Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite

The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease

(2021) Pauline Mencke et al.   Cells

The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi

(2021) Benoit Ury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocyte-neuron metabolic cooperation shapes brain activity

(2021) Gilles Bonvento et al.   Cell Metabolism

Reversible histone glycation is associated with disease-related changes in chromatin architecture

(2019) Qingfei Zheng et al.   Nature Communications

Parkinsonism in PGK1 deficiency implicates the glycolytic pathway in nigrostriatal dysfunction

(2019) Hugo Morales-Briceño et al.   PARKINSONISM & RELATED DISORDERS

Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases

(2019) Rong Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis

(2019) Guido T. Bommer et al.   TRENDS IN BIOCHEMICAL SCIENCES

The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals

(2019) Anna Andreeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice

(2019) Olga Burmistrova et al.   Scientific Reports

Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks

(2018) James J. Galligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Reply to Richarme: Evidence against a role of DJ-1 in methylglyoxal detoxification

(2017) Daniel H. Pfaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-enzymatic molecular damage as a prototypic driver of aging

(2017) Alexey Golubev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

(2017) Alice Biosa et al.   NEUROBIOLOGY OF DISEASE

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs

(2017) Gilbert Richarme et al.   SCIENCE

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease

(2017) Francois Mouton-Liger et al.   Frontiers in Molecular Neuroscience

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Parkinson’s disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro

(2017) Noriyuki Matsuda et al.   Scientific Reports

Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes

(2016) Vadim N. Gladyshev   AGING CELL

DJ-1 family Maillard deglycases prevent acrylamide formation

(2016) Gilbert Richarme et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DJ-1 linked parkinsonism (PARK7) is associated with Lewy body pathology

(2016) Ricardo Taipa et al.   BRAIN

A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification

(2016) Jyotiska Chaudhuri et al.   CURRENT BIOLOGY

Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification

(2016) Daniel H. Pfaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Proteomics Approach to the Protein Normalization Problem: Selection of Unvarying Proteins for MS-Based Proteomics and Western Blotting

(2016) Jacek R. Wiśniewski et al.   JOURNAL OF PROTEOME RESEARCH

A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast

(2016) François Collard et al.   Nature Chemical Biology

Early Onset Parkinson's disease due to DJ1 mutations: An Indian study

(2016) Masoom M. Abbas et al.   PARKINSONISM & RELATED DISORDERS

DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulatingpink1

(2015) Raquel Requejo-Aguilar et al.   BIOCHEMICAL JOURNAL

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice

(2015) Sally Yu Shi et al.   Nature Communications

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

(2014) Gilbert Richarme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1

(2014) Raquel Requejo-Aguilar et al.   Nature Communications

Metabolite damage and its repair or pre-emption

(2013) Carole L Linster et al.   Nature Chemical Biology

Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo

(2013) F. Billia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite

(2013) R. E. Moellering et al.   SCIENCE

An Optimized microRNA Backbone for Effective Single-Copy RNAi

(2013) Christof Fellmann et al.   Cell Reports

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration

(2012) P Rodriguez-Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Human DJ-1 and its homologs are novel glyoxalases

(2012) Ju-young Lee et al.   HUMAN MOLECULAR GENETICS

Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease

(2012) M. W. C. Rousseaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

(2009) S. Vasseur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA