Review
Medicine, General & Internal
Ying Wang, Dan Wang, Li Yang, Yi Zhang
Summary: Tumor-associated macrophages (TAMs) play a crucial role in the tumor immune microenvironment and have immunosuppressive functions. The metabolic reprogramming of TAMs has a significant impact on their function and phenotype, and targeting metabolism-related pathways shows potential as an anti-tumor therapy.
CHINESE MEDICAL JOURNAL
(2022)
Article
Oncology
Ryan C. Augustin, Sarah Newman, Aofei Li, Marion Joy, Maureen Lyons, Mary P. Pham, Peter Lucas, Katelyn Smith, Cindy Sander, Brian Isett, Diwakar Davar, Yana G. Najjar, Hassane M. Zarour, John M. Kirkwood, Jason John Luke, Riyue Bao
Summary: In this study, we characterized acral melanoma (AM) and investigated its response to immune checkpoint inhibitors (ICIs). We found differential gene expression and pathway activation in a non-T cell-inflamed tumor microenvironment (TME) of AM, which may contribute to its poor response to ICIs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Yaping Chen, Hao Huang, Yuan Li, Wenlu Xiao, Yingting Liu, Rongzhang Chen, Yulan Zhu, Xiao Zheng, Changping Wu, Lujun Chen
Summary: Combination immunotherapy based on immune checkpoint inhibitors (ICIs) has shown great success in cancer treatment, and the combination of ablation and immunotherapy has potential for the treatment of liver metastasis of colorectal cancer (CRC). The expression of TIGIT was up-regulated after microwave ablation (MWA), and the combination of MWA and TIGIT blockade significantly promoted the expansion and functions of CD8(+) tumor-infiltrating lymphocytes (TILs) and reshaped myeloid cells in the tumor microenvironment (TME).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Deqiang Wang, Xiaofeng Chen, Yian Du, Xiaoqin Li, Leqian Ying, Yi Lu, Bo Shen, Xuan Gao, Xin Yi, Xuefeng Xia, Xinbing Sui, Yongqian Shu
Summary: HER2 mutations may improve the tumor microenvironment to promote immunotherapy. A prospective basket trial is needed to further investigate the impacts of HER2 mutations on immunotherapy outcomes in solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Emily Maria Ploeg, Douwe Freerk Samplonius, Xiao Xiong, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Isabel Britsch, Anne Paulien van Wijngaarden, Hao Zhang, Wijnand Helfrich
Summary: CD73 is an enzyme that converts pro-inflammatory extracellular ATP from stressed cancer cells to anti-inflammatory adenosine. CD73 antagonistic antibodies are used to suppress immune checkpoints, but they may also affect normal cells. Therefore, a more selective approach is needed to inhibit CD73 specifically in cancer cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Camille Moeckel, Katrina Bakhl, Ilias Georgakopoulos-Soares, Apostolos Zaravinos
Summary: Cancer is a leading cause of death worldwide, and research on potential therapeutics, including immune checkpoint inhibitors (ICIs), has been extensive. Initially, programmed-death ligand-1 was used as a biomarker to predict the effectiveness of ICIs. However, the heterogeneous expression of this biomarker in the tumor microenvironment led to the exploration of tumor mutation burden (TMB).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Amalia Kotsifaki, Nektarios Alevizopoulos, Vassiliki Dimopoulou, Athanasios Armakolas
Summary: This review explores the role of the immune microenvironment in breast cancer, including its impact on initiation, progression, and metastasis. It highlights the complex mechanisms by which breast cancer cells interact with immune cells and discusses the potential biomarkers associated with the immune response. The review also discusses the therapeutic implications of targeting the immune microenvironment and the potential for novel treatment interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Clara Martori, Lidia Sanchez-Moral, Tony Paul, Juan Carlos Pardo, Albert Font, Vicenc Ruiz de Porras, Maria-Rosa Sarrias
Summary: Immunotherapy has limited efficacy in patients with metastatic prostate cancer due to the immunosuppressive tumor microenvironment, which includes tumor-associated macrophages. Targeting macrophages could offer a promising strategy to reduce tumor progression and enhance immunotherapy efficacy in the treatment of metastatic prostate cancer.
Review
Oncology
Vincenzo Salemme, Giorgia Centonze, Federica Cavallo, Paola Defilippi, Laura Conti
Summary: The progression of breast cancer is influenced by genetic and epigenetic factors that involve interactions between tumor cells and the tumor microenvironment, particularly immune cells. Immune cells in the tumor microenvironment can have dual roles in cancer onset and progression, affecting both tumor suppression and promotion. Understanding the complex interplay between cancer and immune cells, as well as therapeutic strategies targeting this interaction, is crucial for developing effective combination treatments to overcome tumor immune evasion mechanisms and maximize the clinical benefits of current immunotherapies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Medicinal
Habib Sadeghi Rad, James Monkman, Majid E. Warkiani, Rahul Ladwa, Ken O'Byrne, Nima Rezaei, Arutha Kulasinghe
Summary: Advances in immunotherapy have provided durable and long-term benefits for certain patients with solid tumors, with a key focus on understanding the immune landscape of the tumor microenvironment to develop effective immunotherapeutic strategies.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Oncology
Carla Faria, Fabien Gava, Pauline Gravelle, Juan Garcia Valero, Celia Dobano-Lopez, Nathalie Van Acker, Cathy Quelen, Gael Jalowicki, Renaud Morin, Cedric Rossi, Jean-Michel Lagarde, Jean-Jacques Fournie, Loic Ysebaert, Camille Laurent, Patricia Perez-Galan, Christine Bezombes
Summary: This study developed a patient-derived lymphoma spheroid (FL-PDLS) model to capture disease heterogeneity and microenvironment cues. The model cultured FL cells from lymph nodes with an optimized cytokine cocktail that mimics LN stimuli and maintains tumor cell viability.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Medicine, Research & Experimental
Katja Niesel, Michael Schulz, Julian Anthes, Tijna Alekseeva, Jadranka Macas, Anna Salamero-Boix, Aylin Moeckl, Timm Oberwahrenbrock, Marco Lolies, Stefan Stein, Karl H. Plate, Yvonne Reiss, Franz Roedel, Lisa Sevenich
Summary: The tumor microenvironment in brain metastases is characterized by high myeloid cell content associated with immune suppressive and cancer-permissive functions. Radio-immunotherapy resulted in an increase in cytotoxic T-cell numbers and prevented the induction of lymphocyte-mediated immune suppression. However, long-term efficacy was not observed.
EMBO MOLECULAR MEDICINE
(2021)
Article
Oncology
Roberto Moretto, Daniele Rossini, Aurelie Catteau, Carlotta Antoniotti, Mirella Giordano, Alessandra Boccaccino, Clara Ugolini, Agnese Proietti, Veronica Conca, Alboukadel Kassambara, Filippo Pietrantonio, Lisa Salvatore, Sara Lonardi, Stefano Tamberi, Emiliano Tamburini, Anello Marcello Poma, Jacques Fieschi, Gabriella Fontanini, Gianluca Masi, Jerome Galon, Chiara Cremolini
Summary: The expression of tumor-infiltrating lymphocytes (TILs), Immunoscore, Immunoscore-IC, and programmed death ligand-1 (PD-L1) can predict the efficacy of immune-checkpoint inhibitors (ICIs) in patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Olamide T. Olaoba, Funmilayo C. Ligali, Zaccheaus O. Alabi, Amos O. Akinyemi, Kehinde S. Ayinde
Summary: The immune evasive strategies of PDAC involve upregulation of co-inhibitory checkpoint receptors/ligands, enhancement of Tregs-mediated trogocytosis, and maintaining a high Tregs/CD(+)8 ratio in the TME, leading to low threshold of CD(+)8 cells. The development of therapeutic agents targeting immune checkpoints has been a major advancement in treating PDAC, however, the resistance mechanisms such as desmoplasia in the TME still pose challenges.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Oncology
Yuanyuan Yang, Weijie Zhang, Peixiang Lan
Summary: Macrophages play a crucial role in tumor progression. Understanding novel immune checkpoints on macrophages can help design personalized immunotherapies. This review provides a comprehensive summary of the immune checkpoints and receptor-ligand interactions between macrophages and tumor cells.
Article
Immunology
Caitlin Schneider, Connie Shen, Angelica A. Gopal, Todd Douglas, Benjamin Forestell, Keith D. Kauffman, Dakota Rogers, Patricio Artusa, Qian Zhang, Huie Jing, Alexandra F. Freeman, Daniel L. Barber, Irah L. King, Maya Saleh, Paul W. Wiseman, Helen C. Su, Judith N. Mandl
Review
Immunology
Thomas Daubon, Audrey Hemadou, Irati Romero Garmendia, Maya Saleh
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Oncology
J. Giraud, M. Foroutan, J. Boubaker-Vitre, F. Grillet, Z. Homayed, U. Jadhav, P. Crespy, C. Breuker, J-F. Bourgaux, J. Hazerbroucq, C. Pignodel, B. Brulin, R. A. Shivdasani, P. Jay, F. Hollande, J. Pannequin
Summary: Progastrin, produced by a subset of endocrine cells in intestinal crypts, transitions to being mainly sourced from intestinal stem cells in early adenomas, suggesting a feed-forward mechanism between progastrin and Wnt signaling as a hallmark of early neoplastic transformation in mouse and human colonic adenomas.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Immunology
Gael Galli, Maya Saleh
Summary: Macrophages play crucial roles in tissue homeostasis, inflammation, and host defense by recognizing microbial or danger signals and eliciting immune responses. The interaction between cellular metabolism and macrophage innate immunity involves metabolic adaptations that modulate immune signaling and macrophage function. Intracellular bacterial pathogens can exploit macrophage metabolic pathways to evade immune defenses. This review highlights recent evidence on host-bacterial immunometabolic interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Marc Scherlinger, Vivien Guillotin, Isabelle Douchet, Pierre Vacher, Andrea Boizard-Moracchini, Jean-Philippe Guegan, Anne Garreau, Nathalie Merillon, Agathe Vermorel, Emmanuel Ribeiro, Irene Machelart, Estibaliz Lazaro, Lionel Couzi, Pierre Duffau, Thomas Barnetche, Jean-Luc Pellegrin, Jean-Francois Viallard, Maya Saleh, Thierry Schaeverbeke, Patrick Legembre, Marie-Elise Truchetet, Helene Dumortier, Cecile Contin-Bordes, Vanja Sisirak, Christophe Richez, Patrick Blanco
Summary: This study identified a P-selectin-dependent pathway in patients with systemic lupus erythematosus (SLE) and validated it as a potential therapeutic avenue. Platelets from SLE patients interacted with Treg cells via the P-selectin/PSGL-1 axis, affecting Treg cell function and suppressing immune responses. Blocking P-selectin in a mouse model of SLE improved disease features, indicating its potential as a therapeutic target.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Allan Tran, Charlotte Scholtes, Mario Songane, Claudia Champagne, Luc Galarneau, Marie-Pier Levasseur, Nassima Fodil, Catherine Rosa Dufour, Vincent Giguere, Maya Saleh
Summary: ERR alpha plays a protective role in the intestine by promoting disease tolerance through transcriptional control of key genes involved in intestinal tissue homeostasis and repair. Loss of ERR alpha leads to increased colon inflammation and tissue damage.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Benjamin A. W. R. Ralph, Melanie Lehoux, Hanna Ostapska, Brendan D. D. Snarr, Alayna K. K. Caffrey-Carr, Richard Fraser, Maya Saleh, Joshua J. J. Obar, Salman T. T. Qureshi, Donald C. C. Sheppard
Summary: Aspergillus fumigatus airway infections in patients with chronic lung disease are associated with increased hospitalizations and declining lung function. IL-1 cytokines play a critical role in enhancing host resistance to A. fumigatus airway infection by suppressing neutrophil apoptosis at the site of infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Julie Giraud, Maya Saleh
Summary: Hepatocellular carcinoma (HCC) is a challenging liver cancer associated with alcoholic or non-alcoholic fatty liver diseases, where inflammation, tissue injury, and fibrosis are important precursors. Understanding the connections between microbiota, inflammation, and carcinogenesis in the context of HCC could lead to innovative microbial-based therapeutic strategies for liver cancer.
Review
Cell Biology
Heloise Tudela, Sandrine P. Claus, Maya Saleh
Summary: The gut microbiota, a diverse community of microorganisms in the gastrointestinal tract, has a significant impact on health and disease. Keystone species, essential microbes for microbiota balance, play crucial roles in maintaining essential functions and their identification is crucial for the development of microbiome-based therapeutics. Understanding the functions of keystone species is a major step towards comprehending microbiome dynamics in disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Eloise Ramel, Sebastian Lillo, Boutaina Daher, Marina Fioleau, Thomas Daubon, Maya Saleh
Summary: The study focuses on the metabolic programs of tumor-associated myeloid cells and how the cancerous metabolic environment modulates their functions, impacting anti-tumor immune responses and immune evasion mechanisms.
Article
Oncology
Julie Giraud, Lornella Seeneevassen, Benoit Rousseau, Damien Bouriez, Elodie Sifre, Alban Giese, Tra Ly Nguyen, Camille Tiffon, Yannick Lippi, Lamia Azzi-Martin, Julie Pannequin, Armelle Menard, Emilie Bessede, Cathy Staedel, Francis Megraud, Genevieve Belleannee, Philippe Lehours, Caroline Gronnier, Pierre Dubus, Christine Varon
Summary: This study identified CD44v3 as a specific marker expressed in gastric adenocarcinoma (GC), which possesses tumorigenic and metastatic properties. CD44v3+ cells were detected in adenomatous lesions of GC and exhibited tumor formation and migration capabilities in vitro and in vivo. The detection of CD44v3+ cells in primary tumors of GC patients was associated with poor prognosis.
Article
Physiology
Yannick Cyr, Valerie Lamantia, Simon Bissonnette, Melanie Burnette, Aurele Besse-Patin, Annie Demers, Martin Wabitsch, Michel Chretien, Gaetan Mayer, Jennifer L. Estall, Maya Saleh, May Faraj
Summary: This study found that normocholesterolemic subjects with lower plasma PCSK9 and higher WAT surface-expression of LDLR and CD36 have higher WAT NLRP3 inflammasome activation and T2D risk factors. This may be due to LDL-induced inhibition of adipocyte function.
PHYSIOLOGICAL REPORTS
(2021)