Multiple Protective Roles of Nanoliposome‐Incorporated Baicalein against Alpha‐Synuclein Aggregates

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Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer’s Disease-Related Pathology in APP/PS-1 Mice

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Mesenchymal Stem Cells-derived Exosomes: A New Possible Therapeutic Strategy for Parkinson’s Disease?

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Mechanistic Understanding of the Interactions between Nano-Objects with Different Surface Properties and α-Synuclein

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Binding of Noradrenaline to native and intermediate states during fibrillation of α-Synuclein leads to the formation of stable and structured cytotoxic species

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The primary neuronal cells are more resistant than PC12 cells to α-synuclein toxic aggregates

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Bone Marrow Mesenchymal Stem Cells' Secretome Exerts Neuroprotective Effects in a Parkinson's Disease Rat Model

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Formulation and anti-neurotoxic activity of baicalein-incorporating neutral nanoliposome

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Detection and differentiation of α-Synuclein monomer and fibril by chitosan film coated nanogold array on optical sensor platform

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The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease

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(2018) Callum Ross et al.   International Journal of Nanomedicine

Baicalein Promotes Neuronal and Behavioral Recovery After Intracerebral Hemorrhage Via Suppressing Apoptosis, Oxidative Stress and Neuroinflammation

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Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species

(2017) Florencia González-Lizárraga et al.   Scientific Reports

Amylin Amyloid Inhibition by Flavonoid Baicalein: Key Roles of Its Vicinal Dihydroxyl Groups of the Catechol Moiety

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Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease

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Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo

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Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles Inhibit α-Synuclein Fibrillation and Reduce Its Cytotoxicity-Associated Effects

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Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

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Gallic acid loaded onto polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA-GA NPs) stabilizes α-synuclein in the unfolded conformation and inhibits aggregation

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Essential Oils May Leadα-Synuclein towards Toxic Fibrils Formation

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Cholesterol facilitates interactions between α-synuclein oligomers and charge-neutral membranes

(2015) Andreas van Maarschalkerweerd et al.   FEBS LETTERS

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(2015) Giuseppina Bozzuto et al.   International Journal of Nanomedicine

Strong interactions with polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA NPs) alter α-synuclein conformation and aggregation kinetics

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Small Liposomes Accelerate the Fibrillation of Amyloid β (1–40)

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How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicityin Vitro

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Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

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The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes

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Protein fibrillation and nanoparticle interactions: opportunities and challenges

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Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

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Strategies to increase the reproducibility of protein fibrillization in plate reader assays

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Interaction of baicalein and copper with α-synuclein: Electrochemical approach to Parkinson’s Disease

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Molecular Mechanisms Underlying the Flavonoid-Induced Inhibition of α-Synuclein Fibrillation

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Inducible over-expression of wild type α-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death

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α-Synuclein and neuronal cell death

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Fitting Neurological Protein Aggregation Kinetic Data via a 2-Step, Minimal/“Ockham's Razor” Model:  The Finke−Watzky Mechanism of Nucleation Followed by Autocatalytic Surface Growth†

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Structural Characteristics of α-Synuclein Oligomers Stabilized by the Flavonoid Baicalein

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