Regulatory Role of CD4+ T Cells in Myocarditis

Interleukin-37 Ameliorates Coxsackievirus B3-induced Viral Myocarditis by Modulating the Th17/Regulatory T cell Immune Response

(2017) Bang An et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis

(2017) Xiaotong Cui et al.   JOURNAL OF IMMUNOLOGY

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells

(2017) Katrien Van der Borght et al.   Cell Reports

The Optimal Intervention Time of Bone Marrow Mesenchymal Stem Cells in Ameliorating Cardiac Fibrosis Induced by Viral Myocarditis: A Randomized Controlled Trial in Mice

(2017) Tingting Wu et al.   Stem Cells International

Ebi3 Prevents Trypanosoma cruzi-Induced Myocarditis by Dampening IFN-γ-Driven Inflammation

(2017) Tiago Silva Medina et al.   Frontiers in Immunology

Halofuginone alleviates acute viral myocarditis in suckling BALB/c mice by inhibiting TGF-β1

(2016) Xiao-Hua Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis

(2016) Przemyslaw Blyszczuk et al.   EUROPEAN HEART JOURNAL

Autoimmunity Against the Heart and Cardiac Myosin in Children With Myocarditis

(2016) Kathleen E. Simpson et al.   JOURNAL OF CARDIAC FAILURE

Inhibition of microRNA-155 ameliorates experimental autoimmune myocarditis by modulating Th17/Treg immune response

(2016) Lianhua Yan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy

(2016) Stephane Heymans et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

(2016) Katrin Klocke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Valproic acid ameliorates coxsackievirus-B3-induced viral myocarditis by modulating Th17/Treg imbalance

(2016) Haibin Jin et al.   Virology Journal

Effect and Mechanism of QiShenYiQi Pill on Experimental Autoimmune Myocarditis Rats

(2016) Shichao Lv et al.   MEDICAL SCIENCE MONITOR

Monocytic myeloid-derived suppressor cells from females, but not males, alleviate CVB3-induced myocarditis by increasing regulatory and CD4+IL-10+ T cells

(2016) Nan Su et al.   Scientific Reports

Regulatory T-cells in autoimmune diseases: Challenges, controversies and—yet—unanswered questions

(2015) Charlotte R. Grant et al.   AUTOIMMUNITY REVIEWS

Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance

(2015) Hiroyuki Takaba et al.   CELL

T Cells: Soldiers and Spies--The Surveillance and Control of Effector T Cells by Regulatory T Cells

(2015) B. M. Hall   Clinical Journal of the American Society of Nephrology

mTORC1 signaling is crucial for regulatory T cells to suppress macrophage-mediated inflammatory response after acute myocardial infarction

(2015) Keping Yang et al.   IMMUNOLOGY AND CELL BIOLOGY

Treg responses are associated with PM2.5-induced exacerbation of viral myocarditis

(2015) Yuquan Xie et al.   INHALATION TOXICOLOGY

Aire controls gene expression in the thymic epithelium with ordered stochasticity

(2015) Matthew Meredith et al.   NATURE IMMUNOLOGY

Immunopathogenesis of Myocarditis: The Interplay Between Cardiac Fibroblast Cells, Dendritic Cells, Macrophages and CD4+T Cells

(2015) B. Prince Amoah et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

P2×7 purinergic signaling in dilated cardiomyopathy induced by auto-immunity against muscarinic M2 receptors: autoantibody levels, heart functionality and cytokine expression

(2015) Camila Guerra Martinez et al.   Scientific Reports

Administration of regulatory T cells ameliorates myocardial inflammation in experimental myocarditis

(2014) K. Pappritz et al.   EUROPEAN HEART JOURNAL

Prognostic Value of Circulating Regulatory T Cells for Worsening Heart Failure in Heart Failure Patients With Reduced Ejection Fraction

(2014) Naoko Okamoto et al.   International Heart Journal

Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGF -Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis

(2014) M.-L. Chen et al.   JOURNAL OF IMMUNOLOGY

Programmed Death Ligand 1 Regulates a Critical Checkpoint for Autoimmune Myocarditis and Pneumonitis in MRL Mice

(2014) J. A. Lucas et al.   JOURNAL OF IMMUNOLOGY

CD11b+ Monocytes Abrogate Th17 CD4+ T Cell-Mediated Experimental Autoimmune Myocarditis

(2014) A. Valaperti et al.   JOURNAL OF IMMUNOLOGY

Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells

(2014) G. Shi et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells enhance mesenchymal stem cell survival and proliferation following autologous cotransplantation in ischemic myocardium

(2014) Yifu Zhou et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Proinflammatory Effects of Interferon Gamma in Mouse Adenovirus 1 Myocarditis

(2014) Mary K. McCarthy et al.   JOURNAL OF VIROLOGY

Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice

(2014) Kazuko Tajiri et al.   LIFE SCIENCES

Myocardial Gene Expression ofT-bet,GATA-3,Ror-γt,FoxP3, and Hallmark Cytokines in Chronic Chagas Disease Cardiomyopathy: An Essentially Unopposed TH1-Type Response

(2014) Luciana Gabriel Nogueira et al.   MEDIATORS OF INFLAMMATION

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

(2014) H. S. Kuehn et al.   SCIENCE

Control of inflammatory heart disease by CD4+T cells

(2013) Jobert G. Barin et al.   Annals of the New York Academy of Sciences

Innate Signaling Promotes Formation of Regulatory Nitric Oxide–Producing Dendritic Cells Limiting T-Cell Expansion in Experimental Autoimmune Myocarditis

(2013) Gabriela Kania et al.   CIRCULATION

T helper cells plasticity in inflammation

(2013) Lorenzo Cosmi et al.   CYTOMETRY PART A

Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

(2013) A. L. P. Caforio et al.   EUROPEAN HEART JOURNAL

Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy

(2013) Juliana F. Vasconcelos et al.   FASEB JOURNAL

Role of regulatory T cells during virus infection

(2013) Tamara Veiga-Parga et al.   IMMUNOLOGICAL REVIEWS

Helper T-cell identity and evolution of differential transcriptomes and epigenomes

(2013) Golnaz Vahedi et al.   IMMUNOLOGICAL REVIEWS

T-regulatory cell treatment prevents chronic rejection of heart allografts in a murine mixed chimerism model

(2013) Nina Pilat et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Fatal Eosinophilic Myocarditis Develops in the Absence of IFN-  and IL-17A

(2013) J. G. Barin et al.   JOURNAL OF IMMUNOLOGY

The plasticity of human Treg and Th17 cells and its role in autoimmunity

(2013) Markus Kleinewietfeld et al.   SEMINARS IN IMMUNOLOGY

Vaccination with Flt3L-induced CD8α+ dendritic cells prevents CD4+ T helper cell-mediated experimental autoimmune myocarditis

(2013) Alan Valaperti et al.   VACCINE

Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells

(2012) A.-P. Papageorgiou et al.   CARDIOVASCULAR RESEARCH

Autoantibodies in Heart Failure and Cardiac Dysfunction

(2012) Ziya Kaya et al.   CIRCULATION RESEARCH

Susceptibility to autoimmune myocarditis is associated with intrinsic differences in CD4+T cells

(2012) P. Chen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Update on coxsackievirus B3 myocarditis

(2012) DeLisa Fairweather et al.   CURRENT OPINION IN RHEUMATOLOGY

Circulating levels of interleukin-17 and cardiovascular outcomes in patients with acute myocardial infarction

(2012) Tabassome Simon et al.   EUROPEAN HEART JOURNAL

Long-term benefits of immunoadsorption in β1-adrenoceptor autoantibody-positive transplant candidates with dilated cardiomyopathy

(2012) Michael Dandel et al.   EUROPEAN JOURNAL OF HEART FAILURE

Autoimmunity against M2muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype

(2012) Akihiro Yoshizawa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy

(2012) Veronika Nindl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Foxp3+CD25high CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity

(2012) F.F. de Araújo et al.   IMMUNOBIOLOGY

PD-1 Protects against Inflammation and Myocyte Damage in T Cell-Mediated Myocarditis

(2012) M. L. Tarrio et al.   JOURNAL OF IMMUNOLOGY

The Number of Regulatory T Cells Correlates with Hemodynamic Improvement in Patients with Inflammatory Dilated Cardiomyopathy After Immunoadsorption Therapy

(2012) D. Bulut et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Deficient Regulatory T Cell Activity and Low Frequency of IL-17-Producing T Cells Correlate with the Extent of Cardiomyopathy in Human Chagas' Disease

(2012) Paulo Marcos Matta Guedes et al.   PLoS Neglected Tropical Diseases

IL-17RA Signaling Reduces Inflammation and Mortality during Trypanosoma cruzi Infection by Recruiting Suppressive IL-10-Producing Neutrophils

(2012) Jimena Tosello Boari et al.   PLoS Pathogens

Regulatory T cells ameliorate cardiac remodeling after myocardial infarction

(2011) Ting-Ting Tang et al.   BASIC RESEARCH IN CARDIOLOGY

The Diagnostic and Clinical Significance of Anti-Muscarinic Receptor Autoantibodies

(2011) Udi Nussinovitch et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Expression of functional T-cell markers and T-cell receptor Vbeta repertoire in endomyocardial biopsies from patients presenting with acute myocarditis and dilated cardiomyopathy

(2011) Michel Noutsias et al.   EUROPEAN JOURNAL OF HEART FAILURE

Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans

(2011) HuiJuan Lv et al.   JOURNAL OF CLINICAL INVESTIGATION

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis

(2011) Yuquan Xie et al.   VIROLOGY

Regulatory T Cells Protect Mice Against Coxsackievirus-Induced Myocarditis Through the Transforming Growth Factor β–Coxsackie-Adenovirus Receptor Pathway

(2010) Yu Shi et al.   CIRCULATION

Interleukin-17A Is Dispensable for Myocarditis but Essential for the Progression to Dilated Cardiomyopathy

(2010) G. Christian Baldeviano et al.   CIRCULATION RESEARCH

The Th17/Treg imbalance exists in patients with heart failure with normal ejection fraction and heart failure with reduced ejection fraction

(2010) Na Li et al.   CLINICA CHIMICA ACTA

Human regulatory T cells in autoimmune diseases

(2010) Gregory L Cvetanovich et al.   CURRENT OPINION IN IMMUNOLOGY

Low responder T cell susceptibility to the suppressive function of regulatory T cells in patients with dilated cardiomyopathy

(2010) H. Tang et al.   HEART

Human Th17 Cells Comprise Heterogeneous Subsets Including IFN- -Producing Cells with Distinct Properties from the Th1 Lineage

(2010) K. Boniface et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CTLA-4-B7 Interaction Suppresses Th17 Cell Differentiation

(2010) H. Ying et al.   JOURNAL OF IMMUNOLOGY

Th17 Cells Contribute to Viral Replication in Coxsackievirus B3-Induced Acute Viral Myocarditis

(2010) J. Yuan et al.   JOURNAL OF IMMUNOLOGY

IL-35-mediated induction of a potent regulatory T cell population

(2010) Lauren W Collison et al.   NATURE IMMUNOLOGY

IL-17 Produced during Trypanosoma cruzi Infection Plays a Central Role in Regulating Parasite-Induced Myocarditis

(2010) Paulo Marcos da Matta Guedes et al.   PLoS Neglected Tropical Diseases

Spontaneous autoimmune myocarditis and cardiomyopathy in HLA-DQ8.NODAbo transgenic mice

(2009) Veena Taneja et al.   JOURNAL OF AUTOIMMUNITY

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

(2009) Jhoanne L Bautista et al.   NATURE IMMUNOLOGY

Myocarditis

(2009) Leslie T. Cooper   NEW ENGLAND JOURNAL OF MEDICINE

Identification of IL-17-producing FOXP3+ regulatory T cells in humans

(2009) K. S. Voo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical implications of anti-heart autoantibodies in myocarditis and dilated cardiomyopathy

(2008) Alida L. P. Caforio et al.   AUTOIMMUNITY

Gonadectomy of male BALB/c mice increases Tim-3+ alternatively activated M2 macrophages, Tim-3+ T cells, Th2 cells and Treg in the heart during acute coxsackievirus-induced myocarditis

(2008) Sylvia Frisancho-Kiss et al.   BRAIN BEHAVIOR AND IMMUNITY

Prominin-1+/CD133+ bone marrow-derived heart-resident cells suppress experimental autoimmune myocarditis

(2008) Gabriela Kania et al.   CARDIOVASCULAR RESEARCH

Coxsackievirus B3-induced myocarditis: Infection of females during the estrus phase of the ovarian cycle leads to activation of T regulatory cells

(2008) S.A. Huber   VIROLOGY