DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4

A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3

(2021) Zhefan Stephen Chen et al.   Cell Death & Disease

Parkin ubiquitinates GATA4 and attenuates the GATA4/GAS1 signaling and detrimental effects on diabetic nephropathy

(2020) Kehong Chen et al.   FASEB JOURNAL

Transcription Factor Bhlhe40 in Immunity and Autoimmunity

(2020) Melissa E. Cook et al.   TRENDS IN IMMUNOLOGY

Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4

(2019) Hui Li et al.   CARDIOVASCULAR RESEARCH

Hepatic IRF2BP2 Mitigates Nonalcoholic Fatty Liver Disease by Directly Repressing the Transcription of ATF3

(2019) Jing Fang et al.   HEPATOLOGY

From embryogenesis to adulthood: Critical role for GATA factors in heart development and function

(2019) Jamieson Whitcomb et al.   IUBMB LIFE

Dec1 Deficiency Suppresses Cardiac Perivascular Fibrosis Induced by Transverse Aortic Constriction

(2019) Le et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy

(2019) Lihua Qi et al.   Cell Death & Disease

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Dural effects of oxidative stress on cardiomyogenesis via Gata4 transcription and protein ubiquitination

(2018) Tao Li et al.   Cell Death & Disease

Control of Pathological Cardiac Hypertrophy by Transcriptional Corepressor IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein 2)Novelty and Significance

(2017) Jing Fang et al.   HYPERTENSION

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

(2017) Pi-Xiao Wang et al.   NATURE MEDICINE

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

Cardiac-Specific EPI64C Blunts Pressure Overload–Induced Cardiac HypertrophyNovelty and Significance

(2016) Xuehai Zhu et al.   HYPERTENSION

Regulation of Cardiac Transcription Factor GATA4 by Post-Translational Modification in Cardiomyocyte Hypertrophy and Heart Failure

(2016) Yasufumi Katanasaka et al.   International Heart Journal

Physiological and pathological cardiac hypertrophy

(2016) Ippei Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA-26a protects against cardiac hypertrophy via inhibiting GATA4 in rat model and cultured cardiomyocytes

(2016) Yan Liu et al.   Molecular Medicine Reports

MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy

(2015) Gaurav Mehta et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes

(2015) K Mahajan   ONCOGENE

Splicing and beyond: The many faces of the Prp19 complex

(2013) Sittinan Chanarat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4

(2013) Duk-Hwa Kwon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry

(2013) Alexandre Maréchal et al.   MOLECULAR CELL

PRC2 directly methylates GATA4 and represses its transcriptional activity

(2012) A. He et al.   GENES & DEVELOPMENT

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

(2010) E. J. Song et al.   GENES & DEVELOPMENT

Identification of p300-targeted Acetylated Residues in GATA4 during Hypertrophic Responses in Cardiac Myocytes

(2008) Tomohide Takaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY