Synthesis of Difluoroalkylated Heteroarenes via Difluorocarbene

Base-Catalyzed H/D Exchange Reaction of Difluoromethylarenes

(2021) Linwei Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

Frustrated Lewis-Pair-Meditated Selective Single Fluoride Substitution in Trifluoromethyl Groups

(2020) Dipendu Mandal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds

(2020) Benjamin M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery

(2020) Jeroen B. I. Sap et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Contribution of Organofluorine Compounds to Pharmaceuticals

(2020) Munenori Inoue et al.   ACS Omega

Deprotonative Functionalization of the Difluoromethyl Group

(2020) Laura Santos et al.   ORGANIC LETTERS

Current Contributions of Organofluorine Compounds to the Agrochemical Industry

(2020) Yuta Ogawa et al.   iScience

Selective Defluoroallylation of Trifluoromethylarenes

(2019) Chaosheng Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective C–F Functionalization of Unactivated Trifluoromethylarenes

(2019) David B. Vogt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Difluorocarbene as a Building Block for Consecutive Bond-Forming Reactions

(2018) Alexander D. Dilman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides

(2018) Zhang Feng et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Difluoromethyl Group as a Masked Nucleophile: A Lewis Acid/Base Approach

(2018) Jacob B. Geri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Late-Stage Hydrodefluorination of Trifluoromethylarenes: A Facile Access to Difluoromethylarenes

(2017) Socrates B. Munoz et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Defluoroalkylation of Trifluoromethylaromatics with Unactivated Alkenes

(2017) Hengbin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Single C(sp3)–F Bond Cleavage in Trifluoromethylarenes: Merging Visible-Light Catalysis with Lewis Acid Activation

(2017) Kang Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Difluoromethylation of Carboxylic Acids via the Addition of Difluorinated Phosphorus Ylide to Acyl Chlorides

(2017) Alexey L. Trifonov et al.   ORGANIC LETTERS

Pyridines and Imidazopyridines with Medicinal Significance

(2016) Tara L.S. Kishbaugh   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Nucleophilic 1,1-Difluoroethylation with Fluorinated Phosphonium Salt

(2016) Zuyong Deng et al.   JOURNAL OF ORGANIC CHEMISTRY

Radicals: Reactive Intermediates with Translational Potential

(2016) Ming Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Nucleophilic Difluoromethylation of Carbonyl Compounds

(2016) Zuyong Deng et al.   ORGANIC LETTERS

Reactions of gem-Difluorinated Phosphonium Salts Induced by Light

(2016) Liubov I. Panferova et al.   ORGANIC LETTERS

Nucleophilic Difluoromethylation Using (Bromodifluoromethyl)trimethylsilane

(2016) Alexey L. Trifonov et al.   ORGANIC LETTERS

Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide

(2015) Qing-Yu Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp2) and C(sp) Centers

(2015) Marie-Charlotte Belhomme et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selective Incorporation of Difluoromethylene Moieties into Arenes Assisted by Transition Metals

(2014) Bing Gao et al.   CHIMIA

Nucleophilic Bromodifluoromethylation of Iminium Ions

(2014) Artem V. Tsymbal et al.   JOURNAL OF ORGANIC CHEMISTRY

Difluoromethylene Phosphabetaine as an Equivalent of Difluoromethyl Carbanion

(2014) Vitalij V. Levin et al.   ORGANIC LETTERS

Recent Advances in the Synthetic Application of Difluorocarbene

(2014) Jinbo Hu et al.   SYNTHESIS-STUTTGART

Direct Synthesis of Fluorinated Heteroarylether Bioisosteres

(2013) Qianghui Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis ofgem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF2Br

(2013) Lingchun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

(2013) Marcus Baumann et al.   Beilstein Journal of Organic Chemistry

Conversion between Difluorocarbene and Difluoromethylene Ylide

(2013) Jian Zheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Difluoro(trimethylsilyl)acetonitrile: Synthesis and Fluoroalkylation Reactions

(2012) Mikhail D. Kosobokov et al.   JOURNAL OF ORGANIC CHEMISTRY

Nucleophilic fluoroalkylation of iminium salts

(2008) Vitalij V. Levin et al.   TETRAHEDRON LETTERS