Parkin ubiquitinates GATA4 and attenuates the GATA4/GAS1 signaling and detrimental effects on diabetic nephropathy

Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

(2020) Youguang Gao et al.   Journal of Translational Medicine

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Stress-induced phospho-ubiquitin formation causes parkin degradation

(2019) Lyudmila Kovalchuke et al.   Scientific Reports

PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

(2018) Chengyuan Tang et al.   Autophagy

Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

(2018) Kehong Chen et al.   Cell Death & Disease

Optineurin inhibits NLRP3 inflammasome activation by enhancing mitophagy of renal tubular cells in diabetic nephropathy

(2018) Kehong Chen et al.   FASEB JOURNAL

PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury

(2018) Ying Wang et al.   Cell Death & Disease

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

Pink1/Parkin-mediated mitophagy play a protective role in cisplatin induced renal tubular epithelial cells injury

(2017) Chuanyan Zhao et al.   EXPERIMENTAL CELL RESEARCH

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program

(2017) Anna E. Mazzucco et al.   GENES & DEVELOPMENT

Tissue expression of tubular injury markers is associated with renal function decline in diabetic nephropathy

(2017) Subin Hwang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury

(2017) Selim Fakhruddin et al.   Journal of Diabetes Research

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Involvement of Parkin in the ubiquitin proteasome system-mediated degradation of N-type voltage-gated Ca2+ channels

(2017) Lizbeth Grimaldo et al.   PLoS One

Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation

(2016) Y. Marmary et al.   CANCER RESEARCH

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6

(2016) Nunzia D’Onofrio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transcription Factor Trps1 Promotes Tubular Cell Proliferation after Ischemia-Reperfusion Injury through cAMP–Specific 3′,5′-Cyclic Phosphodiesterase 4D and AKT

(2016) Yang Ju-Rong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy

(2015) Jun Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals

(2015) M. Kann et al.   DEVELOPMENT

Death, end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes

(2015) Samy Hadjadj et al.   DIABETOLOGIA

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

(2015) Seung Baek Lee et al.   MOLECULAR CELL

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

GATA get a hold on senescence

(2015) L. D. Cassidy et al.   SCIENCE

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy

(2014) Kento Kitada et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Parkin and mitochondrial quality control: toward assembling the puzzle

(2014) Konstanze F. Winklhofer   TRENDS IN CELL BIOLOGY

The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1

(2014) Richard G. Carroll et al.   Cell Reports

ATP-P2X4 signaling mediates NLRP3 inflammasome activation: A novel pathway of diabetic nephropathy

(2013) Kehong Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Senescence Limits Regenerative Capacity and Allograft Survival

(2012) H. Braun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

TGF- /Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29

(2011) W. Qin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart

(2011) A. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy

(2011) Jun Liu et al.   Translational Research

The role of tubular injury in diabetic nephropathy

(2009) Caroline Jane Magri et al.   European Journal of Internal Medicine