The Oxidation States of DJ-1 Dictate the Cell Fate in Response to Oxidative Stress Triggered by 4-HPR: Autophagy or Apoptosis?

Fenretinide induces autophagic cell death in caspase-defective breast cancer cells

(2014) Barbara Fazi et al.   Autophagy

Glucose-Regulated Protein 78 Controls Cross-talk between Apoptosis and Autophagy to Determine Antiestrogen Responsiveness

(2012) K. L. Cook et al.   CANCER RESEARCH

DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA

(2012) Xiangyi He et al.   CARCINOGENESIS

Bortezomib Sensitizes Human Acute Myeloid Leukemia Cells to All-Trans-Retinoic Acid-Induced Differentiation by Modifying the RAR /STAT1 Axis

(2012) M. Ying et al.   MOLECULAR CANCER THERAPEUTICS

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Phase II Study of Oral Capsular 4-Hydroxyphenylretinamide (4-HPR/Fenretinide) in Pediatric Patients with Refractory or Recurrent Neuroblastoma: A Report from the Children's Oncology Group

(2011) J. G. Villablanca et al.   CLINICAL CANCER RESEARCH

Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage

(2011) Sandrine Lépine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats

(2011) Yoshihisa Kitamura et al.   Molecular Neurodegeneration

Consequences of DJ-1 upregulation following p53 loss and cell transformation

(2011) S Vasseur et al.   ONCOGENE

The Role of Cysteine Oxidation in DJ-1 Function and Dysfunction

(2010) Mark A. Wilson   ANTIOXIDANTS & REDOX SIGNALING

Mitogen-Activated Protein Kinases in Mammalian Oxidative Stress Responses

(2010) Christopher Runchel et al.   ANTIOXIDANTS & REDOX SIGNALING

DJ-1, a cancer and Parkinson’s disease associated protein, regulates autophagy through JNK pathway in cancer cells

(2010) Haigang Ren et al.   CANCER LETTERS

Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage

(2010) Jue Chen et al.   HUMAN MOLECULAR GENETICS

Involvement of JNK in the regulation of autophagic cell death

(2010) S Shimizu et al.   ONCOGENE

Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells

(2010) Xin Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia☆

(2010) Xiao-Wen Liu et al.   PHARMACOLOGICAL RESEARCH

Suppression of Hypoxia-Inducible Factor 1α (HIF-1α) by Tirapazamine Is Dependent on eIF2α Phosphorylation Rather Than the mTORC1/4E-BP1 Pathway

(2010) Jun Zhang et al.   PLoS One

DJ-1 Loss by Glutaredoxin but Not Glutathione Depletion Triggers Daxx Translocation and Cell Death

(2009) Uzma Saeed et al.   ANTIOXIDANTS & REDOX SIGNALING

Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability

(2009) Xin Li et al.   CANCER LETTERS

The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras

(2009) Joo-Yun Byun et al.   CARCINOGENESIS

Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma

(2009) Roos Cuperus et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

(2009) Philipp J. Kahle et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells

(2009) Ji Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidizable Residues Mediating Protein Stability and Cytoprotective Interaction of DJ-1 with Apoptosis Signal-regulating Kinase 1

(2009) Jens Waak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

(2009) Jeff Blackinton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase III Prevention Trial of Fenretinide in Patients with Resected Non Muscle-Invasive Bladder Cancer

(2008) A. L. Sabichi et al.   CLINICAL CANCER RESEARCH

The PERK/eIF2α signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells

(2008) Wai-Lung Lai et al.   EXPERIMENTAL CELL RESEARCH

Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition

(2008) Yu-Jun Cai et al.   FREE RADICAL BIOLOGY AND MEDICINE

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

(2008) M. P. van der Brug et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA