DJ ‐1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons

Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite

(2022) Isaac P. Heremans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation

(2021) Melissa Conti Mazza et al.   Stem Cell Research

A continuous spectrophotometric assay for glutathione-independent glyoxalases

(2021) Tomiris Mulikova et al.   ANALYTICAL BIOCHEMISTRY

DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein

(2021) Tamr B. Atieh et al.   Biomolecules

Reversible histone glycation is associated with disease-related changes in chromatin architecture

(2019) Qingfei Zheng et al.   Nature Communications

The deglycase activity of DJ-1 mitigates α-synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ-1 in Parkinson's disease

(2019) Neelam Sharma et al.   FREE RADICAL BIOLOGY AND MEDICINE

A role for DJ-1 against oxidative stress in the mammalian retina

(2019) José Martín-Nieto et al.   NEUROSCIENCE LETTERS

The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells

(2019) Karim Bahmed et al.   Cell Death & Disease

The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals

(2019) Anna Andreeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Further characterization of the Maillard deglycase DJ-1 and its prokaryotic homologs, deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL

(2018) Gilbert Richarme et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Product Studies and Mechanistic Analysis of the Reaction of Methylglyoxal with Deoxyguanosine

(2018) Sarah C. Shuck et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Glutathione depletion triggers actin cytoskeleton changes via actin-binding proteins

(2018) Nahum Zepeta-Flores et al.   GENETICS AND MOLECULAR BIOLOGY

Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress

(2018) Shaoqing Xu et al.   JOURNAL OF NEUROCHEMISTRY

Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks

(2018) James J. Galligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin

(2018) Yuichiro Mita et al.   Scientific Reports

Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

(2018) Matthew CW Oswald et al.   eLife

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs

(2017) Gilbert Richarme et al.   SCIENCE

Parkinson’s disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro

(2017) Noriyuki Matsuda et al.   Scientific Reports

DJ-1 Modulates Nuclear Erythroid 2–Related Factor-2–Mediated Protection in Human Primary Alveolar Type II Cells in Smokers

(2016) Karim Bahmed et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification

(2016) Daniel H. Pfaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity

(2016) Kiran Aslam et al.   Prion

The Oxidation States of DJ-1 Dictate the Cell Fate in Response to Oxidative Stress Triggered by 4-HPR: Autophagy or Apoptosis?

(2014) Ji Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe

(2014) Qiaoqiao Zhao et al.   BMC EVOLUTIONARY BIOLOGY

Stereospecific mechanism of DJ-1 glyoxalases inferred from their hemithioacetal-containing crystal structures

(2014) Dongwook Choi et al.   FEBS Journal

A new split-GFP-based probe reveals DJ-1 translocation into the mitochondrial matrix to sustain ATP synthesis upon nutrient deprivation

(2014) Tito Calì et al.   HUMAN MOLECULAR GENETICS

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

(2014) Gilbert Richarme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transnitrosylation from DJ-1 to PTEN Attenuates Neuronal Cell Death in Parkinson's Disease Models

(2014) M. S. Choi et al.   JOURNAL OF NEUROSCIENCE

Novel glyoxalases fromArabidopsis thaliana

(2013) Kyu Kwon et al.   FEBS Journal

Identification of the recognition sequence and target proteins for DJ-1 protease

(2013) Hitomi Mitsugi et al.   FEBS LETTERS

A Glutathione-independent Glyoxalase of the DJ-1 Superfamily Plays an Important Role in Managing Metabolically Generated Methylglyoxal inCandida albicans

(2013) Sahar Hasim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)

(2013) Karen G. Shadrach et al.   PLoS One

Conservation of Oxidative Protein Stabilization in an Insect Homologue of Parkinsonism-Associated Protein DJ-1

(2012) Jiusheng Lin et al.   BIOCHEMISTRY

Human DJ-1 and its homologs are novel glyoxalases

(2012) Ju-young Lee et al.   HUMAN MOLECULAR GENETICS

Role of Renal DJ-1 in the Pathogenesis of Hypertension Associated With Increased Reactive Oxygen Species Production

(2012) Santiago Cuevas et al.   HYPERTENSION

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Proteomics analysis identifies PARK7 as an important player for renal cell resistance and survival under oxidative stress

(2011) Marwa Eltoweissy et al.   Molecular BioSystems

Hsp31 of Escherichia coli K-12 is glyoxalase III

(2011) Krishna P. Subedi et al.   MOLECULAR MICROBIOLOGY

Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage

(2010) Jue Chen et al.   HUMAN MOLECULAR GENETICS

Evolution of New Enzymatic Function by Structural Modulation of Cysteine Reactivity inPseudomonas fluorescensIsocyanide Hydratase

(2010) Mahadevan Lakshminarasimhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidizable Residues Mediating Protein Stability and Cytoprotective Interaction of DJ-1 with Apoptosis Signal-regulating Kinase 1

(2009) Jens Waak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

(2009) Jeff Blackinton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FitSpace Explorer: An algorithm to evaluate multidimensional parameter space in fitting kinetic data

(2008) Kenneth A. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Global Kinetic Explorer: A new computer program for dynamic simulation and fitting of kinetic data

(2008) Kenneth A. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Cysteine pKaDepression by a Protonated Glutamic Acid in Human DJ-1†‡

(2008) Anna C. Witt et al.   BIOCHEMISTRY

Mitochondrial localization of DJ-1 leads to enhanced neuroprotection

(2008) Eunsung Junn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

(2008) M. P. van der Brug et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA