Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells

(2022) Courtney E. Comar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

(2021) Goran Kokic et al.   Nature Communications

Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics

(2021) Monica C. Pillon et al.   Nature Communications

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

(2021) Angela Wahl et al.   NATURE

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

(2021) Youngchang Kim et al.   Communications Biology

Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading

(2021) Liming Yan et al.   CELL

An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15

(2021) Jason K. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of successive adenosine modifications by the conserved ribosomal methyltransferase KsgA

(2021) Niklas C Stephan et al.   NUCLEIC ACIDS RESEARCH

Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U

(2021) Meredith N Frazier et al.   NUCLEIC ACIDS RESEARCH

Duplex formation between the template and the nascent strand in the transcription-regulating sequences is associated with the site of template switching in SARS – CoV-2

(2021) Aaron R. D’Souza et al.   RNA Biology

Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome

(2021) Weifan Xu et al.   Cell Reports

Cellular origins of dsRNA, their recognition and consequences

(2021) Y. Grace Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design

(2021) Brandon Malone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages

(2020) Aaron Volk et al.   JOURNAL OF VIROLOGY

How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms

(2020) Meredith Corley et al.   MOLECULAR CELL

Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors

(2020) Matthew Hackbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV ‐2

(2020) Youngchang Kim et al.   PROTEIN SCIENCE

The molecular virology of Coronaviruses

(2020) Ella Hartenian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivating Three Interferon Antagonists Attenuates Pathogenesis of an Enteric Coronavirus

(2020) Xufang Deng et al.   JOURNAL OF VIROLOGY

Physiologic RNA Targets and Refined Sequence Specificity of Coronavirus EndoU

(2020) Rachel Ancar et al.   RNA

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

(2020) Liming Yan et al.   CELL

Coronavirus endoribonuclease activity in porcine epidemic diarrhea virus suppresses type I and type III interferon responses

(2019) Xufang Deng et al.   JOURNAL OF VIROLOGY

Double-Stranded RNA Sensors and Modulators in Innate Immunity

(2019) Sun Hur   Annual Review of Immunology

An “Old” protein with a new story: Coronavirus endoribonuclease is important for evading host antiviral defenses

(2018) Xufang Deng et al.   VIROLOGY

Homodimerisation-independent cleavage of dsRNA by a pestiviral nicking endoribonuclease

(2018) Carmela Lussi et al.   Scientific Reports

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

(2017) Xufang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Dicer uses distinct modules for recognizing dsRNA termini

(2017) Niladri K. Sinha et al.   SCIENCE

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins

(2017) Jeremiah Athmer et al.   mBio

Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy

(2016) J.M. de la Rosa-Trevín et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structural Biology of the Arterivirus nsp11 Endoribonucleases

(2016) Manfeng Zhang et al.   JOURNAL OF VIROLOGY

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

(2016) Melissa M Matthews et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6

(2016) Ole Niewoehner et al.   RNA

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

(2016) Melissa M Matthews et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Anomalous electrophoretic migration of short oligodeoxynucleotides labelled with 5′-terminal Cy5 dyes

(2014) Tom Killelea et al.   ELECTROPHORESIS

Mechanistic insights into editing-site specificity of ADARs

(2012) A. Kuttan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY