Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 Secretion

Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses

(2021) Yuan He et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sarbecovirus ORF6 proteins hamper the induction of interferon signaling

(2021) Izumi Kimura et al.   Cell Reports

SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response

(2021) Soo Jin Oh et al.   Cells

SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98

(2021) Amin Addetia et al.   mBio

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

(2021) Jin-Gu Lee et al.   Cell and Bioscience

Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment

(2021) Jun-yi Zhu et al.   Cell and Bioscience

Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo

(2021) Trinayan Kashyap et al.   ANTIVIRAL RESEARCH

SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block

(2021) James M. Burke et al.   RNA

SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate Immunity

(2021) Gianni Gori Savellini et al.   Viruses-Basel

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

(2021) Chia-Ming Su et al.   Scientific Reports

Antibody landscapes of SARS-CoV-2 can reveal novel vaccine and diagnostic targets

(2021) Asmaa Hachim et al.   Current Opinion in Virology

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Emerging coronaviruses: Genome structure, replication, and pathogenesis

(2020) Yu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients

(2020) Lirong Zou et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

(2020) Kenrie P Y Hui et al.   Lancet Respiratory Medicine

Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19

(2020) Adnan Shah   Frontiers in Immunology

Cytokine storm syndrome in coronavirus disease 2019: A narrative review

(2020) Y.‐M. Gao et al.   JOURNAL OF INTERNAL MEDICINE

The cytokine storm and COVID‐19

(2020) Biying Hu et al.   JOURNAL OF MEDICAL VIROLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein

(2020) Andrew D. Davidson et al.   Genome Medicine

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

(2020) Lisa Miorin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

(2020) David Olagnier et al.   Nature Communications

Alveolar epithelial cell type II as main target of SARS-CoV-2 virus and COVID-19 development via NF-Kb pathway deregulation: A physio-pathological theory

(2020) Maurizio Carcaterra et al.   MEDICAL HYPOTHESES

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production

(2020) Keli Chen et al.   Viruses-Basel

Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

(2018) Diego de Sá Coutinho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

(2017) Yong Hu et al.   JOURNAL OF VIROLOGY

A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus

(2016) Naoki Tajiri et al.   CNS Neuroscience & Therapeutics

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

(2016) Trinayan Kashyap et al.   Oncotarget

Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms

(2016) Yang Luo et al.   Frontiers in Immunology

Anti-inflammatory effect of resveratrol through the suppression of NF- B and JAK/STAT signaling pathways

(2015) C. Ma et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5

(2014) Stephanie Reikine et al.   Frontiers in Immunology

Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export

(2013) Sharon Kuss et al.   Viruses-Basel

Structural basis of innate immune recognition of viral RNA

(2012) Ian C. Berke et al.   CELLULAR MICROBIOLOGY