Review
Oncology
Federico Selvaggi, Teresa Catalano, Roberto Cotellese, Gitana Maria Aceto
Summary: The incidence and mortality of PLCs are steadily increasing worldwide, with limited treatment options. Understanding the molecular aspects of PLCs is crucial for developing more efficient drugs and therapeutic strategies.
Article
Environmental Sciences
Ahmed G. Abd Elhameed, Manar G. Helal, Eman Said, Hatem A. Salem
Summary: The study demonstrated that saxagliptin can delay experimentally-induced hepatocellular carcinoma progression by improving liver function biomarkers and acting through the suppression of specific signaling pathways, enhancing tumor apoptosis, and suppressing proliferation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Cell Biology
Shi Wei, Miaomiao Dai, Chi Zhang, Kai Teng, Fengwei Wang, Hongbo Li, Weipeng Sun, Zihao Feng, Tiebang Kang, Xinyuan Guan, Ruihua Xu, Muyan Cai, Dan Xie
Summary: This study showed that KIF2C is significantly upregulated in HCC and associated with poor prognosis. Functional assays revealed that KIF2C promotes HCC cell proliferation, migration, invasion, and metastasis. Mechanistically, the study identified TBC1D7 as a binding partner of KIF2C, disrupting TSC complex formation and enhancing mTORC1 signaling.
Review
Microbiology
Teresa Catalano, Federico Selvaggi, Diana Liberata Esposito, Roberto Cotellese, Gitana Maria Aceto
Summary: Interaction between infectious agents and liver tissue can lead to pathological conditions that predispose individuals to development of primary liver cancers (PLCs), including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Infections such as hepatotropic viruses and oncogenic viruses can disrupt normal liver cell functions by affecting the Wnt/beta-catenin pathway. This review focuses on understanding how infectious agents can deregulate Wnt signaling and contribute to PLC development, and explores the potential of targeting the Wnt signaling pathway for novel therapeutic approaches.
Review
Oncology
Kaiting Wang, Xinyao Qiu, Yan Zhao, Hongyang Wang, Lei Chen
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating interactions among different components of the TME in hepatocellular carcinoma. Utilizing Wnt/beta-catenin mutations as a biomarker to predict resistance in immunotherapy holds significant clinical implications.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Liang-yun Li, Jun-fa Yang, Fan Rong, Zhi-pan Luo, Shuang Hu, Hui Fang, Ying Wu, Rui Yao, Wei-hao Kong, Xiao-wen Feng, Bang-jie Chen, Jun Li, Tao Xu
Summary: ZEB1 plays a crucial role in hepatocellular carcinoma (HCC) by promoting cell proliferation, migration, and invasion through activating the Wnt/β-catenin signaling pathway. Meanwhile, miR-708 inhibits the growth and metastasis of HCC cells by targeting ZEB1.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biotechnology & Applied Microbiology
Qingxian Wang, Yumei Tang, Yuansen Ge, Songming Zhang, Meiyuan Zheng
Summary: This study found that the long non-coding RNA NRAV plays a role in enhancing the viability, proliferation, and invasion of hepatocellular carcinoma (HCC) cells. Patients with high NRAV expression had a poor prognosis. Furthermore, NRAV may trigger the Wnt/beta-catenin signaling pathway by modulating the miR-199a-3p/CISD2 axis.
Article
Multidisciplinary Sciences
German Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Summary: RNF43/ZNRF3 alterations contribute to liver disease and liver cancer by affecting differentiation and lipid metabolism of hepatocytes. The loss of these genes leads to steatohepatitis and an increase in unsaturated lipids. Deletion of Rnf43/Znrf3 results in defective hepatocyte regeneration and liver cancer, causing an imbalance between differentiation and proliferation. Interestingly, ZNRF3 mutant liver cancer patients have a poorer prognosis and exhibit altered hepatic lipid metabolism and steatohepatitis/NASH signatures.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Gui-Feng Su, Ze-Xiu Huang, Deng-Liang Huang, Peng-Xiao Chen, Yao Wang, Yi-Fei Wang
Summary: Cepharanthine was found to inhibit cellular proliferation and invasion, and promote apoptosis in liver cancer cells. Mechanistic investigations revealed that cepharanthine suppressed the Hedgehog/Gli1 signaling pathway and inhibited Wnt/beta-catenin signaling, suggesting cepharanthine as a potential therapy for refractory liver cancer and other Wnt/Hedgehog-driven cancers.
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Oncology
Senwen Feng, Junhao Liu, Hailiang Li, Jianfan Wen, Yujun Zhao, Xiaofeng Li, Guankun Lu, Peng Gao, Xiancheng Zeng
Summary: RAD54B is significantly upregulated in HCC and may serve as a potential prognostic marker and therapeutic target; RAD54B promotes HCC progression mainly through modulating the Wnt/β-catenin signaling pathway; Inhibition of the Wnt/β-catenin signaling pathway can counteract the activating effects of RAD54B on the motility of HCC cells.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Elisa Lozano, Paula Sanchon-Sanchez, Ana Morente-Carrasco, Luis Miguel Chinchilla-Tabora, Jose L. Mauriz, Paula Fernandez-Palanca, Jose J. G. Marin, Rocio I. R. Macias
Summary: The poor prognosis of advanced cholangiocarcinoma (CCA) presents a significant challenge in modern oncology due to increasing incidence and late diagnosis. The heterogeneity of CCA subtypes and complex mechanisms involved in CCA contribute to the difficulty in treating this deadly tumor. The Wnt/beta-catenin pathway plays a crucial role, and understanding its alteration in relation to the heterogeneous forms of CCA is essential for advancing diagnostic and therapeutic strategies.
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zeliha Guney, Sivge Kurgan, Canan Onder, Mahmure Ayse Tayman, Oemer Gunhan, Alpdogan Kantarci, Muhittin Abdulkadir Serdar, Meral Gunhan
Summary: This study aimed to evaluate the activity of the Wnt/beta-catenin signaling pathway in gingival samples obtained from patients with periodontitis. The results showed that periodontal inflammation disrupts the Wnt/beta-catenin signaling pathway, leading to tissue inflammation and changes in morphology. This finding may shed light on the pathogenesis of periodontal disease.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Gastroenterology & Hepatology
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez
Summary: Intestinal PPAR alpha signaling modulates fatty acid uptake through regulating FABP1 expression, contributing to NASH progression. Targeting this pathway could be a potential therapeutic strategy for NASH treatment.
Article
Chemistry, Analytical
Xiao-Wei Xu, Ya Zhu, Jiang-Zhou Song, Gui-Qing Zou, Zhou Zhao, Qiu-Ling Zheng, Li-Juan Cao, Guang-Ji Wang, Hong Wang, Hai-Ping Hao
Summary: Investigated the expression differences of FXR in different organs and the influence of factors such as diet and circadian rhythm on FXR homeostasis. Developed a method for real-time monitoring of FXR expression in cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chujie Ding, Yu Hong, Yuan Che, Tianyu He, Yun Wang, Shule Zhang, Jiawei Wu, Wanfeng Xu, Jingyi Hou, Haiping Hao, Lijuan Cao
Summary: Cholestasis, a common complication of hepatitis B virus infection, has been found to negatively impact T cells response and hinder viral clearance. Bile acids disrupt calcium homeostasis, impairing T cells activation and signaling. Targeting bile acid regulation may be a therapeutic strategy for host-virus defense.
Article
Geosciences, Multidisciplinary
Ming Li, Lixia Li, Wenhui Wang
Summary: Well-preserved graptolites of the genus Kiaerograptus are reported for the first time in the Nanba section, Yiyang, Hunan Province, South China. Based on these new specimens, the Kiaerograptus biozone is established for the first time in South China, which has significant implications for biostratigraphical correlation.
ACTA GEOLOGICA SINICA-ENGLISH EDITION
(2023)
Article
Pharmacology & Pharmacy
Jiajia Shen, Huimin Guo, Shijia Liu, Wei Jin, Zhi-Wei Zhang, Yong Zhang, Keanqi Liu, Shuying Mao, Zhihao Zhou, Lin Xie, Guangji Wang, Haiping Hao, Yan Liang
Summary: This study identifies the crucial role of intestinal flora and microbiota metabolites in the occurrence and treatment of ischaemic stroke. The accumulation of branched-chain amino acids is closely associated with gut microflora dysbiosis and neuroinflammation. Lactobacillus helveticus and Lactobacillus brevis colonization exhibit neuroprotective activity and alleviate the accumulation of branched-chain amino acids.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shuang Cui, Huijian Hu, An Chen, Ming Cui, Xiaojie Pan, Pengfei Zhang, Guangji Wang, Hong Wang, Haiping Hao
Summary: The acetylation of FXR regulates its nucleocytoplasmic shuttling and degradation under conditions of liver injury, which limits the clinical benefits of FXR agonists. SIRT1 activators can reduce FXR acetylation and prevent its cytosolic degradation, and combining SIRT1 activators with FXR agonists shows promise in treating liver diseases.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Multidisciplinary Sciences
Weisheng Li, Xiaoshu Gong, Zhihao Yu, Liang Ma, Wenjie Sun, Si Gao, Cagil Koroglu, Wenfeng Wang, Lei Liu, Taotao Li, Hongkai Ning, Dongxu Fan, Yifei Xu, Xuecou Tu, Tao Xu, Litao Sun, Wenhui Wang, Junpeng Lu, Zhenhua Ni, Jia Li, Xidong Duan, Peng Wang, Yuefeng Nie, Hao Qiu, Yi Shi, Eric Pop, Jinlan Wang, Xinran Wang
Summary: By hybridizing with semi-metallic antimony (0112) through strong van der Waals interactions, the electrical contact of monolayer molybdenum disulfide is improved, meeting the requirements for the development of next-generation electronics.
Article
Oncology
Xiaodie Liu, Dingqing Feng, Wenhui Wang, Jing Liang, Huan Yu, Bin Ling
Summary: The study aimed to reveal the characteristics of immune infiltration in the tumor microenvironment of endometrial cancer (EC) and guide clinical decisions. Tregs and CD8 T cells were identified as protective factors for overall survival in EC. An immune-related prognosis risk index (IRPRI) was established, which could predict the response to immune checkpoint inhibitors in EC patients. The study also identified distinct clinical, immune, and mutation characteristics between different IRPRI groups.
JOURNAL OF IMMUNOTHERAPY
(2023)
Article
Geosciences, Multidisciplinary
Yong Wang, Joseph P. Botting, Jing-Qiang Tan, Ming Li, Wen-Hui Wang
Summary: Studies have shown that sponge communities in South China gradually expanded into deeper regions after the Late Ordovician Mass Extinction (LOME). The presence of these deep-water sponge assemblages indicates a shift in the redox state of the bottom-water from persistent anoxia or intermittent euxinia in the earliest Rhuddanian to oxygenation in the early Aeronian. The colonization of sponges in low-oxygen environments may have set the stage for the subsequent recovery of other benthic organisms.
JOURNAL OF PALAEOGEOGRAPHY-ENGLISH
(2023)
Article
Biochemistry & Molecular Biology
Peizheng Wen, Jun He, Qiong Zhang, Hongzhi Qi, Aoran Zhang, Daoming Liu, Quanguang Sun, Yongsheng Wang, Qi Li, Wenhui Wang, Zhanghao Chen, Yunlong Wang, Yuqiang Liu, Jianmin Wan
Summary: This study identifies a mutant in rice with heightened expression of SDG703, a histone methyltransferase, which leads to increased susceptibility to the small brown planthopper (SBPH). Transcriptomic analysis reveals that the overexpression of SDG703 suppresses the expression of defense-related genes involved in effector-triggered immunity (ETI) and pattern-triggered immunity (PTI) in plants. The findings suggest that histone methylation mediated by SDG703 plays a role in insect resistance in rice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Kang Wang, Yuecan Zhang, Guangji Wang, Haiping Hao, Hong Wang
Summary: Nonalcoholic fatty liver disease is a common liver disease without approved pharmacotherapy. Farnesoid X receptor (FXR) is considered a promising therapeutic target, but currently developed drugs have shown limited efficacy in clinical trials. This review summarizes the development of the FXR agonist obeticholic acid and discusses its limitations in depth.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Plant Sciences
Chao Tan, Mengxiao Liang, Qiong Luo, Tan Zhang, Wenhui Wang, Suxin Li, Shuzhen Men
Summary: We found that the auxin synthesis gene TAA1 and the auxin polar transport genes AUX1 and PIN3 collectively maintain fertility and seed size in Arabidopsis. These genes are expressed during gametophyte and seed development in Arabidopsis. Triple mutants of aux1, pin3, and taa1 exhibited severe reproductive defects with reduced silique elongation after anthesis. The development and morphology of the seeds were normal, but their size was smaller compared to the wild type.
Article
Cell & Tissue Engineering
Qingxia Zhang, Jing Liang, Dongkui Xu, Ting Gao, Jinku Zhang, Haiyan Liang, Wenhui Wang, Bin Ling, Dingqing Feng
Summary: The aim of this study was to identify the biological characteristics and potential roles of endometrial progenitor cells in the pathogenesis of endometriosis. Immunohistochemistry was used to assess the distribution of progenitor cells and expression of steroid hormone receptors in endometriosis. Progenitor cells were sorted and evaluated for clonogenicity, response to hormone treatment, and gene expression using various techniques including RNA sequencing.
CURRENT STEM CELL RESEARCH & THERAPY
(2023)
Article
Microbiology
Yuchen Wang, Xi Guo, Xinran Zhang, Ping Chen, Wenhui Wang, Shan Hu, Teng Ma, Xingchen Zhou, Dongming Li, Ying Yang
Summary: This study revealed 10 Candida species strains isolated from the first fatal case of rhinofacial and rhino-orbital-cerebral candidiasis. Whole-genome sequencing was used to differentiate the strains of Candida parapsilosis complex, with anti-fungal susceptibility testing revealing their susceptibility to all antifungal drugs. The analysis of antifungal-drug resistance genes provided insights into azole resistance in Candida tropicalis strains. These findings have significant implications for guiding clinical diagnosis and treatment.
Article
Psychology, Multidisciplinary
Haiping Hao, Xiaobao Li, Xi Shen, Hong Jiang, Haoyue Xiao, Houchao Lyu
Summary: This study examined the reciprocal relationship between future time perspective and self-control among adolescents. The results showed that future-negative and future-confusional were negatively related to self-control, while future-positive, future-perspicuity, future-perseverant, and future-planning were positively related to self-control. The study also found reciprocal relationships between future-confusional, future-planning, and self-control.
CURRENT PSYCHOLOGY
(2023)
