Synthesis of Difluorinated Heterocyclics through Metal-Free [8+1] and [4+1] Cycloaddition of Difluorocarbene

Fluorinated Ylides/Carbenes and Related Intermediates from Phosphonium/Sulfonium Salts

(2020) Jin-Hong Lin et al.   ACCOUNTS OF CHEMICAL RESEARCH

F–-Free Deoxyhydrotrifluoromethylation of α-Keto Esters with Ph3P+CF2CO2–: Synthesis of α–CF3-Substituted Esters

(2020) Ying Zheng et al.   JOURNAL OF ORGANIC CHEMISTRY

Difluorocarbene Generation from TMSCF3: Kinetics and Mechanism of NaI-Mediated and Si-Induced Anionic Chain Reactions

(2020) Andrés García-Domínguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chlorotrifluoromethylthiolation of Sulfur Ylides for the Formation of Tetrasubstituted Trifluoromethylthiolated Alkenes

(2020) Na Wang et al.   ORGANIC LETTERS

A General C-H Difluoromethylation Protocol for Carbon Acids Using TMSCF2Br

(2019) Jinbo Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Tri- and Difluoromethoxylated Compounds by Visible-Light Photoredox Catalysis

(2019) Johnny W. Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Approaches to Obtaining Fluorinated α-Amino Acids

(2019) Johann Moschner et al.   CHEMICAL REVIEWS

Controllable catalytic difluorocarbene transfer enables access to diversified fluoroalkylated arenes

(2019) Xia-Ping Fu et al.   Nature Chemistry

Oxidation of difluorocarbene and subsequent trifluoromethoxylation

(2019) Jiao Yu et al.   Nature Communications

Difluorocarbene as a Building Block for Consecutive Bond-Forming Reactions

(2018) Alexander D. Dilman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly C-selective difluoromethylation of β-ketoesters by using TMSCF2Br/lithium hydroxide/N,N,N-trimethylhexadecan-1-ammonium bromide

(2018) Jiandong Wang et al.   CHEMICAL COMMUNICATIONS

A chiral scandium-complex-catalyzed asymmetric inverse-electron-demand oxa-Diels–Alder reaction of o-quinone methides with fulvenes

(2018) Jianlin Zhang et al.   CHEMICAL COMMUNICATIONS

Construction of Polycyclic Indole Derivatives via Multiple Aryne Reactions with Azaheptafulvenes

(2018) Zhen Wang et al.   ORGANIC LETTERS

Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides

(2018) Zhang Feng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium

(2017) Zhang Feng et al.   Nature Chemistry

Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine

(2016) Yingle Liu et al.   CHEMICAL COMMUNICATIONS

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations

(2016) Chuanfa Ni et al.   CHEMICAL SOCIETY REVIEWS

Copper(I)-Catalyzed [4 + 1] Cycloaddition of Silyl Dienol Ethers with Sodium Bromodifluoroacetate: Access to β,β-Difluorocyclopentanone Derivatives

(2016) Kohei Fuchibe et al.   ORGANIC LETTERS

Pd-Catalyzed Transfer of Difluorocarbene

(2016) Xiao-Yun Deng et al.   ORGANIC LETTERS

Copper-Catalyzed Intermolecular Chloro- and Bromotrifluoromethylation of Alkenes

(2016) Mingyang Fu et al.   ORGANIC LETTERS

Nucleophilic Difluoromethylation Using (Bromodifluoromethyl)trimethylsilane

(2016) Alexey L. Trifonov et al.   ORGANIC LETTERS

Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation

(2015) Xiao-Yun Deng et al.   CHEMICAL COMMUNICATIONS

Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp2) and C(sp) Centers

(2015) Marie-Charlotte Belhomme et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biological and medicinal significance of benzofuran

(2015) Reshma J. Nevagi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

gem-Difluoroolefination of Diazo Compounds with TMSCF3 or TMSCF2Br: Transition-Metal-Free Cross-Coupling of Two Carbene Precursors

(2015) Mingyou Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)-Promoted Decomposition of Difluorocarbene and the Subsequent Trifluoromethylation

(2015) Jian Zheng et al.   ORGANIC LETTERS

Cross-Coupling between Difluorocarbene and Carbene-Derived Intermediates Generated from Diazocompounds for the Synthesis of gem-Difluoroolefins

(2015) Jian Zheng et al.   ORGANIC LETTERS

Access to Difluoromethylated Arenes by Pd-Catalyzed Reaction of Arylboronic Acids with Bromodifluoroacetate

(2015) Zhang Feng et al.   ORGANIC LETTERS

Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

(2014) Chuanfa Ni et al.   CHEMICAL REVIEWS

Successful fluorine-containing herbicide agrochemicals

(2014) Tomoya Fujiwara et al.   JOURNAL OF FLUORINE CHEMISTRY

Recent Advances in the Synthetic Application of Difluorocarbene

(2014) Jinbo Hu et al.   SYNTHESIS-STUTTGART

N-Heterocyclic Carbene Catalyzed [4+3] Annulation of Enals ando-Quinone Methides: Highly Enantioselective Synthesis of Benzo-ε-Lactones

(2013) Hui Lv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric [8+2] Cycloaddition: Synthesis of Cycloheptatriene-Fused Pyrrole Derivatives

(2013) Mingsheng Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis ofgem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF2Br

(2013) Lingchun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

(2013) Jian Zheng et al.   CHEMICAL COMMUNICATIONS

Conversion between Difluorocarbene and Difluoromethylene Ylide

(2013) Jian Zheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Use of Fluoroform as a Source of Difluorocarbene in the Synthesis of Difluoromethoxy- and Difluorothiomethoxyarenes

(2013) Charles S. Thomoson et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient Difluoromethylation of sp3Carbon Nucleophiles by Bromodifluoromethylation Reagents with Organic Bases

(2012) Guokai Liu et al.   ChemistryOpen

Synthesis of gem-Difluorinated Cyclopropanes and Cyclopropenes: Trifluoromethyltrimethylsilane as a Difluorocarbene Source

(2011) Fei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Azetidines: New Tools for the Synthesis of Nitrogen Heterocycles

(2009) François Couty et al.   SYNLETT

Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions

(2008) Jun-An Ma et al.   CHEMICAL REVIEWS

Nucleophilic difluoromethylation and trifluoromethylation using tetrakis(dimethylamino)ethylene (TDAE) reagent

(2008) Maurice Médebielle et al.   JOURNAL OF FLUORINE CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS