Functional Bacterial Amyloids: Understanding Fibrillation, Regulating Biofilm Fibril Formation and Organizing Surface Assemblies

Toward a life cycle inventory for graphite production

(2022) Daria Surovtseva et al.   JOURNAL OF INDUSTRIAL ECOLOGY

Chemico-biological aspects of (−)-epigallocatechin-3-gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future prospects

(2022) Revathy Sahadevan et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

(2022) Nikolaos Louros et al.   Nature Communications

Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide

(2022) Kumju Youn et al.   Food Science and Human Wellness

A multimethod approach for analyzing FapC fibrillation and determining mass per length

(2021) Helena Østergaard Rasmussen et al.   BIOPHYSICAL JOURNAL

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Frustrated peptide chains at the fibril tip control the kinetics of growth of amyloid-β fibrils

(2021) Yuechuan Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Green Tea Polyphenol Epigallocatechin-Gallate in Amyloid Aggregation and Neurodegenerative Diseases

(2021) Luiza Fernandes et al.   Frontiers in Neuroscience

Folding Steps in the Fibrillation of Functional Amyloid: Denaturant Sensitivity Reveals Common Features in Nucleation and Elongation

(2021) Thorbjørn V. Sønderby et al.   JOURNAL OF MOLECULAR BIOLOGY

AlphaFold and the amyloid landscape

(2021) Francisca Pinheiro et al.   JOURNAL OF MOLECULAR BIOLOGY

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation

(2021) Madhu Nagaraj et al.   Chemical Science

NMR insights into the pre-amyloid ensemble and secretion targeting of the curli subunit CsgA

(2020) Lee Sewell et al.   Scientific Reports

Conformable self-assembling amyloid protein coatings with genetically programmable functionality

(2020) Yingfeng Li et al.   Science Advances

Quantitating denaturation by formic acid: Imperfect repeats are essential to the stability of the functional amyloid protein FapC

(2020) Line Friis Bakmann Christensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

(2020) Nikolaos Louros et al.   Nature Communications

Green Tea Polyphenol Microparticles Based on the Oxidative Coupling of EGCG Inhibit Amyloid Aggregation/Cytotoxicity and Serve as a Platform for Drug Delivery

(2020) Luiza Fernandes et al.   ACS Biomaterials-Science & Engineering

Inhibitors of α-Synuclein Fibrillation and Oligomer Toxicity in Rosa damascena: The All-Pervading Powers of Flavonoids and Phenolic Glycosides

(2020) Hoda Eskandari et al.   ACS Chemical Neuroscience

Common plant flavonoids prevent the assembly of amyloid curli fibres and can interfere with bacterial biofilm formation

(2020) Mihaela Pruteanu et al.   ENVIRONMENTAL MICROBIOLOGY

Multiple Protective Roles of Nanoliposome‐Incorporated Baicalein against Alpha‐Synuclein Aggregates

(2020) Farhang Aliakbari et al.   ADVANCED FUNCTIONAL MATERIALS

Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity

(2019) Hossein Mohammad-Beigi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical Determinants of Amyloid Assembly in Biofilm Formation

(2019) Maria Andreasen et al.   mBio

Dimerization energetics of curli fiber subunits CsgA and CsgB

(2019) Martha Dunbar et al.   npj Computational Materials

A Possible Connection Between Plant Longevity and the Absence of Protein Fibrillation: Basis for Identifying Aggregation Inhibitors in Plants

(2019) Hossein Mohammad-Beigi et al.   Frontiers in Plant Science

Inhibition of amyloid fibrillation by small molecules and nanomaterials: Strategic development of pharmaceuticals against amyloidosis

(2019) Vandna Sharma et al.   PROTEIN AND PEPTIDE LETTERS

Tafamidis: A Review in Transthyretin Amyloidosis with Polyneuropathy

(2019) Yvette N. Lamb et al.   DRUGS

Targeting Bacterial Biofilms by the Green Tea Polyphenol EGCG

(2019) Regine Hengge   MOLECULES

Genetically Programmable Self‐Regenerating Bacterial Hydrogels

(2019) Anna M. Duraj‐Thatte et al.   ADVANCED MATERIALS

Patterned Amyloid Materials Integrating Robustness and Genetically Programmable Functionality

(2019) Yingfeng Li et al.   NANO LETTERS

WALTZ-DB 2.0: an updated database containing structural information of experimentally determined amyloid-forming peptides

(2019) Nikolaos Louros et al.   NUCLEIC ACIDS RESEARCH

Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents

(2019) Sergei Perov et al.   PLoS Pathogens

The structure of bactofilin filaments reveals their mode of membrane binding and lack of polarity

(2019) Xian Deng et al.   Nature Microbiology

Peptide-Based Molecular Strategies To Interfere with Protein Misfolding, Aggregation, and Cell Degeneration

(2019) Valentina Armiento et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bacterial amphiphiles as amyloid inducers: Effect of Rhamnolipid and Lipopolysaccharide on FapC fibrillation

(2019) Zahra Najarzadeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Biomolecular Material Recognition in Two Dimensions: Peptide Binding to Graphene, h-BN, and MoS2 Nanosheets as Unique Bioconjugates

(2019) Tiffany R. Walsh et al.   BIOCONJUGATE CHEMISTRY

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers

(2019) Zahra Najarzadeh et al.   Biomolecules

Amyloid structures: much more than just a cross-β fold

(2019) Rodrigo Gallardo et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Universal and Ultrastable Mineralization Coating Bioinspired from Biofilms

(2018) Xiao Yang et al.   ADVANCED FUNCTIONAL MATERIALS

Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms

(2018) Alissa Bleem et al.   JOURNAL OF MOLECULAR BIOLOGY

Ecology and Biogenesis of Functional Amyloids in Pseudomonas

(2018) Sarah L. Rouse et al.   JOURNAL OF MOLECULAR BIOLOGY

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

(2018) Ladan Khodaparast et al.   Nature Communications

Inhibitory effects of Myricetin derivatives on curli-dependent biofilm formation in Escherichia coli

(2018) Ken-ichi Arita-Morioka et al.   Scientific Reports

Imperfect repeats in the functional amyloid protein FapC reduce the tendency to fragment during fibrillation

(2018) Casper B. Rasmussen et al.   PROTEIN SCIENCE

Understanding curli amyloid-protein aggregation by hydrogen–deuterium exchange and mass spectrometry

(2017) Hanliu Wang et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Nucleation and growth of a bacterial functional amyloid at single-fiber resolution

(2017) Mike Sleutel et al.   Nature Chemical Biology

A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis

(2017) Sarah L. Rouse et al.   Nature Communications

Attenuation of β-Amyloid Toxicity In Vitro and In Vivo by Accelerated Aggregation

(2017) Aihua Yang et al.   Neuroscience Bulletin

Structural predictions for curli amyloid fibril subunits CsgA and CsgB

(2017) E. P. DeBenedictis et al.   RSC Advances

Epigallocatechin Gallate Remodels Fibrils of Lattice Corneal Dystrophy Protein, Facilitating Proteolytic Degradation and Preventing Formation of Membrane-Permeabilizing Species

(2016) Marcel Stenvang et al.   BIOCHEMISTRY

Epigallocatechin Gallate Remodels Overexpressed Functional Amyloids inPseudomonas aeruginosaand Increases Biofilm Susceptibility to Antibiotic Treatment

(2016) Marcel Stenvang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intrinsic aggregation propensity of the CsgB nucleator protein is crucial for curli fiber formation

(2016) Nikolaos N. Louros et al.   JOURNAL OF STRUCTURAL BIOLOGY

The green tea polyphenol EGCG inhibitsE. colibiofilm formation by impairing amyloid curli fibre assembly and downregulating the biofilm regulator CsgD via the σE-dependent sRNA RybB

(2016) Diego O. Serra et al.   MOLECULAR MICROBIOLOGY

A Monte Carlo Study of the Early Steps of Functional Amyloid Formation

(2016) Pengfei Tian et al.   PLoS One

Gallic acid loaded onto polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA-GA NPs) stabilizes α-synuclein in the unfolded conformation and inhibits aggregation

(2016) Hossein Mohammad-Beigi et al.   RSC Advances

Scalable Production of Genetically Engineered Nanofibrous Macroscopic Materials via Filtration

(2016) Noémie-Manuelle Dorval Courchesne et al.   ACS Biomaterials-Science & Engineering

Scalable Production of Genetically Engineered Nanofibrous Macroscopic Materials via Filtration

(2016) Noémie-Manuelle Dorval Courchesne et al.   ACS Biomaterials Science & Engineering

Adhesion mechanisms of curli subunit CsgA to abiotic surfaces

(2016) E. P. DeBenedictis et al.   Science Advances

Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

(2016) Jonathan D. Taylor et al.   Scientific Reports

Toxic species in amyloid disorders: Oligomers or mature fibrils

(2015) Vibha Taneja et al.   Annals of Indian Academy of Neurology

Protein functionalized carbon nanomaterials for biomedical applications

(2015) Sabrina F. Oliveira et al.   CARBON

Inhibition of protein aggregation and amyloid formation by small molecules

(2015) Andrew J Doig et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation

(2015) Margery L. Evans et al.   MOLECULAR CELL

Protein aggregation as an antibiotic design strategy

(2015) Natalia G. Bednarska et al.   MOLECULAR MICROBIOLOGY

In vitro fibrillization of Alzheimer’s amyloid-β peptide (1-42)

(2015) Ann Tiiman et al.   AIP Advances

Functional bacterial amyloid increases Pseudomonas biofilm hydrophobicity and stiffness

(2015) Guanghong Zeng et al.   Frontiers in Microbiology

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts

(2015) Erik Chorell et al.   PLoS One

Structure of a Functional Amyloid Protein Subunit Computed Using Sequence Variation

(2014) Pengfei Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Secretion and functional display of fusion proteins through the curli biogenesis pathway

(2014) Nani Van Gerven et al.   MOLECULAR MICROBIOLOGY

Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG

(2014) Parveen Goyal et al.   NATURE

Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

(2014) Lydia M. Young et al.   Nature Chemistry

Strong underwater adhesives made by self-assembling multi-protein nanofibres

(2014) Chao Zhong et al.   Nature Nanotechnology

Programmable biofilm-based materials from engineered curli nanofibres

(2014) Peter Q. Nguyen et al.   Nature Communications

The antimicrobial possibilities of green tea

(2014) Wanda C. Reygaert   Frontiers in Microbiology

Cosolvent Effects on Protein Stability

(2013) Deepak R. Canchi et al.   Annual Review of Physical Chemistry

Inherent Relationships among Different Biophysical Prediction Methods for Intrinsically Disordered Proteins

(2013) Fan Jin et al.   BIOPHYSICAL JOURNAL

Aggregation Prone Regions and Gatekeeping Residues in Protein Sequences

(2013) Jacinte Beerten et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The interplay between carbon nanomaterials and amyloid fibrils in bio-nanotechnology

(2013) Chaoxu Li et al.   Nanoscale

Evolutionary Insight into the Functional Amyloids of the Pseudomonads

(2013) Morten S. Dueholm et al.   PLoS One

Antibacterial surfaces: the quest for a new generation of biomaterials

(2013) Jafar Hasan et al.   TRENDS IN BIOTECHNOLOGY

Expression of Fap amyloids inPseudomonas aeruginosa,P. fluorescens,andP. putidaresults in aggregation and increased biofilm formation

(2013) Morten S. Dueholm et al.   MicrobiologyOpen

Controlling Self-Assembly of Engineered Peptides on Graphite by Rational Mutation

(2012) Christopher R. So et al.   ACS Nano

The effect of graphene oxide on conformation change, aggregation and cytotoxicity of HIV-1 regulatory protein (Vpr)

(2012) Min Zhang et al.   BIOMATERIALS

On the Possible Amyloid Origin of Protein Folds

(2012) Jason Greenwald et al.   JOURNAL OF MOLECULAR BIOLOGY

Curli Functional Amyloid Systems Are Phylogenetically Widespread and Display Large Diversity in Operon and Protein Structure

(2012) Morten S. Dueholm et al.   PLoS One

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Amyloids Composed of Phenol Soluble Modulins Stabilize Staphylococcus aureus Biofilms

(2012) Kelly Schwartz et al.   PLoS Pathogens

Observation of Reduced Cytotoxicity of Aggregated Amyloidogenic Peptides with Chaperone-like Molecules

(2011) Lei Liu et al.   ACS Nano

Fibrillation of the Major Curli Subunit CsgA under a Wide Range of Conditions Implies a Robust Design of Aggregation

(2011) Morten S. Dueholm et al.   BIOCHEMISTRY

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

(2011) Derliz Mereles et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

(2011) Andrew J. Baldwin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CsgE is a curli secretion specificity factor that prevents amyloid fibre aggregation

(2011) Ashley A. Nenninger et al.   MOLECULAR MICROBIOLOGY

Nanomechanics of functional and pathological amyloid materials

(2011) Tuomas P. J. Knowles et al.   Nature Nanotechnology

Self-assembly of human amylin-derived peptides studied by atomic force microscopy and single molecule force spectroscopy

(2011) Juan José Valle-Delgado et al.   Soft Matter

Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner

(2010) Nagababu Chinnam et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Functional amyloid in Pseudomonas

(2010) Morten S. Dueholm et al.   MOLECULAR MICROBIOLOGY

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Functional Curli Amyloid Is Not Based on In-register Parallel β-Sheet Structure

(2009) Frank Shewmaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Common Architecture of Cross-β Amyloid

(2009) Thomas R. Jahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural characteristics of the beta-sheet-like human and rat islet amyloid polypeptides as determined by scanning tunneling microscopy

(2009) Xiaobo Mao et al.   JOURNAL OF STRUCTURAL BIOLOGY

Molecular-Level Evidence of the Surface-Induced Transformation of Peptide Structures Revealed by Scanning Tunneling Microscopy

(2009) Xiaobo Mao et al.   LANGMUIR

Chaperon-Mediated Single Molecular Approach Toward Modulating Aβ Peptide Aggregation

(2009) Lei Liu et al.   NANO LETTERS

Gatekeeper residues in the major curlin subunit modulate bacterial amyloid fiber biogenesis

(2009) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localized and efficient curli nucleation requires the chaperone-like amyloid assembly protein CsgF

(2009) Ashley A. Nenninger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-Like Adhesins Produced by Floc-Forming and Filamentous Bacteria in Activated Sludge

(2008) P. Larsen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Molecular Basis of Functional Bacterial Amyloid Polymerization and Nucleation

(2008) Xuan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence Determinants of Bacterial Amyloid Formation

(2008) Xuan Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Urea modulation of β-amyloid fibril growth: Experimental studies and kinetic models

(2004) Jin Ryoun Kim et al.   PROTEIN SCIENCE