Neural circuits regulating prosocial behaviors

Large-scale neural recordings call for new insights to link brain and behavior

(2022) Anne E. Urai et al.   NATURE NEUROSCIENCE

Hippocampal-amygdala memory circuits govern experience-dependent observational fear

(2022) Joseph I. Terranova et al.   NEURON

An Update on Psychopharmacological Treatment of Autism Spectrum Disorder

(2022) Ramkumar Aishworiya et al.   Neurotherapeutics

Can responsive deep brain stimulation be a cost‐effective treatment for severe obesity?

(2022) Uma V. Mahajan et al.   Obesity

Toward the explainability, transparency, and universality of machine learning for behavioral classification in neuroscience

(2022) Nastacia L. Goodwin et al.   CURRENT OPINION IN NEUROBIOLOGY

SLEAP: A deep learning system for multi-animal pose tracking

(2022) Talmo D. Pereira et al.   NATURE METHODS

Multi-animal pose estimation, identification and tracking with DeepLabCut

(2022) Jessy Lauer et al.   NATURE METHODS

Oxytocin neurons mediate the effect of social isolation via the VTA circuits

(2022) Stefano Musardo et al.   eLife

Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia

(2021) Monique L. Smith et al.   SCIENCE

Neural circuits of social behaviors: innate yet flexible

(2021) Dongyu Wei et al.   NEURON

Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System

(2021) Kate Z. Peters et al.   TRENDS IN NEUROSCIENCES

Oxytocin, Neural Plasticity, and Social Behavior

(2021) Robert C. Froemke et al.   Annual Review of Neuroscience

An amygdala-to-hypothalamus circuit for social reward

(2021) Rongfeng K. Hu et al.   NATURE NEUROSCIENCE

Affective empathy and prosocial behavior in rodents

(2021) Seong-Wook Kim et al.   CURRENT OPINION IN NEUROBIOLOGY

Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time

(2021) Daniel K. Lee et al.   NATURE NEUROSCIENCE

Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD

(2021) Jessica J. Walsh et al.   NEUROPSYCHOPHARMACOLOGY

Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin

(2021) Daniel J. Christoffel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5-HT modulation of a medial septal circuit tunes social memory stability

(2021) Xiaoting Wu et al.   NATURE

VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error

(2021) Clément Solié et al.   NATURE NEUROSCIENCE

Refining oxytocin therapy for autism: context is key

(2021) Charles L. Ford et al.   Nature Reviews Neurology

The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

(2021) Cristina Segalin et al.   eLife

An operant social self-administration and choice model in rats

(2020) Marco Venniro et al.   Nature Protocols

The contagion of social defeat stress: Insights from rodent studies

(2020) Luca Carnevali et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neonatal CSF vasopressin concentration predicts later medical record diagnoses of autism spectrum disorder

(2020) Ozge Oztan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

16p11 Duplication Disrupts Hippocampal-Orbitofrontal-Amygdala Connectivity, Revealing a Neural Circuit Endophenotype for Schizophrenia

(2020) Greg C. Bristow et al.   Cell Reports

Reward Contributions to Serotonergic Functions

(2020) Zhixiang Liu et al.   Annual Review of Neuroscience

Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors

(2020) Sergey Anpilov et al.   NEURON

Better living through chemistry: MDMA’s prosocial mechanism as a starting point for improved therapeutics

(2020) Boris D. Heifets et al.   NEUROPSYCHOPHARMACOLOGY

A social encounter drives gene expression changes linked to neuronal function, brain development, and related disorders in mice expressing the serotonin transporter Ala56 variant

(2020) Kally C. O’Reilly et al.   NEUROSCIENCE LETTERS

Rage Against the Machine: Advancing the study of aggression ethology via machine learning.

(2020) Nastacia L. Goodwin et al.   PSYCHOPHARMACOLOGY

Neuromodulation Special IssueNon-invasive stimulation of the social brain: the methodological challenges

(2020) Tegan Penton et al.   Social Cognitive and Affective Neuroscience

Hippocampal CA2 sharp-wave ripples reactivate and promote social memory

(2020) Azahara Oliva et al.   NATURE

A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice

(2020) Kazuhiko Yamamuro et al.   NATURE NEUROSCIENCE

Revealing the structure of pharmacobehavioral space through motion sequencing

(2020) Alexander B. Wiltschko et al.   NATURE NEUROSCIENCE

Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model

(2020) Macayla L. Donegan et al.   NATURE NEUROSCIENCE

Imaging Neurotransmitter and Neuromodulator Dynamics In Vivo with Genetically Encoded Indicators

(2020) Bernardo L. Sabatini et al.   NEURON

A Primer on Motion Capture with Deep Learning: Principles, Pitfalls, and Perspectives

(2020) Alexander Mathis et al.   NEURON

Towards a unified theory of emotional contagion in rodents—A meta-analysis

(2020) Julen Hernandez-Lallement et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

From Multisensory Assessment to Functional Interpretation of Social Behavioral Phenotype in Transgenic Mouse Models for Autism Spectrum Disorders

(2020) Hiroyuki Arakawa   Frontiers in Psychiatry

HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors

(2019) Jia Cheng et al.   NEURON

Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models

(2019) Michelle W. Antoine et al.   NEURON

The molecular and cellular mechanisms of depression: a focus on reward circuitry

(2019) Megan E. Fox et al.   MOLECULAR PSYCHIATRY

Oxytocin-dependent reopening of a social reward learning critical period with MDMA

(2019) Romain Nardou et al.   NATURE

Embracing diversity in the 5-HT neuronal system

(2019) Benjamin W. Okaty et al.   NATURE REVIEWS NEUROSCIENCE

Behavioral neuroscience of autism

(2019) Toru Takumi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism

(2019) Karen J. Parker et al.   Science Translational Medicine

Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism

(2019) Maria T. Lazaro et al.   Cell Reports

Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

(2019) Mary L Phillips et al.   eLife

Operant Social Reward Decreases Incubation of Heroin Craving in Male and Female Rats

(2019) Marco Venniro et al.   BIOLOGICAL PSYCHIATRY

Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression

(2019) Ja Wook Koo et al.   BIOLOGICAL PSYCHIATRY

Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice

(2019) Valentina Ferretti et al.   CURRENT BIOLOGY

Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice

(2019) Baolin Guo et al.   NATURE NEUROSCIENCE

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability

(2019) Kristina Valentinova et al.   NATURE NEUROSCIENCE

Helping-Like Behaviour in Mice Towards Conspecifics Constrained Inside Tubes

(2019) Hiroshi Ueno et al.   Scientific Reports

DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning

(2019) Jacob M Graving et al.   eLife

Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory

(2019) Soledad Domínguez et al.   Cell Reports

Deep learning tools for the measurement of animal behavior in neuroscience

(2019) Mackenzie Weygandt Mathis et al.   CURRENT OPINION IN NEUROBIOLOGY

An endocannabinoid-regulated basolateral amygdala–nucleus accumbens circuit modulates sociability

(2019) Oakleigh M. Folkes et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC

(2019) Qian Li et al.   NEUROPHARMACOLOGY

Distinct neural mechanisms for the prosocial and rewarding properties of MDMA

(2019) Boris D. Heifets et al.   Science Translational Medicine

Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability

(2018) Rainbo Hultman et al.   CELL

Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning

(2018) Stephen A. Allsop et al.   CELL

Neural control of parental behaviors

(2018) Johannes Kohl et al.   CURRENT OPINION IN NEUROBIOLOGY

Insular cortex mediates approach and avoidance responses to social affective stimuli

(2018) Morgan M. Rogers-Carter et al.   NATURE NEUROSCIENCE

Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction

(2018) Sora Shin et al.   NEURON

Neural Circuit Mechanisms of Social Behavior

(2018) Patrick Chen et al.   NEURON

5-HT release in nucleus accumbens rescues social deficits in mouse autism model

(2018) Jessica J. Walsh et al.   NATURE

Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study

(2018) Alicia L. Danforth et al.   PSYCHOPHARMACOLOGY

Volitional social interaction prevents drug addiction in rat models

(2018) Marco Venniro et al.   NATURE NEUROSCIENCE

Oxytocin Transforms Firing Mode of CA2 Hippocampal Neurons

(2018) Natasha N. Tirko et al.   NEURON

A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics

(2018) Torcato Meira et al.   Nature Communications

Is Empathy for Pain Unique in Its Neural Correlates? A Meta-Analysis of Neuroimaging Studies of Empathy

(2018) Inge Timmers et al.   Frontiers in Behavioral Neuroscience

Arbaclofen in fragile X syndrome: results of phase 3 trials

(2017) Elizabeth Berry-Kravis et al.   Journal of Neurodevelopmental Disorders

Conditional Deletion of Hippocampal CA2/CA3a Oxytocin Receptors Impairs the Persistence of Long-Term Social Recognition Memory in Mice

(2017) Yu-Ting Lin et al.   JOURNAL OF NEUROSCIENCE

An intra-amygdala circuit specifically regulates social fear learning

(2017) Robert C Twining et al.   NATURE NEUROSCIENCE

Prefrontal cortical control of a brainstem social behavior circuit

(2017) Tamara B Franklin et al.   NATURE NEUROSCIENCE

Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory

(2017) Felix Leroy et al.   NEURON

Biased Oxytocinergic Modulation of Midbrain Dopamine Systems

(2017) Lei Xiao et al.   NEURON

R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice

(2017) Laura J Stoppel et al.   NEUROPSYCHOPHARMACOLOGY

Closing the loop on impulsivity via nucleus accumbens delta-band activity in mice and man

(2017) Hemmings Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism

(2017) Karen J. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gating of social reward by oxytocin in the ventral tegmental area

(2017) Lin W. Hung et al.   SCIENCE

Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2

(2017) Catherine J. Peña et al.   SCIENCE

Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2 -deficient mice

(2017) Aslihan Selimbeyoglu et al.   Science Translational Medicine

Social Fear Learning: from Animal Models to Human Function

(2017) Jacek Debiec et al.   TRENDS IN COGNITIVE SCIENCES

Hippocampal oxytocin receptors are necessary for discrimination of social stimuli

(2017) Tara Raam et al.   Nature Communications

Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

(2017) Nobuhiro Nakai et al.   Science Advances

Comparison of chronic physical and emotional social defeat stress effects on mesocorticolimbic circuit activation and voluntary consumption of morphine

(2017) S. E. Cooper et al.   Scientific Reports

Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol

(2016) Jérôme A.J. Becker et al.   ADDICTION BIOLOGY

MDMA as a Probe and Treatment for Social Behaviors

(2016) Boris D. Heifets et al.   CELL

Communication in Neural Circuits: Tools, Opportunities, and Challenges

(2016) Talia N. Lerner et al.   CELL

Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation

(2016) Gillian A. Matthews et al.   CELL

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

(2016) Kun Li et al.   CELL

Targeted activation of the hippocampal CA2 area strongly enhances social memory

(2016) A S Smith et al.   MOLECULAR PSYCHIATRY

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

(2016) Christian R Marshall et al.   NATURE GENETICS

Circuit modules linking internal states and social behaviour in flies and mice

(2016) David J. Anderson   NATURE REVIEWS NEUROSCIENCE

Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome

(2016) Rebecca A. Piskorowski et al.   NEURON

Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex

(2016) A.C. Felix-Ortiz et al.   NEUROSCIENCE

The serotonin system in autism spectrum disorder: From biomarker to animal models

(2016) C.L. Muller et al.   NEUROSCIENCE

Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions

(2016) Zhimin Song et al.   PSYCHONEUROENDOCRINOLOGY

Ventral CA1 neurons store social memory

(2016) T. Okuyama et al.   SCIENCE

Oxytocin-dependent consolation behavior in rodents

(2016) J. P. Burkett et al.   SCIENCE

Social and novel contexts modify hippocampal CA2 representations of space

(2016) Georgia M. Alexander et al.   Nature Communications

Social transfer of pain in mice

(2016) M. L. Smith et al.   Science Advances

Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood

(2015) Vera Niederkofler et al.   ACS Chemical Neuroscience

Mice undergoing neuropathic pain induce anxiogenic-like effects and hypernociception in cagemates

(2015) Daniela Baptista-de-Souza et al.   BEHAVIOURAL PHARMACOLOGY

Illuminating circuitry relevant to psychiatric disorders with optogenetics

(2015) Elizabeth E Steinberg et al.   CURRENT OPINION IN NEUROBIOLOGY

Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress

(2015) Daniel J Christoffel et al.   NATURE NEUROSCIENCE

The prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled studies in humans and laboratory animals

(2015) Philip Kamilar-Britt et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Promoting social plasticity in developmental disorders with non-invasive brain stimulation techniques

(2015) Paulo S. Boggio et al.   Frontiers in Neuroscience

22q11.2 deletion syndrome

(2015) Donna M. McDonald-McGinn et al.   Nature Reviews Disease Primers

Oxytocin Modulates Female Sociosexual Behavior through a Specific Class of Prefrontal Cortical Interneurons

(2014) Miho Nakajima et al.   CELL

Natural Neural Projection Dynamics Underlying Social Behavior

(2014) Lisa A. Gunaydin et al.   CELL

A Framework for Studying Emotions across Species

(2014) David J. Anderson et al.   CELL

Altered Gene Expression and Spine Density in Nucleus Accumbens of Adolescent and Adult Male Mice Exposed to Emotional and Physical Stress

(2014) Brandon L. Warren et al.   DEVELOPMENTAL NEUROSCIENCE

Lesions to the CA2 region of the hippocampus impair social memory in mice

(2014) Erica L. Stevenson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Amygdala Inputs to the Ventral Hippocampus Bidirectionally Modulate Social Behavior

(2014) A. C. Felix-Ortiz et al.   JOURNAL OF NEUROSCIENCE

Oxytocin Reverses Amphetamine-Induced Deficits in Social Bonding: Evidence for an Interaction with Nucleus Accumbens Dopamine

(2014) K. A. Young et al.   JOURNAL OF NEUROSCIENCE

The hippocampal CA2 region is essential for social memory

(2014) Frederick L. Hitti et al.   NATURE

Social interaction with a cagemate in pain facilitates subsequent spinal nociception via activation of the medial prefrontal cortex in rats

(2014) Zhen Li et al.   PAIN

The Penetrance of Copy Number Variations for Schizophrenia and Developmental Delay

(2013) George Kirov et al.   BIOLOGICAL PSYCHIATRY

Role of the hippocampus and orbitofrontal cortex during the disambiguation of social cues in working memory

(2013) Robert S. Ross et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Social and emotional neuroscience

(2013) Ralph Adolphs et al.   CURRENT OPINION IN NEUROBIOLOGY

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

(2013) Gül Dölen et al.   NATURE

A causal link between prediction errors, dopamine neurons and learning

(2013) Elizabeth E Steinberg et al.   NATURE NEUROSCIENCE

Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

(2013) Jessica J Walsh et al.   NATURE NEUROSCIENCE

The brain reward circuitry in mood disorders

(2013) Scott J. Russo et al.   NATURE REVIEWS NEUROSCIENCE

BLA to vHPC Inputs Modulate Anxiety-Related Behaviors

(2013) Ada C. Felix-Ortiz et al.   NEURON

Reward and aversion in a heterogeneous midbrain dopamine system

(2013) Stephan Lammel et al.   NEUROPHARMACOLOGY

Neurobiological Sequelae of Witnessing Stressful Events in Adult Mice

(2012) Brandon L. Warren et al.   BIOLOGICAL PSYCHIATRY

CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics

(2012) Dheeraj Malhotra et al.   CELL

Dopamine neurons modulate neural encoding and expression of depression-related behaviour

(2012) Kay M. Tye et al.   NATURE

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

Dopaminergic Modulation of Synaptic Transmission in Cortex and Striatum

(2012) Nicolas X. Tritsch et al.   NEURON

Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior

(2012) J. Veenstra-VanderWeele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics

(2012) Michael Lukas et al.   PSYCHONEUROENDOCRINOLOGY

Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABAB Receptors with Arbaclofen

(2012) C. Henderson et al.   Science Translational Medicine

What is an animal emotion?

(2011) Frans B.M. de Waal   Annals of the New York Academy of Sciences

A case study in behavioral analysis, synthesis and attention to detail: Social learning of food preferences

(2011) Bennett G. Galef   BEHAVIOURAL BRAIN RESEARCH

Serotonin Induces Long-Term Depression at Corticostriatal Synapses

(2011) B. N. Mathur et al.   JOURNAL OF NEUROSCIENCE

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

Rodent empathy and affective neuroscience

(2011) Jules B. Panksepp et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The reciprocal interaction between serotonin and social behaviour

(2011) Dominik Kiser et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Structural and synaptic plasticity in stress-related disorders

(2011) Daniel J. Christoffel et al.   REVIEWS IN THE NEUROSCIENCES

Impaired Emotional-Like Behavior and Serotonergic Function During Protracted Abstinence from Chronic Morphine

(2010) Celia Goeldner et al.   BIOLOGICAL PSYCHIATRY

Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC

(2010) Daejong Jeon et al.   NATURE NEUROSCIENCE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Lack of Efficacy of Citalopram in Children With Autism Spectrum Disorders and High Levels of Repetitive Behavior

(2009) Bryan H. King et al.   ARCHIVES OF GENERAL PSYCHIATRY

Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration

(2009) Michael J Higley et al.   NATURE NEUROSCIENCE

Strong association of de novo copy number mutations with sporadic schizophrenia

(2008) Bin Xu et al.   NATURE GENETICS

Putting the Altruism Back into Altruism: The Evolution of Empathy

(2007) Frans B.M. de Waal   Annual Review of Psychology