Alveolar epithelial cell type II as main target of SARS-CoV-2 virus and COVID-19 development via NF-Kb pathway deregulation: A physio-pathological theory

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

COVID-19: towards understanding of pathogenesis

(2020) Wei Cao et al.   CELL RESEARCH

Clinical Pathway for Early Diagnosis of COVID-19: Updates from Experience to Evidence-Based Practice

(2020) Guogang Xu et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

(2020) Tao Zhang et al.   CURRENT BIOLOGY

SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells

(2020) Soeren Lukassen et al.   EMBO JOURNAL

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

Why tocilizumab could be an effective treatment for severe COVID-19?

(2020) Binqing Fu et al.   Journal of Translational Medicine

Hospital-based use of thromboprophylaxis in patients with COVID-19

(2020) Alex C Spyropoulos et al.   LANCET

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

(2020) Luca Carsana et al.   LANCET INFECTIOUS DISEASES

COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

(2020) Muhammad Adnan Shereen et al.   Journal of Advanced Research

Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases

(2018) Alice Huertas et al.   EUROPEAN RESPIRATORY JOURNAL

The role of respiratory epithelium in host defence against influenza virus infection

(2018) Laura Denney et al.   Biomedical Journal

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Acute Respiratory Distress Syndrome

(2017) B. Taylor Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Drug delivery strategies to control macrophages for tissue repair and regeneration

(2016) Reham Garash et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

miR-429 is involved in regulation of NF-κBactivity by targeting IKKβ and suppresses oncogenic activity in cervical cancer cells

(2016) Jing-yi Fan et al.   FEBS LETTERS

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

(2016) Kobina Essandoh et al.   SHOCK

The pulmonary endothelium in acute respiratory distress syndrome: insights and therapeutic opportunities

(2016) Fraser R Millar et al.   THORAX

Recent Advances in Kawasaki Disease

(2016) Kyu Yeun Kim et al.   YONSEI MEDICAL JOURNAL

Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats

(2015) Marina Romaní-Pérez et al.   ENDOCRINOLOGY

Diverse macrophage populations mediate acute lung inflammation and resolution

(2014) Neil R. Aggarwal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

(2014) Andrew E. Vaughan et al.   NATURE

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment

(2013) S. K. P. Lau et al.   JOURNAL OF GENERAL VIROLOGY

Akt2 Deficiency Protects from Acute Lung Injury via Alternative Macrophage Activation and miR-146a Induction in Mice

(2013) E. Vergadi et al.   JOURNAL OF IMMUNOLOGY

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Elevated Serum Level of MicroRNA (miRNA)-200c and miRNA-371-5p in Children with Kawasaki Disease

(2013) Ki Wook Yun et al.   PEDIATRIC CARDIOLOGY

Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus

(2013) L. Josset et al.   mBio

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

(2012) Eugene D. Ponomarev et al.   GLIA

IL-6 Amplifier, NF- B-Triggered Positive Feedback for IL-6 Signaling, in Grafts Is Involved in Allogeneic Rejection Responses

(2012) J. Lee et al.   JOURNAL OF IMMUNOLOGY

Regulation of alveolar epithelial cell survival by the ACE-2/angiotensin 1–7/Mas axis

(2011) Bruce D. Uhal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

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(2011) Chun Liu et al.   MOLECULAR MEDICINE

Fatty diabetic lung: altered alveolar structure and surfactant protein expression

(2010) David J. Foster et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy

(2009) G. Y. Oudit et al.   DIABETES

MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases

(2009) Maria Angelica Cortez et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Bortezomib and Waldenstrom's macroglobulinemia

(2009) Laurent Pascal et al.   EXPERT OPINION ON PHARMACOTHERAPY

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

(2009) I. Glowacka et al.   JOURNAL OF VIROLOGY

Current perspectives in pulmonary surfactant — Inhibition, enhancement and evaluation

(2008) Yi Y. Zuo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES