The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3Outside-in Signaling

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphoinositide 3-Kinases p110α and p110β Have Differential Roles in Insulin-Like Growth Factor-1–Mediated Akt Phosphorylation and Platelet Priming

(2014) Thomas A. Blair et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

(2014) Matthias Canault et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of Platelet Activation and Thrombus Formation Using a Pan-PI3K Inhibitor S14161

(2014) Wenxiu Yi et al.   PLoS One

Rasa3 Controls Megakaryocyte Rap1 Activation, Integrin Signaling and Differentiation into Proplatelet

(2014) Patricia Molina-Ortiz et al.   PLoS Genetics

RhoG Protein Regulates Platelet Granule Secretion and Thrombus Formation in Mice

(2013) Robert Goggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKCα negatively regulatesin vitroproplatelet formation andin vivoplatelet production in mice

(2013) Christopher M. Williams et al.   PLATELETS

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Dysfunction of the PI3 kinase/Rap1/integrin  IIb 3 pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia

(2012) S. F. Moore et al.   BLOOD

Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis

(2012) Lionel Blanc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rap1-Rac1 Circuits Potentiate Platelet Activation

(2011) Lucia Stefanini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role and regulation of phosphatidylinositol 3-kinase   in platelet integrin  2 1 signaling

(2011) A. Consonni et al.   BLOOD

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes

(2011) J. W. Rowley et al.   BLOOD

Distinct Roles for Rap1b Protein in Platelet Secretion and Integrin αIIbβ3Outside-in Signaling

(2011) Guoying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

(2009) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human Platelets

(2009) Roger W. Hunter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversible binding and rapid diffusion of proteins in complex with inositol lipids serves to coordinate free movement with spatial information

(2009) Gerald R.V. Hammond et al.   JOURNAL OF CELL BIOLOGY

The Ability of GAP1IP4BP To Function as a Rap1 GTPase-Activating Protein (GAP) Requires Its Ras GAP-Related Domain and an Arginine Finger Rather than an Asparagine Thumb

(2009) S. Kupzig et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3

(2008) Naohide Watanabe et al.   JOURNAL OF CELL BIOLOGY