Therapeutic potential of Short Chain Fatty acid production by gut microbiota in Neurodegenerative disorders

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

(2021) Alessio Vittorio Colombo et al.   eLife

Neuroprotective effects of short-chain fatty acids in MPTP induced mice model of Parkinson's disease

(2021) Yichao Hou et al.   EXPERIMENTAL GERONTOLOGY

Multiple roles of short-chain fatty acids in Alzheimer's disease

(2021) Hui Chen et al.   NUTRITION

Short-chain fatty acids as modulators of redox signaling in health and disease

(2021) Carmen González-Bosch et al.   Redox Biology

Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications

(2020) George Anderson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Targeting Myeloid-Specific Integrin α9β1 Improves Short and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis And Inflammation

(2020) Nirav Dhanesha et al.   CIRCULATION RESEARCH

Dysbiosis of Gut Microbiota and Short‐Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes

(2020) Chuhong Tan et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Gut mycobiome and its interaction with diet, gut bacteria and alzheimer's disease markers in subjects with mild cognitive impairment: A pilot study

(2020) Ravinder Nagpal et al.   EBioMedicine

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage

(2019) Hendrik Bartolomaeus et al.   CIRCULATION

Higher Risk of Stroke Is Correlated With Increased Opportunistic Pathogen Load and Reduced Levels of Butyrate-Producing Bacteria in the Gut

(2019) Xiuli Zeng et al.   Frontiers in Cellular and Infection Microbiology

Next generation probiotics in disease amelioration

(2019) Chih-Jung Chang et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

The Role of Gut Microbiota in Pathogenesis of Alzheimer's Disease

(2019) Mehmet Bostanciklioğlu   JOURNAL OF APPLIED MICROBIOLOGY

Gut microbiota in ALS: possible role in pathogenesis?

(2019) Pamela A. McCombe et al.   Expert Review of Neurotherapeutics

The Bidirectional Interactions between Resveratrol and Gut Microbiota: An Insight into Oxidative Stress and Inflammatory Bowel Disease Therapy

(2019) Yaolian Hu et al.   Biomed Research International

Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases

(2019) Sarah Hirschberg et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Gut Microbiota in Multiple Sclerosis: An Overview of Clinical Trials

(2019) Giovanni Schepici et al.   CELL TRANSPLANTATION

In vitro Characterization of Gut Microbiota-Derived Bacterial Strains With Neuroprotective Properties

(2019) Suaad Ahmed et al.   Frontiers in Cellular Neuroscience

Butyrate suppresses demyelination and enhances remyelination

(2019) Tong Chen et al.   Journal of Neuroinflammation

Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis

(2019) Qin Zeng et al.   NEUROCHEMISTRY INTERNATIONAL

Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota

(2019) Runzhi Chen et al.   PHARMACOLOGICAL RESEARCH

Sodium butyrate causes α-synuclein degradation by an Atg5-dependent and PI3K/Akt/mTOR-related autophagy pathway

(2019) Chen-Meng Qiao et al.   EXPERIMENTAL CELL RESEARCH

MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson’s disease

(2019) Shivani Ghaisas et al.   NEUROTOXICOLOGY

Combined therapies to treat complex diseases: The role of the gut microbiota in multiple sclerosis

(2018) Laura Calvo-Barreiro et al.   AUTOIMMUNITY REVIEWS

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson’s disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway

(2018) Meng-Fei Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease

(2018) Yiwei Qian et al.   BRAIN BEHAVIOR AND IMMUNITY

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

(2018) Kassem Makki et al.   Cell Host & Microbe

Vascular Cognitive Impairment and the Gut Microbiota

(2018) Sinian Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan

(2018) C. Bäuerl et al.   LETTERS IN APPLIED MICROBIOLOGY

Microbe-mitochondrion crosstalk and health: An emerging paradigm

(2018) Prashant Bajpai et al.   MITOCHONDRION

A controversy on the role of short-chain fatty acids in the pathogenesis of Parkinson's disease

(2018) Agata Mulak   MOVEMENT DISORDERS

The fecal microbiome of ALS patients

(2018) David Brenner et al.   NEUROBIOLOGY OF AGING

Oral administration of short chain fatty acids could attenuate fat deposition of pigs

(2018) A. R. Jiao et al.   PLoS One

Elevated Fecal pH Indicates a Profound Change in the Breastfed Infant Gut Microbiome Due to Reduction of Bifidobacterium over the Past Century

(2018) Bethany M. Henrick et al.   mSphere

Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy

(2018) Yanhai Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Crosstalk Between Gut Microbiota and the Central Nervous System: A Focus for Alzheimer's Disease

(2018) Vilma Maria Junges et al.   Current Alzheimer Research

Gut microbiota influences Alzheimer's disease pathogenesis by regulating acetate in Drosophila model

(2018) Yan Kong et al.   Future Microbiology

PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis

(2018) Kai Kaarniranta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cultivable butyrate-producing bacteria of elderly Japanese diagnosed with Alzheimer’s disease

(2018) Thi Thuy Tien Nguyen et al.   JOURNAL OF MICROBIOLOGY

Gut microbiota in patients with Parkinson's disease in southern China

(2018) Aiqun Lin et al.   PARKINSONISM & RELATED DISORDERS

Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

(2018) Vanessa de J.R. De-Paula et al.   PHARMACOLOGICAL RESEARCH

Propionate-producing bacteria in the intestine may associate with skewed responses of IL10-producing regulatory T cells in patients with relapsing polychondritis

(2018) Jun Shimizu et al.   PLoS One

Short-chain fatty acids and gut microbiota in multiple sclerosis

(2018) Pernille Melbye et al.   ACTA NEUROLOGICA SCANDINAVICA

Complementary functional strategy for modulation of human gut microbiota

(2018) Emanuel Vamanu   CURRENT PHARMACEUTICAL DESIGN

Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

(2017) Michael Doulberis et al.   HELICOBACTER

The nutrition-gut microbiome-physiology axis and allergic diseases

(2017) Craig McKenzie et al.   IMMUNOLOGICAL REVIEWS

The Gut Microbiota and Alzheimer’s Disease

(2017) Chunmei Jiang et al.   JOURNAL OF ALZHEIMERS DISEASE

Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis

(2017) Amber C. Chevalier et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

(2017) Erin M. Hill-Burns et al.   MOVEMENT DISORDERS

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

(2017) Anna Heintz-Buschart et al.   MOVEMENT DISORDERS

Beyond gut feelings: how the gut microbiota regulates blood pressure

(2017) Francine Z. Marques et al.   Nature Reviews Cardiology

Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study

(2017) Tomomi Minato et al.   PLoS One

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

(2017) Kerstin Berer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural changes of gut microbiota in Parkinson’s disease and its correlation with clinical features

(2017) Wei Li et al.   Science China-Life Sciences

The Crosstalk between the Gut Microbiota and Mitochondria during Exercise

(2017) Allison Clark et al.   Frontiers in Physiology

The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models

(2017) Miho Mizuno et al.   PLoS One

Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls

(2016) Helen Tremlett et al.   BMC Neurology

Gut microbiota in early pediatric multiple sclerosis: a case−control study

(2016) H. Tremlett et al.   EUROPEAN JOURNAL OF NEUROLOGY

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues

(2016) Kimberly A. Krautkramer et al.   MOLECULAR CELL

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

(2016) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Fatty acids and their therapeutic potential in neurological disorders

(2016) Enie Lei et al.   NEUROCHEMISTRY INTERNATIONAL

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

(2016) Francesca Pistollato et al.   NUTRITION REVIEWS

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

Alzheimer’s disease and gut microbiota

(2016) Xu Hu et al.   Science China-Life Sciences

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Evaluation of the Microbial Diversity in Amyotrophic Lateral Sclerosis Using High-Throughput Sequencing

(2016) Xin Fang et al.   Frontiers in Microbiology

Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions

(2015) Ashish Gurav et al.   BIOCHEMICAL JOURNAL

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome

(2015) Francesca De Filippis et al.   GUT

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Potential role of gut microbiota and tissue barriers in Parkinson's disease and amyotrophic lateral sclerosis

(2015) Xin Fang   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Gut Microbiota in Multiple Sclerosis

(2015) Brandi L. Cantarel et al.   JOURNAL OF INVESTIGATIVE MEDICINE

The identification of cognitive subtypes in Alzheimer's disease dementia using latent class analysis

(2015) Nienke M E Scheltens et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation

(2015) Mayu Kasubuchi et al.   Nutrients

De novo clustering methods outperform reference-based methods for assigning 16S rRNA gene sequences to operational taxonomic units

(2015) Sarah L. Westcott et al.   PeerJ

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s Disease

(2015) Satoru Hasegawa et al.   PLoS One

The effect of short-chain fatty acids on human monocyte-derived dendritic cells

(2015) Claudia Nastasi et al.   Scientific Reports

Gut Microbiome and Multiple Sclerosis

(2014) Pavan Bhargava et al.   Current Neurology and Neuroscience Reports

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Significantly higher frequency ofHelicobacter suisin patients with idiopathic parkinsonism than in control patients

(2013) C. Blaecher et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The biochemistry of the metabolic poison propionate 3-nitronate and its conjugate acid, 3-nitropropionate

(2013) Kevin Francis et al.   IUBMB LIFE

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Alzheimer's disease and the microbiome

(2013) Surjyadipta Bhattacharjee et al.   Frontiers in Cellular Neuroscience

Leptin regulates amyloid β production via the γ-secretase complex

(2012) Dana M. Niedowicz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

The role of gut microbiota in human obesity: Recent findings and future perspectives

(2012) A. Tagliabue et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Gut microbiota and diabetes: from pathogenesis to therapeutic perspective

(2011) Rémy Burcelin et al.   ACTA DIABETOLOGICA

Low Relative Abundances of the Mucolytic Bacterium Akkermansia muciniphila and Bifidobacterium spp. in Feces of Children with Autism

(2011) Lv Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Fecal Butyrate Levels Vary Widely among Individuals but Are Usually Increased by a Diet High in Resistant Starch

(2011) Alexandra L. McOrist et al.   JOURNAL OF NUTRITION

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

(2011) Marco A. R. Vinolo et al.   PLoS One

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

(2011) Roberto Berni Canani   WORLD JOURNAL OF GASTROENTEROLOGY

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

Valproic Acid is Neuroprotective in the Rotenone Rat Model of Parkinson’s Disease: Involvement of α-Synuclein

(2009) Barbara Monti et al.   NEUROTOXICITY RESEARCH

The MitoPark Mouse – An animal model of Parkinson's disease with impaired respiratory chain function in dopamine neurons

(2009) Mats I. Ekstrand et al.   PARKINSONISM & RELATED DISORDERS

The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases

(2009) Alex Iranzo et al.   SLEEP MEDICINE REVIEWS

Short-chain fatty acid signaling pathways in bovine mammary epithelial cells

(2008) Tomo Yonezawa et al.   REGULATORY PEPTIDES