A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells

In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells

(2022) Bonnie Huang et al.   Nature Communications

PI3K inhibitors are finally coming of age

(2021) Bart Vanhaesebroeck et al.   NATURE REVIEWS DRUG DISCOVERY

PI3K in T Cell Adhesion and Trafficking

(2021) Kristoffer H. Johansen et al.   Frontiers in Immunology

Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones

(2020) Anne Chauveau et al.   IMMUNITY

DOCK8 is essential for LFA-1–dependent positioning of T follicular helper cells in germinal centers

(2020) Erin Janssen et al.   JCI Insight

The multifaceted functions of follicular regulatory T cells

(2020) Peter T Sage et al.   CURRENT OPINION IN IMMUNOLOGY

Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute

(2019) Binbin Wang et al.   Nature Protocols

High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging

(2019) Weizhe Li et al.   Nature Protocols

Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

(2019) Andrew J. M. Howden et al.   NATURE IMMUNOLOGY

An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

(2019) Chung Park et al.   eLife

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

(2018) James D. Phelan et al.   NATURE

Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches

(2018) Hristo Georgiev et al.   Frontiers in Immunology

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity

(2018) Silvia Preite et al.   NATURE IMMUNOLOGY

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

(2018) Anne-Katrien Stark et al.   Nature Communications

RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs

(2018) Bing Wu et al.   IMMUNITY

InterPro in 2019: improving coverage, classification and access to protein sequence annotations

(2018) Alex L Mitchell et al.   NUCLEIC ACIDS RESEARCH

ICAMs support B cell interactions with T follicular helper cells and promote clonal selection

(2017) Irina Zaretsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion

(2017) Felix J. Eppler et al.   PLoS One

The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance

(2016) Alexandre P. Meli et al.   IMMUNITY

PI3Kδ promotes CD4+ T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1

(2016) Fabien Garçon et al.   IMMUNOLOGY AND CELL BIOLOGY

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3Outside-in Signaling

(2016) Anthony M. Battram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis

(2015) Sayaka Ishihara et al.   Nature Communications

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Fibroblastic Reticular Cells Guide T Lymphocyte Entry into and Migration within the Splenic T Cell Zone

(2014) M. Bajenoff et al.   JOURNAL OF IMMUNOLOGY

Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion

(2014) Jun Yang et al.   Nature Communications

Specificity and Commonality of the Phosphoinositide-Binding Proteome Analyzed by Quantitative Mass Spectrometry

(2014) Stephanie Jungmichel et al.   Cell Reports

Rasa3 Controls Megakaryocyte Rap1 Activation, Integrin Signaling and Differentiation into Proplatelet

(2014) Patricia Molina-Ortiz et al.   PLoS Genetics

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

(2013) Klaus Okkenhaug   Annual Review of Immunology

A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes

(2013) Peter Reichardt et al.   EMBO JOURNAL

The Kindlin 3 Pleckstrin Homology Domain Has an Essential Role in Lymphocyte Function-associated Antigen 1 (LFA-1) Integrin-mediated B Cell Adhesion and Migration

(2013) Rosie Hart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the Role of Bcl6 in Follicular Th Cells Using a New Conditional Mutant Mouse Model

(2013) K. Hollister et al.   JOURNAL OF IMMUNOLOGY

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis

(2012) Gabriela Franco Salinas et al.   JOURNAL OF NEUROIMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

High endothelial venules as traffic control points maintaining lymphocyte population homeostasis in lymph nodes

(2011) C. Mionnet et al.   BLOOD

Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE

(2010) Sandra Gültner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction

(2010) J. Rolf et al.   JOURNAL OF IMMUNOLOGY

Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes

(2009) E. J. Park et al.   BLOOD

Vav Links the T Cell Antigen Receptor to the Actin Cytoskeleton and T Cell Activation Independently of Intrinsic Guanine Nucleotide Exchange Activity

(2009) Ana V. Miletic et al.   PLoS One

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase

(2009) M. Gigoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins

(2008) E. Y. Choi et al.   BLOOD

Intercellular Adhesion Molecule-1-Dependent Stable Interactions between T Cells and Dendritic Cells Determine CD8+ T Cell Memory

(2008) Alix Scholer et al.   IMMUNITY

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effector and suppressor roles for LFA-1 during the development of experimental autoimmune encephalomyelitis

(2008) Kari J. Dugger et al.   JOURNAL OF NEUROIMMUNOLOGY

Comprehensive Identification of PIP3-Regulated PH Domains from C. elegans to H. sapiens by Model Prediction and Live Imaging

(2008) Wei Sun Park et al.   MOLECULAR CELL

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY