Controllable Single and Double Difluoromethylene Insertions into C–Cu Bonds: Copper-Mediated Tetrafluoroethylation and Hexafluoropropylation of Aryl Iodides with TMSCF2H and TMSCF2Br

Synthesis and study of amphiphilic properties of polyfluoroalkylethyl ethers

(2022) A.S. Tsyrulnikova et al.   JOURNAL OF FLUORINE CHEMISTRY

CF3-substituted carbocations: underexploited intermediates with great potential in modern synthetic chemistry

(2021) Anthony J Fernandes et al.   Beilstein Journal of Organic Chemistry

Synthesis of Difluorinated Heterocyclics through Metal-Free [8+1] and [4+1] Cycloaddition of Difluorocarbene

(2021) Yimin Jia et al.   ORGANIC LETTERS

Mechanistic Insight into Copper-Mediated Trifluoromethylation of Aryl Halides: The Role of CuI

(2021) He Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Difluoroalkylated Heteroarenes via Difluorocarbene

(2021) Alexey L. Trifonov et al.   ORGANIC LETTERS

TMSCF 2 Br‐Enabled Fluorination–Aminocarbonylation of Aldehydes: Modular Access to α‐Fluoroamides

(2021) An Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Difluorocarbene‐Induced Ring‐Opening Difluoromethylation‐Halogenation of Cyclic (Thio)Ethers with TMSCF 2 X (X=Br, Cl)**

(2021) Rongyi Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

From C1 to C3: Copper-Catalyzed gem-Bis(trifluoromethyl)olefination of α-Diazo Esters with TMSCF3

(2020) Jinbo Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Where does the Fluorine come from? A review on the challenges associated with the synthesis of organofluorine compounds.

(2020) Stephane Caron   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Preparation of 1-Azido-2-bromo-1,1,2,2-tetrafluoroethane and its Use in the Synthesis of N-Fluoroalkylated Nitrogen Heterocycles

(2020) David Tichy et al.   JOURNAL OF ORGANIC CHEMISTRY

Difluoroketenimine: Generation from Difluorocarbene and Isocyanide and Its [3 + 2] Cycloadditions with Alkenes or Alkynes

(2020) Rui Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Difluorocarbene Generation from TMSCF3: Kinetics and Mechanism of NaI-Mediated and Si-Induced Anionic Chain Reactions

(2020) Andrés García-Domínguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Defluorinative Ring‐Opening Indolylation of Siloxydifluorocyclopropanes: Controlled Synthesis of α‐Fluoro‐β‐Indolyl‐Propanones for Carbazole Construction

(2020) Xiaowei Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Ring-opening functionalizations of unstrained cyclic amines enabled by difluorocarbene transfer

(2020) Youyoung Kim et al.   Nature Communications

Current Contributions of Organofluorine Compounds to the Agrochemical Industry

(2020) Yuta Ogawa et al.   iScience

The Generation of Difluoroketenimine and Its Application in the Synthesis of α,α-Difluoro-β-amino Amides

(2019) Rui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General C-H Difluoromethylation Protocol for Carbon Acids Using TMSCF2Br

(2019) Jinbo Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?

(2019) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Copper Complex-Catalyzed Hydrodefluorination of Fluoroalkenes and Allyl Fluorides: A Tale of Two Mechanisms

(2019) Nicholas O. Andrella et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controllable catalytic difluorocarbene transfer enables access to diversified fluoroalkylated arenes

(2019) Xia-Ping Fu et al.   Nature Chemistry

Applications of fluorine-containing amino acids for drug design

(2019) Haibo Mei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

“Ligandless” Pentafluoroethylation of Unactivated (Hetero)aryl and Alkenyl Halides Enabled by the Controlled Self-Condensation of TMSCF3-Derived CuCF3

(2019) Jordi Mestre et al.   JOURNAL OF ORGANIC CHEMISTRY

Nucleophilic (Phenylsulfonyl/arylthio)difluoromethylation of Aldehydes with TMSCF2Br: A Three-Component Strategy

(2019) Qiqiang Xie et al.   ORGANIC LETTERS

Highly C-selective difluoromethylation of β-ketoesters by using TMSCF2Br/lithium hydroxide/N,N,N-trimethylhexadecan-1-ammonium bromide

(2018) Jiandong Wang et al.   CHEMICAL COMMUNICATIONS

Advances in the Synthesis and Application of Tetrafluoroethylene- and 1,1,2,2-Tetrafluoroethyl-Containing Compounds

(2018) Jiří Václavík et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

From C1 to C2 : TMSCF3 as a Precursor for Pentafluoroethylation

(2018) Qiqiang Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

(2017) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

CF2H, a Hydrogen Bond Donor

(2017) Chanan D. Sessler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis, Reactivity, and Catalytic Applications of Isolable (NHC)Cu(CHF2) Complexes

(2017) James R. Bour et al.   ORGANOMETALLICS

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Unexpected “reverse” cyclization of 2-mercaptobenzimidazole with chlorotrifluoroethylene and hexafluoropropene

(2016) Kirill I. Petko et al.   JOURNAL OF FLUORINE CHEMISTRY

Antioxidant properties in a non-polar environment of difluoromethyl bioisosteres of methyl hydroxycinnamates

(2016) Mario D. Martínez et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Polyfluoroethoxy derivatives of malonic aldehyde acetal in the synthesis of heterocyclic compounds

(2015) Taras M. Sokolenko et al.   Chemistry of Heterocyclic Compounds

Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF2H

(2015) Sheng-Qing Zhu et al.   Organic Chemistry Frontiers

Efficient Synthesis of Empagliflozin, an Inhibitor of SGLT-2, Utilizing an AlCl3-Promoted Silane Reduction of a β-Glycopyranoside

(2014) Xiao-jun Wang et al.   ORGANIC LETTERS

Termite (order Blattodea, infraorder Isoptera) baiting 20 years after commercial release

(2014) Theodore A Evans et al.   PEST MANAGEMENT SCIENCE

Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature

(2014) Xue-Liang Jiang et al.   Organic Chemistry Frontiers

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes

(2010) Fei Wang et al.   CHEMICAL COMMUNICATIONS

Selective difluoromethylation and monofluoromethylation reactions

(2009) Jinbo Hu et al.   CHEMICAL COMMUNICATIONS

The solid complex Zn(CF3)Br·2DMF as an alternative reagent for the preparation of both, trifluoromethyl and pentafluoroethyl copper, CuCF3 and CuC2F5

(2009) Mikhail M. Kremlev et al.   JOURNAL OF FLUORINE CHEMISTRY