Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis

Effect of baicalin on GLUT4 expression and glucose uptake in myotubes of rats

(2018) Penghua Fang et al.   LIFE SCIENCES

Label-Free Digital Quantification of Lipid Droplets in Single Cells by Stimulated Raman Microscopy on a Microfluidic Platform

(2016) Chen Cao et al.   ANALYTICAL CHEMISTRY

Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling

(2016) Shan Zhao et al.   CHEMICAL COMMUNICATIONS

Oral pharmacokinetics of baicalin, wogonoside, oroxylin A 7- O -β- d -glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat

(2016) Yu Cai et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates

(2016) Lun K. Tsou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes

(2016) Siddharth Singh et al.   Nature Reviews Gastroenterology & Hepatology

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

The Hunger Genes: Pathways to Obesity

(2015) Agatha A. van der Klaauw et al.   CELL

Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKKβ/AMPK/ACC Pathway

(2015) Youli Xi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP)

(2015) Jigang Wang et al.   Scientific Reports

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

Luteolin Attenuates Hepatic Steatosis and Insulin Resistance Through the Interplay Between the Liver and Adipose Tissue in Mice with Diet-Induced Obesity

(2014) Eun-Young Kwon et al.   DIABETES

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

The pathophysiology of hypertension in patients with obesity

(2014) Vincent G. DeMarco et al.   Nature Reviews Endocrinology

The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase

(2014) J. M. Inloes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Phenotyping the effect of diet on non-alcoholic fatty liver disease

(2012) Nicole J.W. de Wit et al.   JOURNAL OF HEPATOLOGY

Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis inLdlr−/−mice

(2012) Julia M. Assini et al.   JOURNAL OF LIPID RESEARCH

Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet

(2011) Peng Pu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance

(2011) E. E. Mulvihill et al.   DIABETES

The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation

(2011) Emma Barroso et al.   ENDOCRINOLOGY

Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis

(2011) Julia Monsénégo et al.   JOURNAL OF HEPATOLOGY

Global profiling of dynamic protein palmitoylation

(2011) Brent R Martin et al.   NATURE METHODS

Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet

(2009) Hong-xia Guo et al.   ACTA PHARMACOLOGICA SINICA

Increased food energy supply is more than sufficient to explain the US epidemic of obesity

(2009) Boyd Swinburn et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Regulatory enzymes of mitochondrial β-oxidation as targets for treatment of the metabolic syndrome

(2009) M. Schreurs et al.   Obesity Reviews

A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels

(2008) Maja Stefanovic-Racic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Macromolecular Modeling with Rosetta

(2008) Rhiju Das et al.   Annual Review of Biochemistry

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

(2008) Paula Mera et al.   BIOCHEMICAL PHARMACOLOGY