Novel Hybrids of 3-Substituted Coumarin and Phenylsulfonylfuroxan as Potent Antitumor Agents with Collateral Sensitivity against MCF-7/ADR

SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells

(2020) Su-Wei Xu et al.   PHARMACOLOGICAL RESEARCH

Visualizing Nitric oxide in mitochondria and lysosomes of living cells with N-Nitrosation of BODIPY-based fluorescent probes

(2019) Zhiliang Yu et al.   ANALYTICA CHIMICA ACTA

Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids

(2019) Harbinder Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Coumarin-containing hybrids and their anticancer activities

(2019) Longfei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones

(2018) Lina Al-Akra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents

(2018) Yalan Guo et al.   ACS Medicinal Chemistry Letters

Comparative study of the differential cell death protecting effect of various ROS scavengers

(2018) Nežka Kavčič et al.   BIOLOGICAL CHEMISTRY

A novel hybrid of 3-benzyl coumarin seco-B-ring derivative and phenylsulfonylfuroxan induces apoptosis and autophagy in non-small-cell lung cancer

(2018) Mengxue Dong et al.   PHYTOMEDICINE

Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo

(2017) Xiaoke Gu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT)

(2016) Elaine M. Gutierrez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance

(2016) Nicole Seebacher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anticancer efficacy of a nitric oxide-modified derivative of bifendate against multidrug-resistant cancer cells

(2016) Zhiguang Ren et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structure–Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance

(2016) Alexandra E. Stacy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Improvement of Transmembrane Transport Mechanism Study of Imperatorin on P-Glycoprotein-Mediated Drug Transport

(2016) Zheng-Gen Liao et al.   MOLECULES

Crocin suppresses multidrug resistance in MRP overexpressing ovarian cancer cell line

(2016) Shadi Mahdizadeh et al.   DARU-Journal of Pharmaceutical Sciences

Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)

(2015) Patric J. Jansson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter

(2015) Nicole A. Seebacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide Donor

(2015) Wenwen Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A reactive oxygen species activation mechanism contributes to JS-K-induced apoptosis in human bladder cancer cells

(2015) Mingning Qiu et al.   Scientific Reports

The Anticancer Agent Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Prosurvival Autophagy by Two Mechanisms

(2014) Elaine Gutierrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hybrids of Phenylsulfonylfuroxan and Coumarin as Potent Antitumor Agents

(2014) Ming-Ming Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration

(2013) Tetsuo Yamagishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel antileukemic agents derived from tamibarotene and nitric oxide donors

(2011) Haiyong Bian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes

(2011) D. B. Lovejoy et al.   CANCER RESEARCH

Novel Nitric Oxide-Releasing Derivatives of Farnesylthiosalicylic Acid: Synthesis and Evaluation of Antihepatocellular Carcinoma Activity

(2011) Yong Ling et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents

(2010) Yong Ling et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Nitric Oxide-Donating Thalidomide Analogues as Anticancer Agents

(2009) Tao Wang et al.   CHEMISTRY & BIODIVERSITY

Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid

(2009) Zhangjian Huang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The chemical biology of nitric oxide: Implications in cellular signaling

(2008) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Design, Synthesis, and Antihepatocellular Carcinoma Activity of Nitric Oxide Releasing Derivatives of Oleanolic Acid

(2008) Li Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent developments in nitric oxide donor drugs

(2007) M R Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY