Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation

The role of TOR in autophagy regulation from yeast to plants and mammals

(2014) Sandra Díaz-Troya et al.   Autophagy

Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart

(2013) Bénédicte Demeulder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

(2013) Joerg Betschinger et al.   CELL

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

(2013) Constance S. Petit et al.   JOURNAL OF CELL BIOLOGY

Cardiovascular science: opportunities for translating research into improved care

(2013) Eugene Braunwald   JOURNAL OF CLINICAL INVESTIGATION

Genetic mutations and mechanisms in dilated cardiomyopathy

(2013) Elizabeth M. McNally et al.   JOURNAL OF CLINICAL INVESTIGATION

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart

(2013) Nirmala Hariharan et al.   PLoS One

Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia

(2012) Sebastiano Sciarretta et al.   CIRCULATION

Interplay Between Heart and Skeletal Muscle Disease in Heart Failure

(2012) Elizabeth M. McNally et al.   CIRCULATION RESEARCH

AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart

(2012) Vlad G. Zaha et al.   CIRCULATION RESEARCH

Birt–Hogg–Dubé: tumour suppressor function and signalling dynamics central to folliculin

(2012) Andrew R. Tee et al.   Familial Cancer

Birt–Hogg–Dubé syndrome: from gene discovery to molecularly targeted therapies

(2012) Laura S. Schmidt   Familial Cancer

Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy

(2012) Aaron M. Beedle et al.   JOURNAL OF CLINICAL INVESTIGATION

Birt–Hogg–Dubé syndrome: clinicopathological features of the lung

(2012) Mitsuko Furuya et al.   JOURNAL OF CLINICAL PATHOLOGY

Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

(2012) Hisashi Hasumi et al.   JNCI-Journal of the National Cancer Institute

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(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The metabolic basis of kidney cancer

(2012) W. Marston Linehan et al.   SEMINARS IN CANCER BIOLOGY

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

(2012) R. K. Nookala et al.   Open Biology

Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice

(2011) Pankaj Shende et al.   CIRCULATION

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(2011) Saloua El Messaoudi et al.   CURRENT OPINION IN LIPIDOLOGY

Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin

(2011) A. J. Malhowski et al.   HUMAN MOLECULAR GENETICS

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2010) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Absence of the Birt–Hogg–Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility

(2010) R S Preston et al.   ONCOGENE

Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization

(2010) Seung-Beom Hong et al.   PLoS One

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

(2009) Yasumasa Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

(2009) Y. Hasumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization of a novel folliculin-interacting protein FNIP2

(2008) Hisashi Hasumi et al.   GENE

AMP Activated Protein Kinase-α2 Deficiency Exacerbates Pressure-Overload–Induced Left Ventricular Hypertrophy and Dysfunction in Mice

(2008) Ping Zhang et al.   HYPERTENSION

Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function

(2008) Wei-Hua Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes

(2008) Yanni Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Kidney-Targeted Birt-Hogg-Dube Gene Inactivation in a Mouse Model: Erk1/2 and Akt-mTOR Activation, Cell Hyperproliferation, and Polycystic Kidneys

(2008) M. Baba et al.   JNCI-Journal of the National Cancer Institute

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

(2008) Y Takagi et al.   ONCOGENE