Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents

Structural and functional characterization of the Curli adaptor protein CsgF

(2018) Tobias Schubeis et al.   FEBS LETTERS

Reciprocal Interactions between Membrane Bilayers and S. aureus PSMα3 Cross-α Amyloid Fibrils Account for Species-Specific Cytotoxicity

(2018) Ravit Malishev et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural changes of TasA in biofilm formation ofBacillus subtilis

(2018) Anne Diehl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical basis of amyloid fibril polymorphism

(2018) William Close et al.   Nature Communications

Treatment with D3 Removes Amyloid Deposits, Reduces Inflammation, and Improves Cognition in Aged AβPP/PS1 Double Transgenic Mice

(2018) Thomas van Groen et al.   JOURNAL OF ALZHEIMERS DISEASE

Can a Bacterial Endotoxin be a Key Factor in the Kinetics of Amyloid Fibril Formation?

(2018) Annalia Asti et al.   JOURNAL OF ALZHEIMERS DISEASE

The Microbiome and Disease: Reviewing the Links between the Oral Microbiome, Aging, and Alzheimer's Disease

(2018) Deborah K. Shoemark et al.   JOURNAL OF ALZHEIMERS DISEASE

Mimicking cross-α amyloids

(2018) Meytal Landau   Nature Chemical Biology

Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMα peptides

(2018) Nir Salinas et al.   Nature Communications

Surprisingly high stability of the Aβ oligomer eliminating all- d -enantiomeric peptide D3 in media simulating the route of orally administered drugs

(2017) Anne Elfgen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril

(2017) Einav Tayeb-Fligelman et al.   SCIENCE

Periodontitis, Microbiomes and their Role in Alzheimer’s Disease

(2017) Anna B. Pritchard et al.   Frontiers in Aging Neuroscience

The role of microbial amyloid in neurodegeneration

(2017) Robert P. Friedland et al.   PLoS Pathogens

Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution

(2017) Martin Wolff et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation

(2016) Judith Miklossy et al.   Aging-US

Influence of the amyloid dye Congo red on curli, cellulose, and the extracellular matrix in E. coli during growth and matrix purification

(2016) Courtney Reichhardt et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, d -enantiomeric peptide

(2016) Nan Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

(2016) Francesca Pistollato et al.   NUTRITION REVIEWS

Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation

(2016) Qin Shu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Periodontitis and Cognitive Decline in Alzheimer’s Disease

(2016) Mark Ide et al.   PLoS One

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination

(2016) Antonia Nicole Klein et al.   PLoS One

Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

(2016) Jonathan D. Taylor et al.   Scientific Reports

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

Herpes simplex infection and the risk of Alzheimer's disease: A nested case-control study

(2015) Hugo Lövheim et al.   Alzheimers & Dementia

Untangling a Repetitive Amyloid Sequence: Correlating Biofilm-Derived and Segmentally Labeled Curli Fimbriae by Solid-State NMR Spectroscopy

(2015) Tobias Schubeis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation

(2015) Alice Soragni et al.   MOLECULAR CELL

The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation

(2015) Margery L. Evans et al.   MOLECULAR CELL

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pharmacokinetic Properties of a Novel d-Peptide Developed to be Therapeutically Active Against Toxic β-Amyloid Oligomers

(2015) Leonie H. E. Leithold et al.   PHARMACEUTICAL RESEARCH

Congo Red Interactions with Curli-Producing E. coli and Native Curli Amyloid Fibers

(2015) Courtney Reichhardt et al.   PLoS One

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide dimer structure in an Aβ(1–42) fibril visualized with cryo-EM

(2015) Matthias Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers

(2015) Oleksandr Brener et al.   Scientific Reports

New insight into the molecular control of bacterial functional amyloids

(2015) Jonathan D. Taylor et al.   Frontiers in Cellular and Infection Microbiology

Can oral infection be a risk factor for Alzheimer's disease?

(2015) Ingar Olsen et al.   Journal of Oral Microbiology

Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase

(2015) O. Lidor et al.   Scientific Reports

Effect of Biofilms on Recalcitrance of Staphylococcal Joint Infection to Antibiotic Treatment

(2014) S. Dastgheyb et al.   JOURNAL OF INFECTIOUS DISEASES

How to Get Insight into Amyloid Structure and Formation from Infrared Spectroscopy

(2014) Sean D. Moran et al.   Journal of Physical Chemistry Letters

Structure of a Functional Amyloid Protein Subunit Computed Using Sequence Variation

(2014) Pengfei Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG

(2014) Parveen Goyal et al.   NATURE

Structure of the nonameric bacterial amyloid secretion channel

(2014) Baohua Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATR-FTIR: A “rejuvenated” tool to investigate amyloid proteins

(2013) Rabia Sarroukh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Activation of innate immunity by lysozyme fibrils is critically dependent on cross-β sheet structure

(2013) Adelin Gustot et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Modulation of Curli Assembly and Pellicle Biofilm Formation by Chemical and Protein Chaperones

(2013) Emma K. Andersson et al.   CHEMISTRY & BIOLOGY

Biofilm Inhibitors that Target Amyloid Proteins

(2013) Diego Romero et al.   CHEMISTRY & BIOLOGY

Microbial amyloids – functions and interactions within the host

(2013) Kelly Schwartz et al.   CURRENT OPINION IN MICROBIOLOGY

Chemical attenuation of pilus function and assembly in Gram-negative bacteria

(2013) Alvin W.H. Lo et al.   CURRENT OPINION IN MICROBIOLOGY

Use of milk amyloid A in the diagnosis of subclinical mastitis in dairy ewes

(2013) Arianna Miglio et al.   JOURNAL OF DAIRY RESEARCH

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Sequence-specific determination of protein and peptide concentrations by absorbance at 205 nm

(2013) Nicholas J. Anthis et al.   PROTEIN SCIENCE

Bacterial curli protein promotes the conversion of PAP248-286into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences

(2013) Kevin Hartman et al.   PeerJ

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

(2012) María Soledad Celej et al.   BIOCHEMICAL JOURNAL

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Design and Synthesis of Fluorescent Pilicides and Curlicides: Bioactive Tools to Study Bacterial Virulence Mechanisms

(2012) Erik Chorell- et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tannic Acid Inhibits Staphylococcus aureus Surface Colonization in an IsaA-Dependent Manner

(2012) David E. Payne et al.   INFECTION AND IMMUNITY

Promiscuous Cross-seeding between Bacterial Amyloids Promotes Interspecies Biofilms

(2012) Yizhou Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Protein Oligomerization: Inhibitor of Functional Amyloids Templates α-Synuclein Fibrillation

(2012) Istvan Horvath et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Survey of Peptides with Effective Therapeutic Potential in Alzheimer’s Disease Rodent Models or in Human Clinical Studies

(2012) N. Sun et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Two-dimensional IR spectroscopy and segmental 13C labeling reveals the domain structure of human  D-crystallin amyloid fibrils

(2012) S. D. Moran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial manipulation of the amyloid fold

(2012) William H. DePas et al.   RESEARCH IN MICROBIOLOGY

Functional Amyloids Composed of Phenol Soluble Modulins Stabilize Staphylococcus aureus Biofilms

(2012) Kelly Schwartz et al.   PLoS Pathogens

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Fibrillation of the Major Curli Subunit CsgA under a Wide Range of Conditions Implies a Robust Design of Aggregation

(2011) Morten S. Dueholm et al.   BIOCHEMISTRY

Atomic Resolution Insights into Curli Fiber Biogenesis

(2011) Jonathan D. Taylor et al.   STRUCTURE

Diversity, biogenesis and function of microbial amyloids

(2011) Luz P. Blanco et al.   TRENDS IN MICROBIOLOGY

Oral Treatment with the d-Enantiomeric Peptide D3 Improves the Pathology and Behavior of Alzheimer’s Disease Transgenic Mice

(2010) Susanne Aileen Funke et al.   ACS Chemical Neuroscience

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Yeast Toxic Mutant of HET-s(218-289) Prion Displays Alternative Intermediates of Amyloidogenesis

(2010) Karine Berthelot et al.   BIOPHYSICAL JOURNAL

Transformation of amyloid β(1–40) oligomers into fibrils is characterized by a major change in secondary structure

(2010) Rabia Sarroukh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural Similarity between the Prion Domain of HET-s and a Homologue Can Explain Amyloid Cross-Seeding in Spite of Limited Sequence Identity

(2010) Christian Wasmer et al.   JOURNAL OF MOLECULAR BIOLOGY

Atomic-Resolution Three-Dimensional Structure of HET-s(218−289) Amyloid Fibrils by Solid-State NMR Spectroscopy

(2010) Hélène Van Melckebeke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Amyloid-Like Protein Inclusions in Tobacco Transgenic Plants

(2010) Anna Villar-Piqué et al.   PLoS One

Identifying the amylome, proteins capable of forming amyloid-like fibrils

(2010) Lukasz Goldschmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide

(2009) Emilie Cerf et al.   BIOCHEMICAL JOURNAL

The Functional Curli Amyloid Is Not Based on In-register Parallel β-Sheet Structure

(2009) Frank Shewmaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Common Architecture of Cross-β Amyloid

(2009) Thomas R. Jahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

(2009) Lynette Cegelski et al.   Nature Chemical Biology

Molecular mechanisms for protein-encoded inheritance

(2009) Jed J W Wiltzius et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gatekeeper residues in the major curlin subunit modulate bacterial amyloid fiber biogenesis

(2009) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Acceleration of murine AA amyloid deposition by bovine amyloid fibrils and tissue homogenates

(2008) Dan Cui et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Reduction of Alzheimer’s Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-Enantiomeric Peptide Identified by Mirror Image Phage Display

(2008) Thomas van Groen et al.   ChemMedChem

Sequence Determinants of Bacterial Amyloid Formation

(2008) Xuan Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Prediction of Aggregation-Prone Regions in Structured Proteins

(2008) Gian Gaetano Tartaglia et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of cytotoxicity and amyloid fibril formation by a D-amino acid peptide that specifically binds to Alzheimer's disease amyloid peptide

(2008) K. Wiesehan et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE

FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils

(2004) Giorgia Zandomeneghi et al.   PROTEIN SCIENCE