Identifying G-Quadruplex-DNA-Disrupting Small Molecules

Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

(2020) Jose F Moruno-Manchon et al.   eLife

History of DNA Helicases

(2020) Robert M. Brosh et al.   Genes

The regulation and functions of DNA and RNA G-quadruplexes

(2020) Dhaval Varshney et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Landscape of G-quadruplex DNA structural regions in breast cancer

(2020) Robert Hänsel-Hertsch et al.   NATURE GENETICS

G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA

(2020) Eric A J Simko et al.   NUCLEIC ACIDS RESEARCH

Replication of G Quadruplex DNA

(2019) Leticia Koch Lerner et al.   Genes

Whole genome experimental maps of DNA G-quadruplexes in multiple species

(2019) Giovanni Marsico et al.   NUCLEIC ACIDS RESEARCH

Small-molecule affinity capture of DNA/RNA quadruplexes and their identification in vitro and in vivo through the G4RP protocol

(2019) Isaline Renard et al.   NUCLEIC ACIDS RESEARCH

Binding and Beyond: What Else Can G-Quadruplex Ligands Do?

(2019) Michael P. O'Hagan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications

(2019) Mubarak I. Umar et al.   MOLECULES

Modulation of DNA structure formation using small molecules

(2019) Imee M.A. del Mundo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanisms of DNA Replication and Repair: Insights from the Study of G-Quadruplexes

(2019) Tracy M. Bryan   MOLECULES

Structure and Function of Multimeric G-Quadruplexes

(2019) Sofia Kolesnikova et al.   MOLECULES

Identification of putative G-quadruplex DNA structures in S. pombe genome by quantitative PCR stop assay

(2019) Jan Jamroskovic et al.   DNA REPAIR

Helicases FANCJ, RTEL1 and BLM Act on Guanine Quadruplex DNA in Vivo

(2019) Peter Lansdorp et al.   Genes

Thermodynamic and spectroscopic investigations of TMPyP4 association with guanine- and cytosine-rich DNA and RNA repeats of C9orf72

(2018) Hasan Alniss et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ligand-Induced Dimerization of a Truncated Parallel MYC G-Quadruplex

(2018) Andrea Funke et al.   CHEMBIOCHEM

Up- and downregulation of mature miR-1587 function by modulating its G-quadruplex structure and using small molecules

(2018) Fangyuan Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Tetracationic and Tetraanionic Manganese Porphyrins: Electrochemical and Spectroelectrochemical Characterization

(2017) Xiaoqin Jiang et al.   INORGANIC CHEMISTRY

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

(2017) Robert Hänsel-Hertsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stabilization vs. destabilization of G-quadruplex superstructures: the role of the porphyrin derivative having spermine arms

(2017) A. D'Urso et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

G-Quadruplexes: Prediction, Characterization, and Biological Application

(2017) Chun Kit Kwok et al.   TRENDS IN BIOTECHNOLOGY

Interaction of metallacrown complexes with G-quadruplex DNA

(2016) Ewa Rajczak et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Quadruplex Nucleic Acids as Novel Therapeutic Targets

(2016) Stephen Neidle   JOURNAL OF MEDICINAL CHEMISTRY

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool

(2016) Pape Diaba Diabate et al.   NEW JOURNAL OF CHEMISTRY

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

Effects of trimethylamine N-oxide and urea on DNA duplex and G-quadruplex

(2016) Yu-mi Ueda et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Assessment of selectivity of G-quadruplex ligands via an optimised FRET melting assay

(2015) Aurore De Rache et al.   BIOCHIMIE

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

(2015) O. Mendoza et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Surface-promoted aggregation of amphiphilic quadruplex ligands drives their selectivity for alternative DNA structures

(2015) Aurélien Laguerre et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability

(2014) Guliang Wang et al.   DNA REPAIR

Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability

(2013) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMPyP4 Porphyrin Distorts RNA G-quadruplex Structures of the Disease-associated r(GGGGCC)nRepeat of theC9orf72Gene and Blocks Interaction of RNA-binding Proteins

(2013) Bita Zamiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental Methods for Studying the Interactions between G-Quadruplex Structures and Ligands

(2012) Joaquim Jaumot et al.   CURRENT PHARMACEUTICAL DESIGN

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

A Genomewide Screen for Suppressors of Alu-Mediated Rearrangements Reveals a Role for PIF1

(2012) Karen M. Chisholm et al.   PLoS One

Demonstration of Ligand Decoration, and Ligand-Induced Perturbation, of G-Quadruplexes in a Plasmid Using Atomic Force Microscopy

(2011) Ioanna Mela et al.   BIOCHEMISTRY

A stabilizing and denaturing dual-effect for natural polyamines interacting with G-quadruplexes depending on concentration

(2011) Hongxia Sun et al.   BIOCHIMIE

Induction of G-quadruplex DNA structure by Zn(II) 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin

(2011) Amlan J. Bhattacharjee et al.   BIOCHIMIE

A structural analysis of G-quadruplex/ligand interactions

(2011) Shozeb M. Haider et al.   BIOCHIMIE

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

Methods for investigating G-quadruplex DNA/ligand interactions

(2011) Pierre Murat et al.   CHEMICAL SOCIETY REVIEWS

Recognition of G-Quadruplex DNA by Triangular Star-Shaped Compounds: With or Without Side Chains?

(2011) Hélène Bertrand et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biochemical Characterization of Warsaw Breakage Syndrome Helicase

(2011) Yuliang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disordering of Human Telomeric G-Quadruplex with Novel Antiproliferative Anthrathiophenedione

(2011) Dmitry Kaluzhny et al.   PLoS One

Warsaw Breakage Syndrome, a Cohesinopathy Associated with Mutations in the XPD Helicase Family Member DDX11/ChlR1

(2010) Petra van der Lelij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SF1 and SF2 helicases: family matters

(2010) Margaret E Fairman-Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

5,10,15,20-Tetra-(N-methyl-3-pyridyl)porphyrin destabilizes the antiparallel telomeric quadruplex d(TTAGGG)4

(2010) Yu. V. Dutikova et al.   MOLECULAR BIOLOGY

Small-molecule-mediated G-quadruplex isolation from human cells

(2010) Sebastian Müller et al.   Nature Chemistry

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae

(2010) Aurèle Piazza et al.   NUCLEIC ACIDS RESEARCH

Macrocyclic DNA-Mismatch-Binding Ligands: Structural Determinants of Selectivity

(2009) Anton Granzhan et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expression

(2009) Zoë A. E. Waller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The quadruplex r(CGG)n destabilizing cationic porphyrin TMPyP4 cooperates with hnRNPs to increase the translation efficiency of fragile X premutation mRNA

(2009) N. Ofer et al.   NUCLEIC ACIDS RESEARCH

Peptide Nucleic Acid Containing a Meta-Substituted Phenylpyrrolocytosine Exhibits a Fluorescence Response and Increased Binding Affinity toward RNA

(2009) Filip Wojciechowski et al.   ORGANIC LETTERS

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

A Metal-Mediated Conformational Switch Controls G-Quadruplex Binding Affinity

(2008) David Monchaud et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Dynamics and Principal Components Analysis of Human Telomeric Quadruplex Multimers

(2008) Shozeb Haider et al.   BIOPHYSICAL JOURNAL

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluorescence and Hybridization Properties of Peptide Nucleic Acid Containing a Substituted Phenylpyrrolocytosine Designed to Engage Guanine with an Additional H-Bond

(2008) Filip Wojciechowski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres

(2008) Raphaël Rodriguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective recognition of pyrimidine–pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators

(2008) Matthias Bahr et al.   NUCLEIC ACIDS RESEARCH