Difluorocarbene‐Induced Ring‐Opening Difluoromethylation‐Halogenation of Cyclic (Thio)Ethers with TMSCF 2 X (X=Br, Cl)**

Modulation of the H-Bond Basicity of Functional Groups by α-Fluorine-Containing Functions and its Implications for Lipophilicity and Bioisosterism

(2021) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Difluorinated Heterocyclics through Metal-Free [8+1] and [4+1] Cycloaddition of Difluorocarbene

(2021) Yimin Jia et al.   ORGANIC LETTERS

Synthesis of Difluoroalkylated Heteroarenes via Difluorocarbene

(2021) Alexey L. Trifonov et al.   ORGANIC LETTERS

Chemoselective N- and O-Difluoromethylation of 2-Pyridones, Isoquinolinones, and Quinolinones with TMSCF2Br

(2021) Ziyue Zhu et al.   ORGANIC LETTERS

Contribution of Organofluorine Compounds to Pharmaceuticals

(2020) Munenori Inoue et al.   ACS Omega

Fluorinated Ylides/Carbenes and Related Intermediates from Phosphonium/Sulfonium Salts

(2020) Jin-Hong Lin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Difluoroketenimine: Generation from Difluorocarbene and Isocyanide and Its [3 + 2] Cycloadditions with Alkenes or Alkynes

(2020) Rui Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Defluorinative Ring‐Opening Indolylation of Siloxydifluorocyclopropanes: Controlled Synthesis of α‐Fluoro‐β‐Indolyl‐Propanones for Carbazole Construction

(2020) Xiaowei Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Difluorocarbene-Triggered Cyclization: Synthesis of (Hetero)arene-Fused 2,2-Difluoro-2,3-dihydrothiophenes

(2020) Huamin Liang et al.   ORGANIC LETTERS

Difluoromethylation of Alcohols with TMSCF2Br in Water: A New Insight into the Generation and Reactions of Difluorocarbene in a Two-Phase System

(2020) Rongyi Zhang et al.   TETRAHEDRON

Ring-opening functionalizations of unstrained cyclic amines enabled by difluorocarbene transfer

(2020) Youyoung Kim et al.   Nature Communications

Deconstructive Functionalizations of Unstrained Carbon–Nitrogen Cleavage Enabled by Difluorocarbene

(2020) Jianke Su et al.   ACS Central Science

Current Contributions of Organofluorine Compounds to the Agrochemical Industry

(2020) Yuta Ogawa et al.   iScience

Application of carbene chemistry in the synthesis of organofluorine compounds

(2019) Xuyong Wang et al.   TETRAHEDRON

The Generation of Difluoroketenimine and Its Application in the Synthesis of α,α-Difluoro-β-amino Amides

(2019) Rui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General C-H Difluoromethylation Protocol for Carbon Acids Using TMSCF2Br

(2019) Jinbo Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Tri- and Difluoromethoxylated Compounds by Visible-Light Photoredox Catalysis

(2019) Johnny W. Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Difluoromethylation of Phenols and Thiophenols with the S-(Difluo-romethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study

(2019) Guo-Kai Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Nucleophilic (Phenylsulfonyl/arylthio)difluoromethylation of Aldehydes with TMSCF2Br: A Three-Component Strategy

(2019) Qiqiang Xie et al.   ORGANIC LETTERS

Difluorocarbene as a Building Block for Consecutive Bond-Forming Reactions

(2018) Alexander D. Dilman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly C-selective difluoromethylation of β-ketoesters by using TMSCF2Br/lithium hydroxide/N,N,N-trimethylhexadecan-1-ammonium bromide

(2018) Jiandong Wang et al.   CHEMICAL COMMUNICATIONS

Recent advances in carbon-difluoroalkylation and -difluoroolefination with difluorocarbene

(2018) Weigang Zhang et al.   TETRAHEDRON LETTERS

Triple Mode of Alkylation with Ethyl Bromodifluoroacetate: N , or O -Difluoromethylation, N -Ethylation and S -(ethoxycarbonyl)difluoromethylation

(2018) Arghya Polley et al.   ADVANCED SYNTHESIS & CATALYSIS

From C1 to C2 : TMSCF3 as a Precursor for Pentafluoroethylation

(2018) Qiqiang Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

(2017) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Visible-Light Photoredox Difluoromethylation of Phenols and Thiophenols with Commercially Available Difluorobromoacetic Acid

(2017) Jinyan Yang et al.   ORGANIC LETTERS

Direct Difluoromethylation of Alcohols with an Electrophilic Difluoromethylated Sulfonium Ylide

(2016) Jiansheng Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Decarboxylative Trifluoromethylating Reagent [Cu(O2 CCF3 )(phen)] and Difluorocarbene Precursor [Cu(phen)2 ][O2 CCF2 Cl]

(2016) Xiaoxi Lin  et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Catalyzed O-Difluoromethylation of Functionalized Aliphatic Alcohols: Access to Complex Organic Molecules with an OCF2H Group

(2016) Kostiantyn Levchenko et al.   JOURNAL OF ORGANIC CHEMISTRY

18F-Labeling of Aryl-SCF3, -OCF3and -OCHF2with [18F]Fluoride

(2015) Tanatorn Khotavivattana et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation

(2015) Xiao-Yun Deng et al.   CHEMICAL COMMUNICATIONS

Three step procedure for the preparation of aromatic and aliphatic difluoromethyl ethers from phenols and alcohols using a chlorine/fluorine exchange methodology

(2014) William R. Dolbier et al.   JOURNAL OF FLUORINE CHEMISTRY

Recent Advances in the Synthetic Application of Difluorocarbene

(2014) Jinbo Hu et al.   SYNTHESIS-STUTTGART

Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles

(2013) Xin Guo et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis ofgem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF2Br

(2013) Lingchun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate

(2013) Patrick S. Fier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intramolecular generation and rearrangement of oxonium ylides: methodology studies and their application in synthesis

(2013) Graham K. Murphy et al.   TETRAHEDRON

Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes

(2010) Fei Wang et al.   CHEMICAL COMMUNICATIONS

Reactivity of a Hypervalent Iodine Trifluoromethylating Reagent toward THF: Ring Opening and Formation of Trifluoromethyl Ethers

(2010) Serena Fantasia et al.   JOURNAL OF ORGANIC CHEMISTRY

New trends in the chemistry of α-fluorinated ethers, thioethers, amines and phosphines

(2009) Baptiste Manteau et al.   JOURNAL OF FLUORINE CHEMISTRY

Recent studies on the reactions of α-diazocarbonyl compounds

(2008) Zhenhua Zhang et al.   TETRAHEDRON

A general route for constructing difluoromethyl ethers

(2008) Youlia Hagooly et al.   TETRAHEDRON LETTERS