Genetic alterations and oxidative stress in T cell lymphomas

The Th9 Axis Reduces the Oxidative Stress and Promotes the Survival of Malignant T Cells in Cutaneous T-Cell Lymphoma Patients

(2020) Sushant Kumar et al.   MOLECULAR CANCER RESEARCH

Mitochondrial Calcium Regulation of Redox Signaling in Cancer

(2020) Céline Delierneux et al.   Cells

Role of PI3K/AKT pathway in cancer: the framework of malignant behavior

(2020) Ningni Jiang et al.   MOLECULAR BIOLOGY REPORTS

STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK− ALCL

(2020) Emma I. Andersson et al.   Cancers

New Insights Into the Complex Mutational Landscape of Sézary Syndrome

(2020) Abu-Sayeef Mirza et al.   Frontiers in Oncology

Clinical significance of CD28 gene‐related activating alterations in adult T‐cell leukaemia/lymphoma

(2020) Yuma Sakamoto et al.   BRITISH JOURNAL OF HAEMATOLOGY

The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas

(2019) Rein Willemze et al.   BLOOD

Aspirin Inhibits Natural Killer/T-Cell Lymphoma by Modulation of VEGF Expression and Mitochondrial Function

(2019) Hongyu Zhang et al.   Frontiers in Oncology

Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma

(2019) Tayla B. Heavican et al.   BLOOD

Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling

(2019) Yosaku Watatani et al.   LEUKEMIA

The pathological features of angioimmunoblastic T-cell lymphomas with IDH2R172 mutations

(2019) Julia Steinhilber et al.   MODERN PATHOLOGY

Fluorescence In Situ Hybridization for TP63 Rearrangements in T‐cell Lymphomas: Single Site Experience of 470 Patients and Implications for Clinical Testing

(2019) Jess F. Peterson et al.   HISTOPATHOLOGY

Angioimmunoblastic T‐cell lymphoma contains multiple clonal T‐cell populations derived from a common TET2 mutant progenitor cell

(2019) Wen‐Qing Yao et al.   JOURNAL OF PATHOLOGY

Ascorbyl stearate and ionizing radiation potentiate apoptosis through intracellular thiols and oxidative stress in murine T lymphoma cells

(2018) Shirish D. Mane et al.   CHEMICO-BIOLOGICAL INTERACTIONS

New insights in the pathogenesis of T-cell lymphomas

(2018) François Lemonnier et al.   CURRENT OPINION IN ONCOLOGY

SATB1 Defines a Subtype of Cutaneous CD30 + Lymphoproliferative Disorders Associated with a T-Helper 17 Cytokine Profile

(2018) Jingru Sun et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Overlap at the molecular and immunohistochemical levels between angioimmunoblastic T-cell lymphoma and a subgroup of peripheral T-cell lymphomas without specific morphological features

(2018) Rebeca Manso et al.   Oncotarget

A Survey of Somatic Mutations in 41 Genes in a Cohort of T-Cell Lymphomas Identifies Frequent Mutations in Genes Involved in Epigenetic Modification

(2018) Sebastian Fernandez-Pol et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Identification of a functional antioxidant response element at the HIF1A locus

(2018) Sarah E. Lacher et al.   Redox Biology

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

(2018) Tenzin Gayden et al.   NATURE GENETICS

Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

(2018) Tenzin Gayden et al.   NATURE GENETICS

Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin

(2017) Maria Pamela Dobay et al.   HAEMATOLOGICA

Mycosis Fungoides and Sezary Syndrome

(2017) Francine M. Foss et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma

(2017) Salvia Jain et al.   MOLECULAR CANCER THERAPEUTICS

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas

(2017) Francesco Abate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

(2017) Jeremy A. Meier et al.   Science Signaling

Mitochondrial ROS control of cancer

(2017) María del Pilar Sosa Idelchik et al.   SEMINARS IN CANCER BIOLOGY

Identification of cell-type-specific mutations in nodal T-cell lymphomas

(2017) T B Nguyen et al.   Blood Cancer Journal

Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin

(2017) Maria Pamela Dobay et al.   HAEMATOLOGICA

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

(2017) Jeremy A. Meier et al.   Science Signaling

Angioimmunoblastic T-cell Lymphomas With the RHOA p.Gly17Val Mutation Have Classic Clinical and Pathologic Features

(2016) Sarah L. Ondrejka et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Pyrvinium selectively induces apoptosis of lymphoma cells through impairing mitochondrial functions and JAK2/STAT5

(2016) Meifang Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

No TP63 rearrangements in a selected group of primary cutaneous CD30 + lymphoproliferative disorders with aggressive clinical course

(2016) Anne M. R. Schrader et al.   BLOOD

Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas

(2016) D. Vallois et al.   BLOOD

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

(2016) S. H. Swerdlow et al.   BLOOD

Genomic signatures in T-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?

(2016) Javeed Iqbal et al.   BLOOD REVIEWS

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Mitochondrial ROS regulation of proliferating cells

(2016) Lauren Diebold et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma

(2016) H. Y. Yoo et al.   HAEMATOLOGICA

Roles of IDH1/2 and TET2 mutations in myeloid disorders

(2016) Satoshi Inoue et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

BCL6 locus is hypermethylated in angioimmunoblastic T-cell lymphoma

(2016) Shoko Nishizawa et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia

(2016) Saffet Ozturk et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Identification of Gene Mutations and Fusion Genes in Patients with Sézary Syndrome

(2016) Aparna Prasad et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

(2016) Keisuke Kataoka et al.   NATURE

PI-103 and Quercetin Attenuate PI3K-AKT Signaling Pathway in T- Cell Lymphoma Exposed to Hydrogen Peroxide

(2016) Akhilendra Kumar Maurya et al.   PLoS One

Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets

(2016) Ieva Saulite et al.   Biomed Research International

Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma

(2016) H. Y. Yoo et al.   HAEMATOLOGICA

Variegated RHOA mutations in adult T-cell leukemia/lymphoma

(2015) Y. Nagata et al.   BLOOD

Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides

(2015) L. Y. McGirt et al.   BLOOD

Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)

(2015) Rahul Checker et al.   CANCER LETTERS

ALK-positive (2p23 rearranged) anaplastic large cell lymphoma with localization to the skin in a pediatric patient

(2015) Melissa Pulitzer et al.   JOURNAL OF CUTANEOUS PATHOLOGY

MicroRNA Expression Profiling and DNA Methylation Signature for Deregulated MicroRNA in Cutaneous T-Cell Lymphoma

(2015) Juan Sandoval et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Recurrent activating mutations of CD28 in peripheral T-cell lymphomas

(2015) J Rohr et al.   LEUKEMIA

Genomic landscape of cutaneous T cell lymphoma

(2015) Jaehyuk Choi et al.   NATURE GENETICS

Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes

(2015) Linghua Wang et al.   NATURE GENETICS

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

Melanoma tumors frequently acquireLRP2/megalin expression, which modulates melanoma cell proliferation and survival rates

(2015) Rikke K. Andersen et al.   Pigment Cell & Melanoma Research

Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome

(2015) Mark J. Kiel et al.   Nature Communications

Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts

(2014) Sobia Iqbal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondria and redox homoeostasis as chemotherapeutic targets

(2014) Margaret M. Briehl et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes

(2014) E. R. Parrilla Castellar et al.   BLOOD

Deregulation in STAT signaling is important for cutaneous T-cell lymphoma (CTCL) pathogenesis and cancer progression

(2014) Elena Netchiporouk et al.   CELL CYCLE

Decitabine Induces Delayed Reactive Oxygen Species (ROS) Accumulation in Leukemia Cells and Induces the Expression of ROS Generating Enzymes

(2014) Tamer E. Fandy et al.   CLINICAL CANCER RESEARCH

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Immunological milieu in mycosis fungoides and Sézary syndrome

(2014) Tomomitsu Miyagaki et al.   JOURNAL OF DERMATOLOGY

Gain-of-functionCCR4mutations in adult T cell leukemia/lymphoma

(2014) Masao Nakagawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

(2014) Teresa Palomero et al.   NATURE GENETICS

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular characterization of subcutaneous panniculitis-like T-cell lymphoma reveals upregulation of immunosuppression- and autoimmunity-associated genes

(2014) Pilvi Maliniemi et al.   Orphanet Journal of Rare Diseases

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Association of Nerve Growth Factor, Chemokine (C-C motif) Ligands and Immunoglobulin E with Pruritus in Cutaneous T-cell Lymphoma

(2013) H Suga et al.   ACTA DERMATO-VENEREOLOGICA

Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation

(2013) Lulu Hu et al.   CELL

STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma

(2013) Katharina Kopp et al.   CELL CYCLE

The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies

(2013) Kristy Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Follicular lymphomatoid papulosis revisited: A study of 11 cases, with new histopathological findings

(2013) Werner Kempf et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Angiogenin levels are increased in lesional skin and sera in patients with erythrodermic cutaneous T cell lymphoma

(2012) Tomomitsu Miyagaki et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Retrospective analysis of prognostic factors for angioimmunoblastic T-cell lymphoma: a multicenter cooperative study in Japan

(2012) T. Tokunaga et al.   BLOOD

Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas

(2012) G. Vasmatzis et al.   BLOOD

Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9

(2012) M. K. Gleason et al.   BLOOD

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

(2012) F. Lemonnier et al.   BLOOD

Oxidative Stress Induced by Curcumin Promotes the Death of Cutaneous T-cell Lymphoma (HuT-78) by Disrupting the Function of Several Molecular Targets

(2012) M. A. Khan et al.   MOLECULAR CANCER THERAPEUTICS

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

TET2andDNMT3AMutations in Human T-Cell Lymphoma

(2012) Lucile Couronné et al.   NEW ENGLAND JOURNAL OF MEDICINE

The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications

(2011) E. Campo et al.   BLOOD

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

γ-Tocotrienol Induces Apoptosis in Human T Cell Lymphoma through Activation of Both Intrinsic and Extrinsic Pathways

(2011) Chandan Wilankar et al.   CURRENT PHARMACEUTICAL DESIGN

Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy

(2011) D. Sasaki et al.   HAEMATOLOGICA

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Tumor-Associated Macrophages in the Cutaneous SCC Microenvironment Are Heterogeneously Activated

(2011) Julia S. Pettersen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Anaplastic lymphoma kinase in human cancer

(2011) Antonella Barreca et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer

(2011) E. Tili et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myometrial Invasion and Lymph Node Metastasis in Endometrioid Carcinomas: Tumor-associated Macrophages, Microvessel Density, and HIF1A Have a Crucial Role

(2010) Inigo Espinosa et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Reduction of Fas/CD95 Promoter Methylation, Upregulation of Fas Protein, and Enhancement of Sensitivity to Apoptosis in Cutaneous T-Cell Lymphoma

(2010) Jianqiang Wu et al.   ARCHIVES OF DERMATOLOGY

Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing

(2010) A. L. Feldman et al.   BLOOD

The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease

(2010) C. Dierks et al.   CANCER RESEARCH

Ionizing Radiation Activates the Nrf2 Antioxidant Response

(2010) J. T. McDonald et al.   CANCER RESEARCH

H2O2-induced mitochondrial fragmentation in C2C12 myocytes

(2010) Xiying Fan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antigen Receptor Signaling to NF- B via CARMA1, BCL10, and MALT1

(2010) M. Thome et al.   Cold Spring Harbor Perspectives in Biology

Hydrogen Peroxide as a Cell-Survival Signaling Molecule

(2009) Gillian Groeger et al.   ANTIOXIDANTS & REDOX SIGNALING

Advances in the understanding and management of angioimmunoblastic T-cell lymphoma

(2009) Laurence de Leval et al.   BRITISH JOURNAL OF HAEMATOLOGY

Identification of Key Regions and Genes Important in the Pathogenesis of Sezary Syndrome by Combining Genomic and Expression Microarrays

(2009) E. Caprini et al.   CANCER RESEARCH

Macrophage Markers in Serum and Tumor Have Prognostic Impact in American Joint Committee on Cancer Stage I/II Melanoma

(2009) Trine O. Jensen et al.   JOURNAL OF CLINICAL ONCOLOGY

Cutaneous T-Cell Lymphoma: Roles for Chemokines and Chemokine Receptors

(2009) Xue-Song Wu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Oligonucleotide Array-CGH Identifies Genomic Subgroups and Prognostic Markers for Tumor Stage Mycosis Fungoides

(2009) Rocío Salgado et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IRF4 Gene Rearrangements Define a Subgroup of CD30-Positive Cutaneous T-Cell Lymphoma: A Study of 54 Cases

(2009) Anne Pham-Ledard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer

(2009) Hiroshi Kurahara et al.   JOURNAL OF SURGICAL RESEARCH

Embryonic stem cells use ZFP809 to silence retroviral DNAs

(2009) Daniel Wolf et al.   NATURE

The human GLUD2 glutamate dehydrogenase: Localization and functional aspects

(2009) Ioannis Zaganas et al.   NEUROCHEMISTRY INTERNATIONAL

Glutathionylation regulates IκB

(2008) In Sup Kil et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression

(2008) E. Contassot et al.   BLOOD

Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome

(2008) R. van Doorn et al.   BLOOD

Potential involvement of Notch1 signalling in the pathogenesis of primary cutaneous CD30-positive lymphoproliferative disorders

(2008) M.R. Kamstrup et al.   BRITISH JOURNAL OF DERMATOLOGY

Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome

(2008) M. H. Vermeer et al.   CANCER RESEARCH

Reactive Oxygen Species-Mediated Pancreatic β-Cell Death Is Regulated by Interactions between Stress-Activated Protein Kinases, p38 and c-Jun N-Terminal Kinase, and Mitogen-Activated Protein Kinase Phosphatases

(2008) Ni Hou et al.   ENDOCRINOLOGY

Low FAS/CD95 Expression by CTCL Correlates with Reduced Sensitivity to Apoptosis that Can Be Restored by FAS Upregulation

(2008) Jianqiang Wu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays

(2008) S-i Fujiwara et al.   LEUKEMIA

The Human Spindle Assembly Checkpoint Protein Bub3 Is Required for the Establishment of Efficient Kinetochore–Microtubule Attachments

(2008) Elsa Logarinho et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Fusion Is Increased by the Nuclear Coactivator PGC-1β

(2008) Marc Liesa et al.   PLoS One