Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading
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Title
Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading
Authors
Keywords
SARS-CoV-2, replication-transcription complex, mRNA capping, proofreading, cryo-EM
Journal
CELL
Volume 184, Issue 13, Pages 3474-3485.e11
Publisher
Elsevier BV
Online
2021-05-25
DOI
10.1016/j.cell.2021.05.033
References
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- Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
- (2020) Aiping Wu et al. Cell Host & Microbe
- Structural basis for RNA replication by the SARS-CoV-2 polymerase
- (2020) Quan Wang et al. CELL
- Respiratory disease in rhesus macaques inoculated with SARS-CoV-2
- (2020) Vincent J. Munster et al. NATURE
- Structure of the RNA-dependent RNA polymerase from COVID-19 virus
- (2020) Yan Gao et al. SCIENCE
- An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- (2020) Timothy P. Sheahan et al. Science Translational Medicine
- Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex
- (2020) James Chen et al. CELL
- The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2
- (2020) Natacha S. Ogando et al. JOURNAL OF VIROLOGY
- Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis
- (2020) Liming Yan et al. CELL
- Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting
- (2020) Fran Robson et al. MOLECULAR CELL
- Architecture of a SARS-CoV-2 mini replication and transcription complex
- (2020) Liming Yan et al. Nature Communications
- The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity
- (2019) Natacha S. Ogando et al. Frontiers in Microbiology
- Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes
- (2019) Clemens Grimm et al. CELL
- New tools for the analysis and validation of cryo-EM maps and atomic models
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- Structural plasticity of D3–D14 ubiquitin ligase in strigolactone signalling
- (2018) Nitzan Shabek et al. NATURE
- A planarian nidovirus expands the limits of RNA genome size
- (2018) Amir Saberi et al. PLoS Pathogens
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Self-correcting mismatches during high-fidelity DNA replication
- (2017) Rafael Fernandez-Leiro et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA
- (2017) François Ferron et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Self-correcting mismatches during high-fidelity DNA replication
- (2017) Rafael Fernandez-Leiro et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mutagenesis ofS-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity
- (2016) James Brett Case et al. JOURNAL OF VIROLOGY
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex
- (2015) Yuanyuan Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities
- (2014) Lorenzo Subissi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy
- (2013) Shaoxia Chen et al. ULTRAMICROSCOPY
- RNA Polymerase Backtracking in Gene Regulation and Genome Instability
- (2012) Evgeny Nudler CELL
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex
- (2012) M. Bouvet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis of RNA polymerase II backtracking, arrest and reactivation
- (2011) Alan C. M. Cheung et al. NATURE
- Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases
- (2011) F.-F. Soon et al. SCIENCE
- Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex
- (2011) Yu Chen et al. PLoS Pathogens
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- 2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
- (2010) Stephane Daffis et al. NATURE
- In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation
- (2010) Mickaël Bouvet et al. PLoS Pathogens
- Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing
- (2010) Lance D. Eckerle et al. PLoS Pathogens
- Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase
- (2009) Y. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
- (2009) D. Wang et al. SCIENCE
- Coronavirus Nonstructural Protein 16 Is a Cap-0 Binding Enzyme Possessing (Nucleoside-2'O)-Methyltransferase Activity
- (2008) E. Decroly et al. JOURNAL OF VIROLOGY
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