012) Daria Capece et al.   Biomed Research International

Distinct anti-tumoral functions of adaptive immune cells in liver cancer

(2012) Carlo Schneider et al.   OncoImmunology

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Increased Frequency of CD4+CD25highFoxP3+ Regulatory T Cells in Patients with Hepatocellular Carcinoma

(2011) Xi Feng et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival

(2011) Q. Zheng et al.   ENDOCRINE-RELATED CANCER

Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma

(2011) Eishiro Mizukoshi et al.   HEPATOLOGY

Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice

(2011) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Leptin inhibits hepatocellular carcinoma proliferation via p38-MAPK-dependent signalling

(2011) Kyle J. Thompson et al.   HPB

Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow

(2010) Cherry Kam Chun Lo et al.   Cellular & Molecular Immunology

Immune Responses in Hepatocellular Carcinoma

(2010) Firouzeh Korangy et al.   DIGESTIVE DISEASES

Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis

(2010) Dipali Sharma et al.   HEPATOLOGY

PD-1 and PD-L1 upregulation promotes CD8+ T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients

(2010) Feng Shi et al.   INTERNATIONAL JOURNAL OF CANCER

Distinct Roles for the NK Cell-Activating Receptors in Mediating Interactions with Dendritic Cells and Tumor Cells

(2010) L.-E. Wai et al.   JOURNAL OF IMMUNOLOGY

Role of Leptin in the Activation of Immune Cells

(2010) Patricia Fernández-Riejos et al.   MEDIATORS OF INFLAMMATION

Leptin–leptin receptor are involved in angiogenesis in human hepatocellular carcinoma

(2008) Domenico Ribatti et al.   PEPTIDES

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA