The multifaceted functions of follicular regulatory T cells

Dysregulated TFR and TFH cells correlate with B‐cell differentiation and antibody production in autoimmune hepatitis

(2020) Ma Liang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

(2020) Ine Vanderleyden et al.   Cell Reports

The Imbalance of Circulating Follicular Helper T Cells and Follicular Regulatory T Cells Is Associated With Disease Activity in Patients With Ulcerative Colitis

(2020) Yan Long et al.   Frontiers in Immunology

Bcl6 and Blimp1 reciprocally regulate ST2+ Treg–cell development in the context of allergic airway inflammation

(2020) Byunghee Koh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis

(2020) Yiding Li et al.   Frontiers in Immunology

Control of foreign Ag‐specific Ab responses by Treg and Tfr

(2020) James B. Wing et al.   IMMUNOLOGICAL REVIEWS

T follicular regulatory cells and IL-10 promote food antigen–specific IgE

(2020) Markus M. Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

An imbalance between blood CD4+CXCR5+Foxp3+ Tfr cells and CD4+CXCR5+Tfh cells may contribute to the immunopathogenesis of rheumatoid arthritis

(2020) Gan Cao et al.   MOLECULAR IMMUNOLOGY

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

(2019) Shenda Hou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis

(2019) Yin Yao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T follicular helper cells and T follicular regulatory cells in rheumatic diseases

(2019) Jun Deng et al.   Nature Reviews Rheumatology

Identification of a T follicular helper cell subset that drives anaphylactic IgE

(2019) Uthaman Gowthaman et al.   SCIENCE

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

(2019) Rachel L. Clement et al.   NATURE IMMUNOLOGY

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype

(2018) Chaoran Li et al.   CELL

Increased circulating CD4 + CXCR5 + FoxP3 + follicular regulatory T cells correlated with severity of systemic lupus erythematosus patients

(2018) Chen Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Spatial distribution and function of T follicular regulatory cells in human lymph nodes

(2018) Ismail Sayin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deficiency in T follicular regulatory cells promotes autoimmunity

(2018) Weiwei Fu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral imbalanced TFH/TFR ratio correlates with intrathecal IgG synthesis in multiple sclerosis at clinical onset

(2018) Marco Puthenparampil et al.   Multiple Sclerosis Journal

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

(2018) David Zemmour et al.   NATURE IMMUNOLOGY

Peripheral imbalanced TFH/TFR ratio correlates with intrathecal IgG synthesis in multiple sclerosis at clinical onset

(2018) Marco Puthenparampil et al.   Multiple Sclerosis Journal

T follicular regulatory cells are decreased in established treated rheumatoid arthritis patients with active disease

(2018) Vasco C Romão et al.   Arthritis & Rheumatology

The Ratio of Blood T Follicular Regulatory Cells to T Follicular Helper Cells Marks Ectopic Lymphoid Structure Formation While Activated Follicular Helper T Cells Indicate Disease Activity in Primary Sjögren's Syndrome

(2018) Valter R. Fonseca et al.   Arthritis & Rheumatology

Increased Circulating Follicular Treg Cells Are Associated With Lower Levels of Autoantibodies in Patients With Rheumatoid Arthritis in Stable Remission

(2018) Chen Liu et al.   Arthritis & Rheumatology

Imbalance of circulating Tfr/Tfh ratio in patients with rheumatoid arthritis

(2018) Xiuzhen Wang et al.   CLINICAL AND EXPERIMENTAL MEDICINE

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

(2017) Christoph Jandl et al.   Nature Communications

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice

(2016) Hao Wu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T follicular regulatory cells

(2016) Peter T. Sage et al.   IMMUNOLOGICAL REVIEWS

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

(2016) Peter T Sage et al.   NATURE IMMUNOLOGY

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells

(2016) Meryem Aloulou et al.   Nature Communications

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4

(2014) James Badger Wing et al.   IMMUNITY

The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells

(2014) Peter T. Sage et al.   IMMUNITY

Circulating T follicular regulatory and helper cells have memory-like properties

(2014) Peter T. Sage et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunoglobulin E plays an immunoregulatory role in lupus

(2014) Barbara Dema et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoreactive IgE Is Prevalent in Systemic Lupus Erythematosus and Is Associated with Increased Disease Activity and Nephritis

(2014) Barbara Dema et al.   PLoS One

Interleukin-21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice

(2014) Yanna Ding et al.   Arthritis & Rheumatology

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

(2012) Peter T Sage et al.   NATURE IMMUNOLOGY

Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells

(2011) I. Wollenberg et al.   JOURNAL OF IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE