Short LNA-modified oligonucleotide probes as efficient disruptors of DNA G-quadruplexes

G-quadruplexes: a promising target for cancer therapy

(2021) Nils Kosiol et al.   Molecular Cancer

Biological relevance and therapeutic potential of G-quadruplex structures in the human noncoding transcriptome

(2021) Martina Tassinari et al.   NUCLEIC ACIDS RESEARCH

Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues

(2021) Enrico Cadoni et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease

(2021) Roy Hanna et al.   Nature Communications

Identifying G-Quadruplex-DNA-Disrupting Small Molecules

(2021) Jérémie Mitteaux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA G-quadruplex structures: more than simple roadblocks to transcription?

(2021) Jenna Robinson et al.   NUCLEIC ACIDS RESEARCH

Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome

(2021) Sara Lago et al.   Nature Communications

Cockayne Syndrome B Protein Selectively Resolves and Interact with Intermolecular DNA G-Quadruplex Structures

(2021) Denise Liano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Duplex DNA Is Weakened in Nanoconfinement

(2020) Sagun Jonchhe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The regulation and functions of DNA and RNA G-quadruplexes

(2020) Dhaval Varshney et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-molecule visualization of DNA G-quadruplex formation in live cells

(2020) Marco Di Antonio et al.   Nature Chemistry

Ensemble Sensing Using Single-Molecule DNA Copolymers

(2020) Sagun Jonchhe et al.   ANALYTICAL CHEMISTRY

Whole genome experimental maps of DNA G-quadruplexes in multiple species

(2019) Giovanni Marsico et al.   NUCLEIC ACIDS RESEARCH

Submolecular dissection reveals strong and specific binding of polyamide–pyridostatin conjugates to human telomere interface

(2019) Shankar Mandal et al.   NUCLEIC ACIDS RESEARCH

G4Hunter web application: a web server for G-quadruplex prediction

(2019) Václav Brázda et al.   BIOINFORMATICS

Interplay of Three G-Quadruplex Units in the KIT Promoter

(2019) Cosimo Ducani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation

(2019) Guanhui Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locked nucleic acid: modality, diversity, and drug discovery

(2018) Peter H. Hagedorn et al.   DRUG DISCOVERY TODAY

Pif1 helicase unfolding of G-quadruplex DNA is highly dependent on sequence and reaction conditions

(2018) Alicia K. Byrd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

(2016) Jie Jiang et al.   NEURON

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA

(2016) Morten Scheibye-Knudsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Hybridization of G-Quadruplex-Forming Peptide Nucleic Acids to Guanine-Rich DNA Templates Inhibits DNA Polymerase η Extension

(2014) Connor T. Murphy et al.   BIOCHEMISTRY

Folding and Unfolding Pathways of the Human Telomeric G-Quadruplex

(2014) Robert D. Gray et al.   JOURNAL OF MOLECULAR BIOLOGY

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Structural and mechanical properties of individual human telomeric G-quadruplexes in molecularly crowded solutions

(2013) Soma Dhakal et al.   NUCLEIC ACIDS RESEARCH

The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells

(2012) Mark J. Morris et al.   NUCLEIC ACIDS RESEARCH

G4LDB: a database for discovering and studying G-quadruplex ligands

(2012) Qian Li et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation

(2012) D. Wei et al.   NUCLEIC ACIDS RESEARCH

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands

(2011) Deepak Koirala et al.   Nature Chemistry

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

(2010) Ellen Marie Straarup et al.   NUCLEIC ACIDS RESEARCH

A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expression

(2009) Zoë A. E. Waller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silencing c-MYCExpression by Targeting Quadruplex in P1 Promoter Using Locked Nucleic Acid Trap†

(2008) Niti Kumar et al.   BIOCHEMISTRY

An integrated laser-tweezers instrument for microanalysis of individual protein aggregates

(2007) Hanbin Mao et al.   SENSORS AND ACTUATORS B-CHEMICAL