Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review

Baicalin as an emerging magical nutraceutical molecule: Emphasis on pharmacological properties and advances in pharmaceutical delivery

(2022) Alaa Ibrahim et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation

(2022) Risha Ganguly et al.   World Journal of Hepatology

Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects

(2021) Qichao Hu et al.   PHARMACOLOGICAL RESEARCH

Baicalin-Induced Autophagy Preserved LPS-Stimulated Intestinal Cells from Inflammation and Alterations of Paracellular Permeability

(2021) Valentina Rizzo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatocellular Carcinoma Immune Landscape and the Potential of Immunotherapies

(2021) Julie Giraud et al.   Frontiers in Immunology

Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice

(2020) Jin Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway

(2020) Yuesheng Dong et al.   MOLECULES

Baicalin Protects Against 17α-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1α/Farnesoid X Receptor Pathway

(2020) Jinyu Yang et al.   Frontiers in Pharmacology

Protective effect of baicalin on the regulation of Treg/Th17 balance, gut microbiota and short-chain fatty acids in rats with ulcerative colitis

(2020) Lei Zhu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

HGF induces protective effects in α-naphthylisothiocyanate-induced intrahepatic cholestasis by counteracting oxidative stress

(2020) Soraya Salas-Silva et al.   BIOCHEMICAL PHARMACOLOGY

Baicalin Represses C/EBPβ via Its Antioxidative Effect in Parkinson’s Disease

(2020) Kecheng Lei et al.   Oxidative Medicine and Cellular Longevity

Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders

(2020) Daniel M. Chopyk et al.   GASTROENTEROLOGY

Factors Associated with Local Tumor Control and Complications after Thermal Ablation of Colorectal Cancer Liver Metastases: a 15-year Retrospective Cohort Study

(2020) I. Kurilova et al.   Clinical Colorectal Cancer

Fibrates for itch (FITCH) in fibrosing cholangiopathies: a double blind, randomized, placebo-controlled trial

(2020) Elsemieke de Vries et al.   GASTROENTEROLOGY

Key Players of Hepatic Fibrosis

(2020) Reham M. Dawood et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Terminalia bellirica (Gaertn.) roxb. (Bahera) in health and disease: A systematic and comprehensive review

(2020) Ashutosh Gupta et al.   PHYTOMEDICINE

Baicalin down-regulating hepatitis B virus transcription depends on the liver-specific HNF4α-HNF1α axis

(2020) Chengjie Xia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Tenofovir–disoproxil–fumarate modulates lipid metabolism via hepatic CD36/PPAR-alpha activation in hepatitis B virus infection

(2020) Kazuharu Suzuki et al.   JOURNAL OF GASTROENTEROLOGY

Baicalin induced colon cancer cells apoptosis through miR-217/DKK1-mediated inhibition of Wnt signaling pathway

(2019) Yanmei Jia et al.   MOLECULAR BIOLOGY REPORTS

Ameliorating efficacy of eugenol against metanil yellow induced toxicity in albino Wistar rats

(2019) Uma Kant Sharma et al.   FOOD AND CHEMICAL TOXICOLOGY

Gut microbiota, a new frontier to understand traditional Chinese medicines

(2019) Wuwen Feng et al.   PHARMACOLOGICAL RESEARCH

Resolution of ulcerative colitis

(2019) Markus F. Neurath et al.   Seminars in Immunopathology

Baicalin improves intestinal microecology and abnormal metabolism induced by high-fat diet

(2019) Minzi Ju et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulating effect of baicalin on IKK/IKB/NF-kB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis

(2019) Jian Shen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Baicalin relieves inflammation stimulated by lipopolysaccharide via upregulating TUG1 in liver cells

(2019) Yanqiu Huang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms

(2019) Ashutosh Gupta et al.   MOLECULES

Gut microbiota in phytopharmacology: A comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions

(2019) Priyankar Dey   PHARMACOLOGICAL RESEARCH

siRNA- and miRNA-based therapeutics for liver fibrosis

(2019) Zhen Zhao et al.   Translational Research

Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency

(2019) Amit Kumar Singh et al.   Nutrients

Baicalin Protects Against Hypertension-Associated Intestinal Barrier Impairment in Part Through Enhanced Microbial Production of Short-Chain Fatty Acids

(2019) Dandan Wu et al.   Frontiers in Pharmacology

Viral Hepatitis

(2019) Simone Lanini et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

The Comparative Study of the Therapeutic Effects and Mechanism of Baicalin, Baicalein, and Their Combination on Ulcerative Colitis Rat

(2019) Shuai Liang et al.   Frontiers in Pharmacology

Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC

(2018) Liang Shi et al.   BIOCHEMICAL PHARMACOLOGY

Baicalin attenuates diet induced nonalcoholic steatohepatitis by inhibiting inflammation and oxidative stress via suppressing JNK signaling pathways

(2018) Xueqing Zhong et al.   BIOMEDICINE & PHARMACOTHERAPY

The lncRNA CASC9 and RNA binding protein HNRNPL form a complex and co-regulate genes linked to AKT signaling

(2018) Marcel Klingenberg et al.   HEPATOLOGY

Baicalin inhibits PDGF-BB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration and activation via the miR-3595/ACSL4 axis

(2018) Xiongjian Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway

(2018) Qian Chen et al.   Journal of Natural Medicines

Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice

(2018) Junli Zhang et al.   LIFE SCIENCES

Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis

(2018) Jianye Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cinnamaldehyde, An active Component of Cinnamon provides Protection against Food colour induced Oxidative stress and Hepatotoxicity in albino Wistar rats

(2018) Uma Kant Sharma et al.   Vegetos

Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling

(2018) Zhou Wang et al.   Cell Death & Disease

Baicalin attenuates liver hypoxia/reoxygenation injury by inducing autophagy

(2018) Feng Liu et al.   Experimental and Therapeutic Medicine

Baicalin and puerarin reverse epithelial‑mesenchymal transition via the TGF‑β1/Smad3 pathway in�vitro

(2018) Tao Wu et al.   Experimental and Therapeutic Medicine

Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy

(2018) Amit Singh et al.   Nutrients

Baicalin, the major component of traditional Chinese medicine Scutellaria baicalensis induces colon cancer cell apoptosis through inhibition of oncomiRNAs

(2018) Yili Tao et al.   Scientific Reports

A potential role of Baicalin to inhibit apoptosis and protect against acute liver and kidney injury in rat preeclampsia model

(2018) Yonghong Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Drug-Induced Liver Injury: Highlights of the Recent Literature

(2018) Mark Real et al.   DRUG SAFETY

Fighting Liver Fibrosis with Naturally Occurring Antioxidants

(2018) Ligen Lin et al.   PLANTA MEDICA

Baicalin induces apoptosis in SW480 cells through downregulation of the SP1 transcription factor

(2018) Wenkang Ma et al.   ANTI-CANCER DRUGS

Flavocoxid exerts a potent antiviral effect against hepatitis B virus

(2017) Teresa Pollicino et al.   INFLAMMATION RESEARCH

The formation of a host-guest inclusion complex system between β-cyclodextrin and baicalin and its dissolution characteristics

(2017) Jing Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Baicalin may alleviate inflammatory infiltration in dextran sodium sulfate-induced chronic ulcerative colitis via inhibiting IL-33 expression

(2017) Cheng-Liang Zhang et al.   LIFE SCIENCES

Baicalin Ameliorates Experimental Liver Cholestasis in Mice by Modulation of Oxidative Stress, Inflammation, and NRF2 Transcription Factor

(2017) Kezhen Shen et al.   Oxidative Medicine and Cellular Longevity

Baicalin Ameliorates Liver Injury Induced by Chronic plus Binge Ethanol Feeding by Modulating Oxidative Stress and Inflammation via CYP2E1 and NRF2 in Mice

(2017) Ping He et al.   Oxidative Medicine and Cellular Longevity

Anti-DHAV-1 reproduction and immuno-regulatory effects of a flavonoid prescription on duck virus hepatitis

(2017) Yun Chen et al.   PHARMACEUTICAL BIOLOGY

Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs

(2017) Hai Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cautiously using natural medicine to treat liver problems

(2017) Fei Xiong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review

(2017) Wei Liang et al.   Aging and Disease

Baicalein Reduces Liver Injury Induced by Myocardial Ischemia and Reperfusion

(2016) Chang-Chi Lai et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Optimal staging system for predicting the prognosis of patients with hepatocellular carcinoma in China: a retrospective study

(2016) Lihui Su et al.   BMC CANCER

Analysis of association between circulating miR-122 and histopathological features of nonalcoholic fatty liver disease in patients free of hepatocellular carcinoma

(2016) Norio Akuta et al.   BMC GASTROENTEROLOGY

Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in Rats

(2016) Huifen Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics

(2016) Keumhan Noh et al.   MOLECULES

Protective effect of baicalin against experimental colitis via suppression of oxidant stress and apoptosis

(2016) Li-sheng Wang et al.   Pharmacognosy Magazine

Protection of baicalin against lipopolysaccharide induced liver and kidney injuries based on 1H NMR metabolomic profiling

(2016) Shanting Liao et al.   Toxicology Research

Baicalin promoted site-2 protease and not site-1 protease in endoplasmic reticulum stress-induced apoptosis of human hepatocellular carcinoma cells

(2016) Zhe Yu et al.   FEBS Open Bio

Baicalin Attenuates IL-17-Mediated Acetaminophen-Induced Liver Injury in a Mouse Model

(2016) Chia-Chih Liao et al.   PLoS One

Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats

(2015) Xiang-lan Wei et al.   BMC Complementary and Alternative Medicine

Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKKβ/AMPK/ACC Pathway

(2015) Youli Xi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Profiling and identification of the metabolites of baicalin and study on their tissue distribution in rats by ultra-high-performance liquid chromatography with linear ion trap-Orbitrap mass spectrometer

(2015) Jiayu Zhang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: From traditional uses to scientific data for its commercial exploitation

(2015) B. Dinda et al.   JOURNAL OF ETHNOPHARMACOLOGY

Recent advancement of molecular mechanisms of liver fibrosis

(2015) Ekihiro Seki et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Multiple ABC Transporters Efflux Baicalin

(2015) Bernadett Kalapos-Kovács et al.   PHYTOTHERAPY RESEARCH

Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin

(2015) H-Y Tan et al.   Cell Death & Disease

Effects of a combination of puerarin, baicalin and berberine on the expression of proliferator-activated receptor-γ and insulin receptor in a rat model of nonalcoholic fatty liver disease

(2015) WEIHAN ZHAO et al.   Experimental and Therapeutic Medicine

Baicalin attenuates TNBS-induced colitis in rats by modulating the Th17/Treg paradigm

(2014) Ying Zou et al.   ARCHIVES OF PHARMACAL RESEARCH

Baicalin protects PC-12 cells from oxidative stress induced by hydrogen peroxide via anti-apoptotic effects

(2014) Wen-xia Zheng et al.   BRAIN INJURY

Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

(2014) Haijun Chen et al.   CANCER LETTERS

The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation

(2014) Li Cui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative colitis patients

(2014) Feng-Yan Yu   WORLD JOURNAL OF GASTROENTEROLOGY

In VitroAntioxidant, Antibacterial, and Cytotoxic Activity andIn VivoEffect ofSyngonium podophyllumandEichhornia crassipesLeaf Extracts on Isoniazid Induced Oxidative Stress and Hepatic Markers

(2014) Shashank Kumar et al.   Biomed Research International

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

(2013) Ling Zhao et al.   International Journal of Nanomedicine

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Pretreatment of baicalin and wogonoside with glycoside hydrolase: A promising approach to enhance anticancer potential

(2013) CHUNHAO YU et al.   ONCOLOGY REPORTS

Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design

(2012) Jifu Hao et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

CaMKKβ Is Involved in AMP-Activated Protein Kinase Activation by Baicalin in LKB1 Deficient Cell Lines

(2012) Ying Ma et al.   PLoS One

Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect

(2011) Melissa D. Yang et al.   HEPATOLOGY

Simultaneous determination of eight active components in Chinese medicine ‘JiangYaBiFeng’ tablet by HPLC coupled with diode array detection

(2011) Ran Yang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro

(2011) XIANJIAO ZHANG et al.   ONCOLOGY REPORTS

Baicalin Down-regulates the Expression of Macrophage Migration Inhibitory Factor (MIF) Effectively for Rats with Ulcerative Colitis

(2011) Shi-Xue Dai et al.   PHYTOTHERAPY RESEARCH

Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARγ and inhibiting TGFβ1

(2010) Hongxiang Qiao et al.   PHARMACEUTICAL BIOLOGY

Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet

(2009) Hong-xia Guo et al.   ACTA PHARMACOLOGICA SINICA

Hepatic Contribution to a Marked Increase in the Plasma Concentration of Baicalin after Oral Administration of Its Aglycone, Baicalein, in Multidrug Resistance-Associated Protein 2-Deficient Rat

(2009) Teruaki Akao et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats

(2009) Viduranga Y. Waisundara et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro

(2009) Xin Mu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Intestinal Microbiota Regulate Xenobiotic Metabolism in the Liver

(2009) Britta Björkholm et al.   PLoS One

New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

(2008) Min Li-Weber   CANCER TREATMENT REVIEWS

Protective effect of baicalin against Lipopolysaccharide/d-galactosamine-induced liver injury in mice by up-regulation of Heme oxygenase-1

(2008) Jing-Yuan Wan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY