DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein

Nitration and Glycation Diminish the α-Synuclein Role in the Formation and Scavenging of Cu2+-Catalyzed Reactive Oxygen Species

(2019) Humberto Martínez-Orozco et al.   ACS Chemical Neuroscience

The deglycase activity of DJ-1 mitigates α-synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ-1 in Parkinson's disease

(2019) Neelam Sharma et al.   FREE RADICAL BIOLOGY AND MEDICINE

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

(2019) Parvez Alam et al.   JOURNAL OF NEUROCHEMISTRY

The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals

(2019) Anna Andreeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Advanced Glycation on Aggregation and DNA Binding Properties of α-Synuclein

(2018) Vasudevaraju Padmaraju et al.   JOURNAL OF ALZHEIMERS DISEASE

Potential Modes of Intercellular α-Synuclein Transmission

(2017) Dario Valdinocci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs

(2017) Gilbert Richarme et al.   SCIENCE

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy

(2017) Chuan-Ying Xu et al.   Frontiers in Aging Neuroscience

Parkinson’s disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro

(2017) Noriyuki Matsuda et al.   Scientific Reports

Lysines, Achilles’ heel in alpha-synuclein conversion to a deadly neuronal endotoxin

(2016) Nicoletta Plotegher et al.   AGEING RESEARCH REVIEWS

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

(2016) Martin Ingelsson   Frontiers in Neuroscience

Glycation potentiates neurodegeneration in models of Huntington’s disease

(2016) Hugo Vicente Miranda et al.   Scientific Reports

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

(2014) Gilbert Richarme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunostaining of Oxidized DJ-1 in Human and Mouse Brains

(2014) Yoshiro Saito et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease

(2014) L Zondler et al.   Cell Death & Disease

Ubiquitin pathways in neurodegenerative disease

(2014) Graham Atkin et al.   Frontiers in Molecular Neuroscience

Site-Specific Differences in Proteasome-Dependent Degradation of Monoubiquitinated α-Synuclein

(2013) Tharindumala Abeywardana et al.   CHEMISTRY & BIOLOGY

Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence

(2013) Lijuan Kang et al.   PLoS One

Glycation exacerbates the neuronal toxicity of β-amyloid

(2013) X-H Li et al.   Cell Death & Disease

Human DJ-1 and its homologs are novel glyoxalases

(2012) Ju-young Lee et al.   HUMAN MOLECULAR GENETICS

Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Recent Advances in α-Synuclein Functions, Advanced Glycation, and Toxicity: Implications for Parkinson’s Disease

(2012) Erika Guerrero et al.   MOLECULAR NEUROBIOLOGY

N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

(2012) Lijuan Kang et al.   PROTEIN SCIENCE

Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS Method

(2011) Annika Öhrfelt et al.   NEUROCHEMICAL RESEARCH

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Cysteine Oxidation in DJ-1 Function and Dysfunction

(2010) Mark A. Wilson   ANTIOXIDANTS & REDOX SIGNALING

Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease

(2010) Min Shi et al.   NEUROSCIENCE LETTERS

Ribosylation Rapidly Induces α-Synuclein to Form Highly Cytotoxic Molten Globules of Advanced Glycation End Products

(2010) Lan Chen et al.   PLoS One

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

(2009) Philipp J. Kahle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidizable Residues Mediating Protein Stability and Cytoprotective Interaction of DJ-1 with Apoptosis Signal-regulating Kinase 1

(2009) Jens Waak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

(2009) Jeff Blackinton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The modification of α-synuclein by dicarbonyl compounds inhibits its fibril-forming process

(2008) Daekyun Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

DJ-1 protects against dopamine toxicity

(2008) Nirit Lev et al.   JOURNAL OF NEURAL TRANSMISSION

Advanced glycation end products induce in vitro cross‐linking of α‐synuclein and accelerate the process of intracellular inclusion body formation

(2008) Shamim Shaikh et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitochondrial localization of DJ-1 leads to enhanced neuroprotection

(2008) Eunsung Junn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70

(2008) Sara Batelli et al.   PLoS One

Structural effects of Parkinson's disease linked DJ-1 mutations

(2008) Gaetano Malgieri et al.   PROTEIN SCIENCE